ChemicalBook > CAS DataBase List > 1-PYRIMIDIN-2-YL-PIPERIDIN-4-OL

1-PYRIMIDIN-2-YL-PIPERIDIN-4-OL

Product Name
1-PYRIMIDIN-2-YL-PIPERIDIN-4-OL
CAS No.
893755-98-1
Chemical Name
1-PYRIMIDIN-2-YL-PIPERIDIN-4-OL
Synonyms
1-(2-Pyrimidinyl)-4-piperidinol;1-PYRIMIDIN-2-YL-PIPERIDIN-4-OL;4-Piperidinol, 1-(2-pyrimidinyl)-;4-Hydroxy-1-(2-pyrimidyl)piperidine;N-(2-Pyrimidinyl)-4-hydroxypiperidine;1,3-Benzodioxole-5-carboxaldehyde,9-methoxy-;1-PYRIMIDIN-2-YL-PIPERIDIN-4-OL ISO 9001：2015 REACH;2-Naphthalenesulfonylchloride,5,6,7,8-tetrahydro-5,5,8,13-tetramethyl-
CBNumber
CB2257374
Molecular Formula
C9H13N3O
Formula Weight
179.22
MOL File
893755-98-1.mol
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1-PYRIMIDIN-2-YL-PIPERIDIN-4-OL Property

Boiling point:
365.5±52.0 °C(Predicted)
Density 
1.234±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
pka
14.56±0.20(Predicted)
Appearance
White to off-white Solid
InChI
InChI=1S/C9H13N3O/c13-8-2-6-12(7-3-8)9-10-4-1-5-11-9/h1,4-5,8,13H,2-3,6-7H2
InChIKey
ZATIGSFNFLXZAS-UHFFFAOYSA-N
SMILES
N1(C2=NC=CC=N2)CCC(O)CC1
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Safety

HS Code 
2933599590
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
P997393
Product name
1-(Pyrimidin-2-yl)piperidin-4-ol
Packaging
50mg
Price
$60
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
COR0001388
Product name
1-PYRIMIDIN-2-YL-PIPERIDIN-4-OL
Purity
95.00%
Packaging
1G
Price
$117.6
Updated
2021/12/16
Matrix Scientific
Product number
071775
Product name
1-Pyrimidin-2-yl-piperidin-4-ol
Purity
95+%
Packaging
1g
Price
$185
Updated
2021/12/16
AK Scientific
Product number
W9230
Product name
1-Pyrimidin-2-yl-piperidin-4-ol
Packaging
10g
Price
$264
Updated
2021/12/16
Matrix Scientific
Product number
071775
Product name
1-Pyrimidin-2-yl-piperidin-4-ol
Purity
95+%
Packaging
5g
Price
$399
Updated
2021/12/16
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1-PYRIMIDIN-2-YL-PIPERIDIN-4-OL Chemical Properties,Usage,Production

Synthesis

5382-16-1

1722-12-9

893755-98-1

Step 1: Synthesis of 1-(2-pyrimidinyl)-4-piperidinol (180) 4-Hydroxypiperidine (1.5 g, 14.7 mmol), 2-chloropyrimidine (1.5 g, 13.4 mmol) and diisopropylethylamine (6 mL, 33.5 mmol) were dissolved in 50 mL of acetonitrile. The reaction mixture was heated and stirred at 80 °C for 18 hours. After completion of the reaction, the mixture was concentrated to dryness under reduced pressure. The crude product was purified by fast column chromatography using a 0-60% ethyl acetate/hexane gradient elution to afford 2.1 g (81% yield) of target compound 180 as a white solid. 1H NMR (400 MHz, CDCl3): δ 8.28 (d, J = 4.6 Hz, 2H), 6.49 (t, J = 4.8 Hz, 1H), 4.49-4.33 (m, 2H), 4.01-3.88 (m, 1H), 3.37-3.21 (m, 2H), 2.02-1.90 (m, 2H), 1.60- 1.45 (m, 2H); LCMS (ESI): m/z 180 [M + H]+.

References

[1] Patent: WO2008/8895, 2008, A1. Location in patent: Page/Page column 155; 156
[2] Journal of Medicinal Chemistry, 2012, vol. 55, # 24, p. 10972 - 10994

1-PYRIMIDIN-2-YL-PIPERIDIN-4-OL Preparation Products And Raw materials

Raw materials

Preparation Products

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1-PYRIMIDIN-2-YL-PIPERIDIN-4-OL Suppliers

China 34 Germany 1 India 1 United Kingdom 1 United States 8 Global 45
Alchem Pharmtech,Inc.
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Matrix Scientific
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View Lastest Price from 1-PYRIMIDIN-2-YL-PIPERIDIN-4-OL manufacturers

Dideu Industries Group Limited
Product
1-PYRIMIDIN-2-YL-PIPERIDIN-4-OL 893755-98-1
Price
US $1.10/g
Min. Order
1g
Purity
99.00%
Supply Ability
100 Tons
Release date
2022-02-16

893755-98-1, 1-PYRIMIDIN-2-YL-PIPERIDIN-4-OLRelated Search:

Tebuconazole

  • 1-PYRIMIDIN-2-YL-PIPERIDIN-4-OL
  • 1-(2-Pyrimidinyl)-4-piperidinol
  • N-(2-Pyrimidinyl)-4-hydroxypiperidine
  • 4-Piperidinol, 1-(2-pyrimidinyl)-
  • 1-PYRIMIDIN-2-YL-PIPERIDIN-4-OL ISO 9001：2015 REACH
  • 1,3-Benzodioxole-5-carboxaldehyde,9-methoxy-
  • 2-Naphthalenesulfonylchloride,5,6,7,8-tetrahydro-5,5,8,13-tetramethyl-
  • 4-Hydroxy-1-(2-pyrimidyl)piperidine
  • 893755-98-1