6-Methyl-3piperidinecarboxylic acid Methyl ester

6-Methyl-3piperidinecarboxylic acid Methyl ester Property

Boiling point:

205.9±33.0 °C(Predicted)

Density 

0.982±0.06 g/cm3(Predicted)

storage temp. 

Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

pka

9.47±0.10(Predicted)

Appearance

Colorless to light yellow Liquid

optical activity

0.40°(C=0.01g/ml CHCL3)

Safety

HS Code 

2933399990

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

6-Methyl-3piperidinecarboxylic acid Methyl ester Chemical Properties,Usage,Production

Synthesis

The general procedure for the synthesis of methyl 6-methyl-3-piperidinecarboxylate from methyl 6-methylnicotinate was as follows: methanol (300 mL), concentrated hydrochloric acid (13.0 g), 10% Pd/C catalyst (4.0 g), and methyl 6-methylnicotinate (20.0 g, 132 mmol) were added to a 400 mL Fisher-Porter reactor. The mixture was heated to 80 °C and stirred at 60 psi hydrogen pressure for 21 hours. Upon completion of the reaction, the mixture was cooled and filtered to remove the catalyst. The filtrate was evaporated under reduced pressure to afford methyl 6-methyl-3-piperidinecarboxylate (27.0 g, quantitative yield). The structure of the product was confirmed by 1H NMR to be consistent with the target compound.

References

[1] Patent: US2010/93706, 2010, A1. Location in patent: Page/Page column 34
[2] Patent: EP3248980, 2017, A1. Location in patent: Paragraph 0163; 0164; 0165
[3] Patent: WO2010/124055, 2010, A1. Location in patent: Page/Page column 39-40
[4] Patent: WO2011/26917, 2011, A1. Location in patent: Page/Page column 93
[5] Patent: WO2011/26904, 2011, A1. Location in patent: Page/Page column 93