ChemicalBook > CAS DataBase List > (R)-N-(2-(3-((3-hydroxypyrrolidin-1-yl)Methyl)iMidazo[2,1-b]thiazol-6-yl)phenyl)-2-naphthaMide

(R)-N-(2-(3-((3-hydroxypyrrolidin-1-yl)Methyl)iMidazo[2,1-b]thiazol-6-yl)phenyl)-2-naphthaMide

Product Name
(R)-N-(2-(3-((3-hydroxypyrrolidin-1-yl)Methyl)iMidazo[2,1-b]thiazol-6-yl)phenyl)-2-naphthaMide
CAS No.
1001908-89-9
Chemical Name
(R)-N-(2-(3-((3-hydroxypyrrolidin-1-yl)Methyl)iMidazo[2,1-b]thiazol-6-yl)phenyl)-2-naphthaMide
Synonyms
SRT2183;Inhibitor,Sirtuin,Apoptosis,SRT-2183,SRT 2183,inhibit,SRT2183;(R)-N-(2-(3-((3-hydroxypyrrolidin-1-yl)Methyl)iMidazo[2,1-b]thiazol-6-yl)phenyl)-2-naphthaMide;2-Naphthalenecarboxamide, N-[2-[3-[[(3R)-3-hydroxy-1-pyrrolidinyl]methyl]imidazo[2,1-b]thiazol-6-yl]phenyl]-
CBNumber
CB22599993
Molecular Formula
C27H24N4O2S
Formula Weight
468.57
MOL File
1001908-89-9.mol
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(R)-N-(2-(3-((3-hydroxypyrrolidin-1-yl)Methyl)iMidazo[2,1-b]thiazol-6-yl)phenyl)-2-naphthaMide Property

storage temp. 
Store at -20°C
solubility 
DMSO : 250 mg/mL (533.54 mM; Need ultrasonic)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0016574
Product name
SRT2183
Purity
98.48%
Packaging
5mg
Price
$135
Updated
2021/12/16
ChemScene
Product number
CS-0016574
Product name
SRT2183
Purity
98.48%
Packaging
10mg
Price
$450
Updated
2021/12/16
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(R)-N-(2-(3-((3-hydroxypyrrolidin-1-yl)Methyl)iMidazo[2,1-b]thiazol-6-yl)phenyl)-2-naphthaMide Chemical Properties,Usage,Production

Biological Activity

SRT2183 is a small molecule activator of the sirtuin protein isoform SIRT1.

in vitro

1-20 μM SRT2183 can effectively inhibit cell growth and apoptosis. It can cause increased mRNA levels of genes involved in pro-apoptosis, growth arrest, and DNA damage response. SRT1720, SRT2183, SRT1460 and resveratrol have multiple off-target effects on some receptors, enzymes, transporters and ion channels. They are not direct activators of SIRT1.

target

TargetValue
SIRT1

(R)-N-(2-(3-((3-hydroxypyrrolidin-1-yl)Methyl)iMidazo[2,1-b]thiazol-6-yl)phenyl)-2-naphthaMide Preparation Products And Raw materials

Raw materials

Preparation Products

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(R)-N-(2-(3-((3-hydroxypyrrolidin-1-yl)Methyl)iMidazo[2,1-b]thiazol-6-yl)phenyl)-2-naphthaMide Suppliers

China 27 United States 4 Global 31
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
19892
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58
InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
ProdList
6393
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Aladdin Scientific
Tel
+1-+1(833)-552-7181
Email
sales@aladdinsci.com
Country
United States
ProdList
57511
Advantage
58

1001908-89-9, (R)-N-(2-(3-((3-hydroxypyrrolidin-1-yl)Methyl)iMidazo[2,1-b]thiazol-6-yl)phenyl)-2-naphthaMideRelated Search:


  • (R)-N-(2-(3-((3-hydroxypyrrolidin-1-yl)Methyl)iMidazo[2,1-b]thiazol-6-yl)phenyl)-2-naphthaMide
  • SRT2183
  • 2-Naphthalenecarboxamide, N-[2-[3-[[(3R)-3-hydroxy-1-pyrrolidinyl]methyl]imidazo[2,1-b]thiazol-6-yl]phenyl]-
  • Inhibitor,Sirtuin,Apoptosis,SRT-2183,SRT 2183,inhibit,SRT2183
  • 1001908-89-9