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CAY10606

Product Name
CAY10606
CAS No.
1159576-98-3
Chemical Name
CAY10606
Synonyms
CAY10606;5-LOX-IN-6;2-[(3-Chlorophenyl)methyl]-5-hydroxy-1H-benz[g]indole-3-carboxylic acid, ethyl ester;1H-Benz[g]indole-3-carboxylic acid, 2-[(3-chlorophenyl)methyl]-5-hydroxy-, ethyl ester
CBNumber
CB22590440
Molecular Formula
C22H18ClNO3
Formula Weight
379.84
MOL File
1159576-98-3.mol
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CAY10606 Property

Melting point:
222 °C(Solv: ethyl acetate (141-78-6); cyclohexane (110-82-7))
Boiling point:
624.2±55.0 °C(Predicted)
Density 
1.355±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMF: 25 mg/ml; DMSO: 25 mg/ml; Ethanol: 20 mg/ml
form 
A crystalline solid
pka
8.86±0.30(Predicted)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
13381
Product name
CAY10606
Purity
≥98%
Packaging
1mg
Price
$62
Updated
2024/03/01
Cayman Chemical
Product number
13381
Product name
CAY10606
Purity
≥98%
Packaging
5mg
Price
$270
Updated
2024/03/01
Cayman Chemical
Product number
13381
Product name
CAY10606
Purity
≥98%
Packaging
10mg
Price
$392
Updated
2021/12/16
TRC
Product number
B405078
Product name
2-[(3-chlorophenyl)methyl]-5-hydroxy-1H-benz[g]indole-3-carboxylicacid,ethylester
Packaging
1mg
Price
$50
Updated
2021/12/16
TRC
Product number
B405078
Product name
2-[(3-chlorophenyl)methyl]-5-hydroxy-1H-benz[g]indole-3-carboxylicacid,ethylester
Packaging
2.5mg
Price
$100
Updated
2021/12/16
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CAY10606 Chemical Properties,Usage,Production

Description

5-Lipoxygenase (5-LO) initiates the synthesis of leukotrienes (LTs) from arachidonic acid, primarily in certain leukocyte populations. CAY10606 is a potent, reversible inhibitor of 5-LO, both in cell-free assays (IC50 = 86 nM) and in intact neutrophils (IC50 = 230 nM).1 It prevents the production of LTs in whole blood, whether 5-LO is activated with the calcium ionophore A23187 (IC50 = 1.6 μM) or formyl peptide (fMLP) following priming with lipopolysaccharide (IC50 = 830 nM). In rats subjected to carrageenan-induced pleurisy, CAY10606 significantly reduces both LT biosynthesis and the inflammatory reaction.1

Uses

5-LOX-IN-6 (compound 11a) is a direct and reversible inhibitor of 5-lipoxygenase (5-LO). 5-LOX-IN-6 inhibits 5-LO activity in human neutrophils and recombinant human 5-LO with IC50 values of 0.23 and 0.086 μM, respectively. 5-LOX-IN-6 prevents leukotriene biosynthesis. 5-LOX-IN-6 can be used for inflammatory and allergic disorders research[1].

in vivo

5-LOX-IN-6 (compound 11a) (4 mg/kg, ip) significantly prevents leukotriene B4 production in pleural exudates of λ-carrageenan (HY-N9470)-treated rats, associated with reduced severity of pleurisy[1].

Animal Model:Male Wistar Han rats (220-230 g, n=10 per group)[1]
Dosage:4 mg/kg
Administration:IP, 30 min before λ-carrageenan administration. Rats were anaesthetized and λ-carrageenan (HY-N9470) was injected into the pleural cavity.
Result:significantly reduced the inflammatory reaction measured as exudate volume (77%), inflammatory cell numbers (40%), and LTB4 levels (49%) in the pleural exudates.

IC 50

5-LO; LTB4

References

1. Karg, E.M., Luderer, S., Pergola, C., et al. Structural optimization and biological evaluation of 2-substituted 5-hydroxyindole-3-carboxylates as potent inhibitors of human 5-lipoxygenase J. Med. Chem. 52,3474-3483(2009).

CAY10606 Preparation Products And Raw materials

Raw materials

Preparation Products

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CAY10606 Suppliers

Canada 1 CHINA 28 United States 3 Global 32
BOC Sciences
Tel
1-631-485-4226; 16314854226
Email
info@bocsci.com
Country
United States
ProdList
12952
Advantage
65
Shanghai Beckham Medical Technology Co., Ltd
Tel
13816613772
Fax
QQ: 12922499
Email
huahero21@sina.com
Country
China
ProdList
2519
Advantage
55
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32467
Advantage
58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
Tel
18818260767
Fax
QQ 3610331285
Email
sales@chemegen.com
Country
China
ProdList
11218
Advantage
58
Energy Chemical
Tel
021-58432009 400-005-6266
Fax
021-58436166
Email
marketing1@energy-chemical.com
Country
China
ProdList
44896
Advantage
58
TargetMol Chemicals Inc.
Tel
4008200310
Email
marketing@tsbiochem.com
Country
China
ProdList
24960
Advantage
58
Shanghai Yiyan Biotechnology Co. , Ltd.
Tel
021-69985186 13611928337
Email
3427709316@qq.com
Country
China
ProdList
7982
Advantage
58
Shanghai Yifei Biotechnology Co. , Ltd.
Tel
021-65675885 18964387627
Email
customer_service@efebio.com
Country
China
ProdList
11972
Advantage
58
Cayman Chemical Company
Tel
800-364-9897
Email
sales@caymanchem.com
Country
China
ProdList
6838
Advantage
58
Santa Cruz Biotechnology Inc
Tel
021-60936350
Email
scbt@scbt.com
Country
China
ProdList
6530
Advantage
58

1159576-98-3, CAY10606Related Search:


  • CAY10606
  • 2-[(3-Chlorophenyl)methyl]-5-hydroxy-1H-benz[g]indole-3-carboxylic acid, ethyl ester
  • 1H-Benz[g]indole-3-carboxylic acid, 2-[(3-chlorophenyl)methyl]-5-hydroxy-, ethyl ester
  • 5-LOX-IN-6
  • 1159576-98-3