1-PYRIMIDIN-2-YL-PIPERIDIN-4-OL
- Product Name
- 1-PYRIMIDIN-2-YL-PIPERIDIN-4-OL
- CAS No.
- 893755-98-1
- Chemical Name
- 1-PYRIMIDIN-2-YL-PIPERIDIN-4-OL
- Synonyms
- 1-(2-Pyrimidinyl)-4-piperidinol;1-PYRIMIDIN-2-YL-PIPERIDIN-4-OL;4-Piperidinol, 1-(2-pyrimidinyl)-;4-Hydroxy-1-(2-pyrimidyl)piperidine;N-(2-Pyrimidinyl)-4-hydroxypiperidine;1,3-Benzodioxole-5-carboxaldehyde,9-methoxy-;1-PYRIMIDIN-2-YL-PIPERIDIN-4-OL ISO 9001：2015 REACH;2-Naphthalenesulfonylchloride,5,6,7,8-tetrahydro-5,5,8,13-tetramethyl-
- CBNumber
- CB2257374
- Molecular Formula
- C9H13N3O
- Formula Weight
- 179.22
- MOL File
- 893755-98-1.mol
1-PYRIMIDIN-2-YL-PIPERIDIN-4-OL Property
- Boiling point:
- 365.5±52.0 °C(Predicted)
- Density
- 1.234±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 14.56±0.20(Predicted)
- Appearance
- White to off-white Solid
- InChI
- InChI=1S/C9H13N3O/c13-8-2-6-12(7-3-8)9-10-4-1-5-11-9/h1,4-5,8,13H,2-3,6-7H2
- InChIKey
- ZATIGSFNFLXZAS-UHFFFAOYSA-N
- SMILES
- N1(C2=NC=CC=N2)CCC(O)CC1
Safety
- HS Code
- 2933599590
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- P997393
- Product name
- 1-(Pyrimidin-2-yl)piperidin-4-ol
- Packaging
- 50mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- COR0001388
- Product name
- 1-PYRIMIDIN-2-YL-PIPERIDIN-4-OL
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $117.6
- Updated
- 2021/12/16
- Product number
- 071775
- Product name
- 1-Pyrimidin-2-yl-piperidin-4-ol
- Purity
- 95+%
- Packaging
- 1g
- Price
- $185
- Updated
- 2021/12/16
- Product number
- W9230
- Product name
- 1-Pyrimidin-2-yl-piperidin-4-ol
- Packaging
- 10g
- Price
- $264
- Updated
- 2021/12/16
- Product number
- 36136
- Product name
- 1-(Pyrimidin-2-yl)piperidin-4-ol
- Purity
- 95+%
- Packaging
- 1g
- Price
- $450
- Updated
- 2021/12/16
1-PYRIMIDIN-2-YL-PIPERIDIN-4-OL Chemical Properties,Usage,Production
Synthesis
5382-16-1
1722-12-9
893755-98-1
Step 1: Synthesis of 1-(2-pyrimidinyl)-4-piperidinol (180) 4-Hydroxypiperidine (1.5 g, 14.7 mmol), 2-chloropyrimidine (1.5 g, 13.4 mmol) and diisopropylethylamine (6 mL, 33.5 mmol) were dissolved in 50 mL of acetonitrile. The reaction mixture was heated and stirred at 80 °C for 18 hours. After completion of the reaction, the mixture was concentrated to dryness under reduced pressure. The crude product was purified by fast column chromatography using a 0-60% ethyl acetate/hexane gradient elution to afford 2.1 g (81% yield) of target compound 180 as a white solid. 1H NMR (400 MHz, CDCl3): δ 8.28 (d, J = 4.6 Hz, 2H), 6.49 (t, J = 4.8 Hz, 1H), 4.49-4.33 (m, 2H), 4.01-3.88 (m, 1H), 3.37-3.21 (m, 2H), 2.02-1.90 (m, 2H), 1.60- 1.45 (m, 2H); LCMS (ESI): m/z 180 [M + H]+.
References
[1] Patent: WO2008/8895, 2008, A1. Location in patent: Page/Page column 155; 156
[2] Journal of Medicinal Chemistry, 2012, vol. 55, # 24, p. 10972 - 10994
1-PYRIMIDIN-2-YL-PIPERIDIN-4-OL Preparation Products And Raw materials
Raw materials
Preparation Products
1-PYRIMIDIN-2-YL-PIPERIDIN-4-OL Suppliers
- Tel
- --
- Fax
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- Country
- United Kingdom
- ProdList
- 6565
- Advantage
- 38
View Lastest Price from 1-PYRIMIDIN-2-YL-PIPERIDIN-4-OL manufacturers
- Product
- 1-PYRIMIDIN-2-YL-PIPERIDIN-4-OL 893755-98-1
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons
- Release date
- 2022-02-16