JP83

Product Name: JP83
CAS No.: 887264-44-0
Chemical Name: JP83
Synonyms: JP83;JMLPLSJWSHVJLP-UHFFFAOYSA-N;Carbamic acid, N-(6-phenylhexyl)-, 3'-(aminocarbonyl)[1,1'-biphenyl]-3-yl ester
CBNumber: CB22591407
Molecular Formula: C26H28N2O3
Formula Weight: 416.51
MOL File: 887264-44-0.mol

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JP83 Property

storage temp.: Store at -20°C
solubility: ≤1mg/ml in ethanol;30mg/ml in DMSO;30mg/ml in dimethyl formamide
form: crystalline solid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 10008660
Product name: JP83
Purity: ≥98%
Packaging: 5mg
Price: $38
Updated: 2024/03/01

Cayman Chemical

Product number: 10008660
Product name: JP83
Purity: ≥98%
Packaging: 10mg
Price: $71
Updated: 2024/03/01

Cayman Chemical

Product number: 10008660
Product name: JP83
Purity: ≥98%
Packaging: 50mg
Price: $292
Updated: 2024/03/01

ApexBio Technology

Product number: C4983
Product name: JP83
Packaging: 50mg
Price: $333
Updated: 2021/12/16

ApexBio Technology

Product number: C4983
Product name: JP83
Packaging: 10mg
Price: $79
Updated: 2021/12/16

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JP83 Chemical Properties,Usage,Production

Definition

ChEBI: JP83 is a member of biphenyls.

Biological Activity

jp83 is an irreversible fatty acyl amide hydrolase (faah) inhibitor.the enzyme fatty acyl amide hydrolase (faah) is capable of hydrolyzing anandamide and other esters and amides with long unsaturated acyl chains, which is widely expressed in brain and other tissues.

in vitro

jp83 was identified as an irreversible faah inhibitor of the carbamate class when it was tested using radiolabeled oleamide as the substrate. ms results indicated that it inhibited faah by carbamylation of the enzyme’s serine nucleophile. in addition, jp83 was found to be able to inhibit faah with equal or greater potency than urb597 [1].

in vivo

mice were treated with jp104, a close analog of jp83, after which they were sacrificed and their tissues removed for click chemistry analysis. it was found that at 1 mg/kg of jp104, faah labeling was ~80% of maximum in the brain, while none of the liver and kidney targets were modified to greater than 20%. furthermore, the nearly complete inactivation of brain faah by jp104 at 1 mg/kg was confirmed by competitive abpp studies with fp-rh. in contrast, jp104 couldnot reduce the intensity of fp-rh signals in liver and kidney proteomes significantly [1].

IC 50

14 nm for the human recombinant enzyme

References

[1] alexander, j. p., and cravatt, b.f. mechanism of carbmate inactivation of faah: implications for the design of covalent inhibitors and in vivo functional probes for enzymes. chemistry & biology 12, 1179-1187 (2005).

JP83 Preparation Products And Raw materials

Raw materials

Preparation Products

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JP83 Suppliers

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887264-44-0, JP83Related Search:

JP83

JMLPLSJWSHVJLP-UHFFFAOYSA-N

Carbamic acid, N-(6-phenylhexyl)-, 3'-(aminocarbonyl)[1,1'-biphenyl]-3-yl ester

887264-44-0