1-(3-BroMo-4-fluorophenyl)ethanol
- Product Name
- 1-(3-BroMo-4-fluorophenyl)ethanol
- CAS No.
- 900175-01-1
- Chemical Name
- 1-(3-BroMo-4-fluorophenyl)ethanol
- Synonyms
- 1-(3-Bromo-4-fluorophenyl);1-(3-BroMo-4-fluorophenyl)ethanol;1-(3-bromo-4-fluorophenyl)ethan-1-ol;3-bromo-4-fluoro-2-methylBenzenemethanol;Benzenemethanol, 3-bromo-4-fluoro-α-methyl-
- CBNumber
- CB22594509
- Molecular Formula
- C8H8BrFO
- Formula Weight
- 219.05
- MOL File
- 900175-01-1.mol
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B700940
- Product name
- 1-(3-Bromo-4-fluorophenyl)ethanol
- Packaging
- 500mg
- Price
- $90
- Updated
- 2021/12/16
- Product number
- HCH0069173
- Product name
- 1-(3-BROMO-4-FLUOROPHENYL)ETHANOL
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $199.5
- Updated
- 2021/12/16
- Product number
- 4966AC
- Product name
- 1-(3-Bromo-4-fluorophenyl)ethanol
- Packaging
- 10g
- Price
- $533
- Updated
- 2021/12/16
- Product number
- 4966AC
- Product name
- 1-(3-Bromo-4-fluorophenyl)ethanol
- Packaging
- 25g
- Price
- $1072
- Updated
- 2021/12/16
- Product number
- HCH0069173
- Product name
- 1-(3-BROMO-4-FLUOROPHENYL)ETHANOL
- Purity
- 95.00%
- Packaging
- 5G
- Price
- $1206.98
- Updated
- 2021/12/16
1-(3-BroMo-4-fluorophenyl)ethanol Chemical Properties,Usage,Production
Synthesis
1007-15-4
900175-01-1
General procedure for the synthesis of 1-(3-bromo-4-fluorophenyl)ethanol from 1-(3-bromo-4-fluorophenyl)ethan-1-one: sodium borohydride (2.1 g, 55.5 mmol) was added batchwise to a mixture of 1-(3-bromo-4-fluorophenyl)ethan-1-one (10 g, 46 mmol) in a solution of tetrahydrofuran (THF, 100 mL) and methanol (1.0 mL) . The reaction mixture was heated to 70 °C and maintained for 1 h, followed by cooling to room temperature. Upon completion of the reaction, the reaction was quenched with 1N hydrochloric acid solution (100 mL) and extracted with ethyl acetate (EtOAc, 3 x 100 mL). The organic phases were combined, washed with saturated brine, dried over anhydrous magnesium sulfate (MgSO4) and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography to afford 1-(3-bromo-4-fluorophenyl)ethanol (9.8 g, 97% yield).1H NMR (400 MHz, CDCl3) δppm: 1.48 (d, J=6.15 Hz, 3H), 7.24-7.33 (m, 1H), 7.59 (dd, J=6.59,2.20 Hz, 1H).
References
[1] Patent: WO2006/76246, 2006, A2. Location in patent: Page/Page column 155
[2] Patent: US2007/3539, 2007, A1. Location in patent: Page/Page column 80
[3] Tetrahedron Letters, 2007, vol. 48, # 31, p. 5471 - 5474
[4] European Journal of Organic Chemistry, 2011, # 23, p. 4409 - 4414
[5] Patent: WO2018/81047, 2018, A1. Location in patent: Page/Page column 185
1-(3-BroMo-4-fluorophenyl)ethanol Preparation Products And Raw materials
Raw materials
Preparation Products
1-(3-BroMo-4-fluorophenyl)ethanol Suppliers
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