Methyl 5-Benzyloxy-4-Methoxy-2-nitrobenzoate
- Product Name
- Methyl 5-Benzyloxy-4-Methoxy-2-nitrobenzoate
- CAS No.
- 164161-49-3
- Chemical Name
- Methyl 5-Benzyloxy-4-Methoxy-2-nitrobenzoate
- Synonyms
- Methyl 5-Benzyloxy-4-Methoxy-2-nitrobenzoate;Methyl 4-methoxy-2-nitro-5-(phenylmethoxy)benzoate;Benzoicacid,4-Methoxy-2-nitro-5-(phenylMethoxy)-,Methylester
- CBNumber
- CB22597368
- Molecular Formula
- C16H15NO6
- Formula Weight
- 317.29
- MOL File
- 164161-49-3.mol
Methyl 5-Benzyloxy-4-Methoxy-2-nitrobenzoate Property
- Boiling point:
- 482.4±40.0 °C(Predicted)
- Density
- 1.280
- storage temp.
- Sealed in dry,Room Temperature
- Appearance
- White to off-white Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- W3579
- Product name
- Methyl5-Benzyloxy-4-methoxy-2-nitrobenzoate
- Packaging
- 250mg
- Price
- $108
- Updated
- 2021/12/16
- Product number
- W3579
- Product name
- Methyl5-Benzyloxy-4-methoxy-2-nitrobenzoate
- Packaging
- 5g
- Price
- $429
- Updated
- 2021/12/16
- Product number
- 074744
- Product name
- Methyl 5-benzyloxy-4-methoxy-2-nitrobenzoate
- Purity
- 95+%
- Packaging
- 1g
- Price
- $462
- Updated
- 2021/12/16
- Product number
- W3579
- Product name
- Methyl5-Benzyloxy-4-methoxy-2-nitrobenzoate
- Packaging
- 10g
- Price
- $616
- Updated
- 2021/12/16
- Product number
- CHM0167693
- Product name
- METHYL-5-BENZYLOXY-4-METHOXY-2-NITROBENZOATE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $1085.7
- Updated
- 2021/12/16
Methyl 5-Benzyloxy-4-Methoxy-2-nitrobenzoate Chemical Properties,Usage,Production
Synthesis
215659-03-3
100-39-0
164161-49-3
The reaction was carried out with methyl 5-hydroxy-4-methoxy-2-nitrobenzoate (15.4 g, 68 mmol) and benzyl bromide (9.7 mL, 82 mmol) in the presence of cesium carbonate (44 g, 136 mmol) with stirring at room temperature in DMSO (200 mL) for 24 hours. After completion of the reaction, the reaction mixture was diluted with ethyl acetate (~2 L) and n-butanol (~100 mL). The organic layer was washed sequentially with water and brine, dried with magnesium sulfate, filtered and concentrated. The residue was purified by silica gel column chromatography (eluent ratio from 1:5 to 2:1 ethyl acetate-hexane) to afford methyl 2-nitro-4-methoxy-5-benzyloxybenzoate 20.2 g in 94% yield; MS (AP/CI): 286.1 (M + H)+.
References
[1] Patent: WO2008/20302, 2008, A2. Location in patent: Page/Page column 28
[2] Journal of Medicinal Chemistry, 2011, vol. 54, # 13, p. 4536 - 4547
Methyl 5-Benzyloxy-4-Methoxy-2-nitrobenzoate Preparation Products And Raw materials
Raw materials
Preparation Products
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