4-broMo-2-(1,1,1-trifluoro-2-Methylpropan-2-yl)pyridine
- Product Name
- 4-broMo-2-(1,1,1-trifluoro-2-Methylpropan-2-yl)pyridine
- CAS No.
- 1357476-67-5
- Chemical Name
- 4-broMo-2-(1,1,1-trifluoro-2-Methylpropan-2-yl)pyridine
- Synonyms
- 100346;4-broMo-2-(1,1,1-trifluoro-2-Methylpropan-2-yl);4-Bromo-2-(2,2,2-trifluoro-1,1-dimethylethyl)pyridine;4-broMo-2-(1,1,1-trifluoro-2-Methylpropan-2-yl)pyridine;Pyridine, 4-bromo-2-(2,2,2-trifluoro-1,1-dimethylethyl)-
- CBNumber
- CB22598749
- Molecular Formula
- C9H9BrF3N
- Formula Weight
- 268.07
- MOL File
- 1357476-67-5.mol
4-broMo-2-(1,1,1-trifluoro-2-Methylpropan-2-yl)pyridine Property
- Boiling point:
- 209.3±40.0 °C(Predicted)
- Density
- 1.473±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 2.29±0.10(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B421233
- Product name
- 4-Bromo-2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridine
- Packaging
- 10mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- B421233
- Product name
- 4-Bromo-2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridine
- Packaging
- 50mg
- Price
- $220
- Updated
- 2021/12/16
- Product number
- 120592
- Product name
- 4-Bromo-2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridine
- Purity
- 97%
- Packaging
- 250mg
- Price
- $1072
- Updated
- 2021/12/16
- Product number
- 120592
- Product name
- 4-Bromo-2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridine
- Purity
- 97%
- Packaging
- 1g
- Price
- $3232
- Updated
- 2021/12/16
- Product number
- CM173026
- Product name
- 4-Bromo-2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridine
- Purity
- 95%
- Packaging
- 1g
- Price
- $716
- Updated
- 2021/12/16
4-broMo-2-(1,1,1-trifluoro-2-Methylpropan-2-yl)pyridine Chemical Properties,Usage,Production
Synthesis
To a solution of 18-6 (8.7 g, 42.40 mmol, 1 eq) in 1,2-dichloroethane (90 mL) was added Phosphorus(V) oxybromide (18.23 g, 63.60 mmol, 6.47 mL, 1.5 eq). The mixture was stirred at 80°C for 4 hours. TLC (Petroleum ether: Ethyl acetate: Ethanol =4:3:1) showed a part of starting material was remained. Another Phosphorus (V) oxybromide (6.08 g, 21.20 mmol, 2.16 mL, 0.5 eq) was added into the mixture. The reaction mixture was stirred at 80°C for another 3 hours. TLC (Petroleum ether: ethyl acetate: ethanol=4:3:1) showed the starting material was consumed completely. The mixture was combined with another batch (1 g scale) and then poured into ice saturated sodium bicarbonate solution (300 mL) and adjust the pH=7~8. The mixture was extracted with ethyl acetate (100 mLx3). The combined organic layers were washed with brine (100 mL), dried over anhydrous sodium sulfate, filtered, concentrated in vacuum. The residue was purified by column chromatography (SiO2, Petroleum ether: ethyl acetate=1:0 to 50:11) to give 18-7 (8.5 g, 31.71 mmol, 67.37% yield, 100% purity) as light yellow oil.
Synthesis
4-broMo-2-(1,1,1-trifluoro-2-Methylpropan-2-yl)pyridine can be used as organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory research and development process and chemical production process.
4-broMo-2-(1,1,1-trifluoro-2-Methylpropan-2-yl)pyridine Preparation Products And Raw materials
Raw materials
Preparation Products
4-broMo-2-(1,1,1-trifluoro-2-Methylpropan-2-yl)pyridine Suppliers
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- Product
- 4-broMo-2-(1,1,1-trifluoro-2-Methylpropan-2-yl)pyridine 1357476-67-5
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-09-27