ethyl 5-fluoro-3-iodo-1H-indole-2-carboxylate
- Product Name
- ethyl 5-fluoro-3-iodo-1H-indole-2-carboxylate
- CAS No.
- 167631-21-2
- Chemical Name
- ethyl 5-fluoro-3-iodo-1H-indole-2-carboxylate
- Synonyms
- 5-fluoro-3-iodo-1H-indole;ethyl 5-fluoro-3-iodo-1H-indole-2-carboxylate;5-Fluoro-3-iodo-1H-indole-2-carboxylic acid ethyl ester;1H-Indole-2-carboxylic acid, 5-fluoro-3-iodo-, ethyl ester
- CBNumber
- CB22603236
- Molecular Formula
- C11H9FINO2
- Formula Weight
- 333.1
- MOL File
- 167631-21-2.mol
ethyl 5-fluoro-3-iodo-1H-indole-2-carboxylate Property
- Density
- 1.824
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- W3641
- Product name
- Ethyl5-fluoro-3-iodo-1H-indole-2-carboxylate
- Packaging
- 1g
- Price
- $250
- Updated
- 2021/12/16
- Product number
- HCH0368968
- Product name
- ETHYL-5-FLUORO-3-IODO-1H-INDOLE-2-CARBOXYLATE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $499.57
- Updated
- 2021/12/16
- Product number
- W3641
- Product name
- Ethyl5-fluoro-3-iodo-1H-indole-2-carboxylate
- Packaging
- 250mg
- Price
- $134
- Updated
- 2021/12/16
- Product number
- CM148514
- Product name
- Ethyl5-fluoro-3-iodo-1H-indole-2-carboxylate
- Purity
- 95%+
- Packaging
- 1g
- Price
- $184
- Updated
- 2021/12/16
- Product number
- 167631212
- Product name
- Ethyl5-fluoro-3-iodo-1H-indole-2-carboxylate
- Packaging
- 1g
- Price
- $190.8
- Updated
- 2021/12/16
ethyl 5-fluoro-3-iodo-1H-indole-2-carboxylate Chemical Properties,Usage,Production
Synthesis
348-36-7
167631-21-2
Method A: Ethyl 5-fluoroindole-2-carboxylate (1.0 eq.) was mixed with a DMF solution (5 mL) of KOH (4.0 eq.) at room temperature and stirred until a homogeneous suspension was formed. Subsequently, DMF solution (3 mL) of iodine (1.0 eq.) was added slowly and dropwise. The reaction mixture was stirred at room temperature for 1.5 hours. Upon completion of the reaction, the mixture was poured into a mixture consisting of saturated aqueous NaHSO3 solution (15 mL), 30% NH4OH (2 mL) and water (15 mL). The resulting solid product was collected by filtration and dried under reduced pressure, and the resulting ethyl 5-fluoro-3-iodo-1H-indole-2-carboxylate was used for subsequent reactions without further purification.
References
[1] European Journal of Medicinal Chemistry, 2012, vol. 49, p. 379 - 396
[2] European Journal of Organic Chemistry, 2018, vol. 2018, # 45, p. 6314 - 6327
[3] Journal of Medicinal Chemistry, 2008, vol. 51, # 12, p. 3414 - 3421
[4] European Journal of Organic Chemistry, 2008, # 30, p. 5162 - 5175
ethyl 5-fluoro-3-iodo-1H-indole-2-carboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
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