ChemicalBook > CAS DataBase List > (R)-N-(2-(3-((3-hydroxypyrrolidin-1-yl)Methyl)iMidazo[2,1-b]thiazol-6-yl)phenyl)-2-naphthaMide

(R)-N-(2-(3-((3-hydroxypyrrolidin-1-yl)Methyl)iMidazo[2,1-b]thiazol-6-yl)phenyl)-2-naphthaMide

Product Name
(R)-N-(2-(3-((3-hydroxypyrrolidin-1-yl)Methyl)iMidazo[2,1-b]thiazol-6-yl)phenyl)-2-naphthaMide
CAS No.
1001908-89-9
Chemical Name
(R)-N-(2-(3-((3-hydroxypyrrolidin-1-yl)Methyl)iMidazo[2,1-b]thiazol-6-yl)phenyl)-2-naphthaMide
Synonyms
SRT2183;Inhibitor,Sirtuin,Apoptosis,SRT-2183,SRT 2183,inhibit,SRT2183;(R)-N-(2-(3-((3-hydroxypyrrolidin-1-yl)Methyl)iMidazo[2,1-b]thiazol-6-yl)phenyl)-2-naphthaMide;2-Naphthalenecarboxamide, N-[2-[3-[[(3R)-3-hydroxy-1-pyrrolidinyl]methyl]imidazo[2,1-b]thiazol-6-yl]phenyl]-
CBNumber
CB22599993
Molecular Formula
C27H24N4O2S
Formula Weight
468.57
MOL File
1001908-89-9.mol
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(R)-N-(2-(3-((3-hydroxypyrrolidin-1-yl)Methyl)iMidazo[2,1-b]thiazol-6-yl)phenyl)-2-naphthaMide Property

storage temp. 
Store at -20°C
solubility 
DMSO : 250 mg/mL (533.54 mM; Need ultrasonic)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0016574
Product name
SRT2183
Purity
98.48%
Packaging
5mg
Price
$135
Updated
2021/12/16
ChemScene
Product number
CS-0016574
Product name
SRT2183
Purity
98.48%
Packaging
10mg
Price
$450
Updated
2021/12/16
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(R)-N-(2-(3-((3-hydroxypyrrolidin-1-yl)Methyl)iMidazo[2,1-b]thiazol-6-yl)phenyl)-2-naphthaMide Chemical Properties,Usage,Production

Biological Activity

SRT2183 is a small molecule activator of the sirtuin protein isoform SIRT1.

in vitro

1-20 μM SRT2183 can effectively inhibit cell growth and apoptosis. It can cause increased mRNA levels of genes involved in pro-apoptosis, growth arrest, and DNA damage response. SRT1720, SRT2183, SRT1460 and resveratrol have multiple off-target effects on some receptors, enzymes, transporters and ion channels. They are not direct activators of SIRT1.

target

TargetValue
SIRT1

(R)-N-(2-(3-((3-hydroxypyrrolidin-1-yl)Methyl)iMidazo[2,1-b]thiazol-6-yl)phenyl)-2-naphthaMide Preparation Products And Raw materials

Raw materials

Preparation Products

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(R)-N-(2-(3-((3-hydroxypyrrolidin-1-yl)Methyl)iMidazo[2,1-b]thiazol-6-yl)phenyl)-2-naphthaMide Suppliers

China 27 United States 4 Global 31
Dalian Meilun Biotech Co., Ltd.
Tel
0411-62910999 13889544652
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sales@meilune.com
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China
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4659
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58
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696，15000506266 15000506266
Fax
+86-21-52996696
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China
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4153
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Beijing Solarbio Science & Tecnology Co., Ltd.
Tel
010-50973130 4009686088
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3193328036@qq.com
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China
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29797
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Beijing Jin Ming Biotechnology Co., Ltd.
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010-60605840 18892239720
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010-60605840
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psaitong@jm-bio.com
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China
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12308
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Medi-tech Bioscientific Co., Ltd.
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0519-83246372 13585352506
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0519-83246372
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China
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1844
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Dezhou LonWel Pharmaceutical Technology Co., Ltd.
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13761310616
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QQ: 39324283
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39324283@qq.com
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China
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1953
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Angel Pharmatech, Ltd.
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17317130613
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QQ3358272972
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3358272972@qq.com
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China
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3244
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Fan De(Beijing) Biotechnology Co., Ltd.
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15911056312
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liming@bio-fount.com
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China
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9730
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Guangzhou Tomums Life Science Co., Ltd.
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020-31155029 18902330969
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020-31155029
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sales@tomums.cn
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China
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TargetMol Chemicals Inc.
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+1-781-999-5354 +1-00000000000
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marketing@targetmol.com
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United States
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19892
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1001908-89-9, (R)-N-(2-(3-((3-hydroxypyrrolidin-1-yl)Methyl)iMidazo[2,1-b]thiazol-6-yl)phenyl)-2-naphthaMideRelated Search:


  • (R)-N-(2-(3-((3-hydroxypyrrolidin-1-yl)Methyl)iMidazo[2,1-b]thiazol-6-yl)phenyl)-2-naphthaMide
  • SRT2183
  • 2-Naphthalenecarboxamide, N-[2-[3-[[(3R)-3-hydroxy-1-pyrrolidinyl]methyl]imidazo[2,1-b]thiazol-6-yl]phenyl]-
  • Inhibitor,Sirtuin,Apoptosis,SRT-2183,SRT 2183,inhibit,SRT2183
  • 1001908-89-9