2-Chloro-6-fluorobenzo[d]oxazole
- Product Name
- 2-Chloro-6-fluorobenzo[d]oxazole
- CAS No.
- 153403-53-3
- Chemical Name
- 2-Chloro-6-fluorobenzo[d]oxazole
- Synonyms
- 2-Chloro-6-fluorobenzoxazole;2-Chloro-6-fluoro-benzooxazole;Benzoxazole, 2-chloro-6-fluoro-;2-Chloro-6-fluorobenzo[d]oxazole;2-Chloro-6-fluoro-1,3-benzoxazole
- CBNumber
- CB22603630
- Molecular Formula
- C7H3ClFNO
- Formula Weight
- 171.56
- MOL File
- 153403-53-3.mol
2-Chloro-6-fluorobenzo[d]oxazole Property
- Boiling point:
- 206.9±13.0 °C(Predicted)
- Density
- 1.482±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Store in freezer, under -20°C
- pka
- -0.83±0.30(Predicted)
- form
- fused solid
- color
- Dark brown
Safety
- HS Code
- 2934999090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- C584898
- Product name
- 2-Chloro-6-fluorobenzo[d]oxazole
- Packaging
- 25mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- C584898
- Product name
- 2-Chloro-6-fluorobenzo[d]oxazole
- Packaging
- 50mg
- Price
- $95
- Updated
- 2021/12/16
- Product number
- C584898
- Product name
- 2-Chloro-6-fluorobenzo[d]oxazole
- Packaging
- 100mg
- Price
- $145
- Updated
- 2021/12/16
- Product number
- C584898
- Product name
- 2-Chloro-6-fluorobenzo[d]oxazole
- Packaging
- 250mg
- Price
- $250
- Updated
- 2021/12/16
- Product number
- FC41943
- Product name
- 2-Chloro-6-fluorobenzo[d]oxazole
- Packaging
- 25mg
- Price
- $62.5
- Updated
- 2021/12/16
2-Chloro-6-fluorobenzo[d]oxazole Chemical Properties,Usage,Production
Synthesis
145096-57-7
153403-53-3
The general procedure for the synthesis of 2-chloro-6-fluorobenzoxazole from 6-fluorobenzo[d]oxazole-2(3H)-thione was as follows: to a 500 mL round-bottomed flask was added 6-fluoro-2,3-dihydro-1,3-benzoxazole-2-thione (9.2 g, 54.38 mmol, 1.00 equiv.), thionyl chloride (200 mL) and N,N-dimethylformamide ( DMF, 0.5 mL). The reaction mixture was stirred in an oil bath at 80 °C for 6 hours. Upon completion of the reaction, the excess thionyl chloride was removed by distillation under reduced pressure. The residue was purified by silica gel column chromatography with ethyl acetate/petroleum ether (0/100 to 7/93) as eluent. The fraction containing the target product was collected and concentrated under reduced pressure to give 3.5 g (38% yield) of 2-chloro-6-fluorobenzoxazole as a brown oil. The product was confirmed by LC-MS (electrospray ionization, m/z) with a molecular ion peak [M+H]+ of 172.
References
[1] Patent: WO2014/164749, 2014, A1. Location in patent: Page/Page column 257
2-Chloro-6-fluorobenzo[d]oxazole Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-Chloro-6-fluorobenzo[d]oxazole manufacturers
- Product
- 2-Chloro-6-fluorobenzo[d]oxazole 153403-53-3
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99.5%
- Supply Ability
- 100 tons
- Release date
- 2022-02-08
- Product
- 2-Chloro-6-fluorobenzo[d]oxazole 153403-53-3
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 200kg
- Release date
- 2019-12-20