ChemicalBook > CAS DataBase List > (R)-N-(2-(3-((3-hydroxypyrrolidin-1-yl)Methyl)iMidazo[2,1-b]thiazol-6-yl)phenyl)-2-naphthaMide
(R)-N-(2-(3-((3-hydroxypyrrolidin-1-yl)Methyl)iMidazo[2,1-b]thiazol-6-yl)phenyl)-2-naphthaMide
- Product Name
- (R)-N-(2-(3-((3-hydroxypyrrolidin-1-yl)Methyl)iMidazo[2,1-b]thiazol-6-yl)phenyl)-2-naphthaMide
- CAS No.
- 1001908-89-9
- Chemical Name
- (R)-N-(2-(3-((3-hydroxypyrrolidin-1-yl)Methyl)iMidazo[2,1-b]thiazol-6-yl)phenyl)-2-naphthaMide
- Synonyms
- SRT2183;Inhibitor,Sirtuin,Apoptosis,SRT-2183,SRT 2183,inhibit,SRT2183;(R)-N-(2-(3-((3-hydroxypyrrolidin-1-yl)Methyl)iMidazo[2,1-b]thiazol-6-yl)phenyl)-2-naphthaMide;2-Naphthalenecarboxamide, N-[2-[3-[[(3R)-3-hydroxy-1-pyrrolidinyl]methyl]imidazo[2,1-b]thiazol-6-yl]phenyl]-;N-(2-(3-{[(3R)-3-hydroxypyrrolidin-1-yl]methyl}imidazo[2,1-b][1,3]thiazol-6-yl)phenyl)naphthalene-2-carboxamide
- CBNumber
- CB22599993
- Molecular Formula
- C27H24N4O2S
- Formula Weight
- 468.57
- MOL File
- 1001908-89-9.mol
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(R)-N-(2-(3-((3-hydroxypyrrolidin-1-yl)Methyl)iMidazo[2,1-b]thiazol-6-yl)phenyl)-2-naphthaMide Property
- storage temp.
- Store at -20°C
- solubility
- DMSO : 250 mg/mL (533.54 mM; Need ultrasonic)
- form
- Solid
- color
- Light yellow to yellow
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N-Bromosuccinimide Price
ChemScene
- Product number
- CS-0016574
- Product name
- SRT2183
- Purity
- 98.48%
- Packaging
- 5mg
- Price
- $135
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-0016574
- Product name
- SRT2183
- Purity
- 98.48%
- Packaging
- 10mg
- Price
- $450
- Updated
- 2021/12/16
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(R)-N-(2-(3-((3-hydroxypyrrolidin-1-yl)Methyl)iMidazo[2,1-b]thiazol-6-yl)phenyl)-2-naphthaMide Chemical Properties,Usage,Production
Biological Activity
SRT2183 is a small molecule activator of the sirtuin protein isoform SIRT1.
in vitro
1-20 μM SRT2183 can effectively inhibit cell growth and apoptosis. It can cause increased mRNA levels of genes involved in pro-apoptosis, growth arrest, and DNA damage response. SRT1720, SRT2183, SRT1460 and resveratrol have multiple off-target effects on some receptors, enzymes, transporters and ion channels. They are not direct activators of SIRT1.
target
Target | Value |
SIRT1 |
(R)-N-(2-(3-((3-hydroxypyrrolidin-1-yl)Methyl)iMidazo[2,1-b]thiazol-6-yl)phenyl)-2-naphthaMide Preparation Products And Raw materials
Raw materials
Preparation Products
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(R)-N-(2-(3-((3-hydroxypyrrolidin-1-yl)Methyl)iMidazo[2,1-b]thiazol-6-yl)phenyl)-2-naphthaMide Suppliers
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