ethyl 4-broMo-6-Methoxy-1,5-naphthyridine-3-carboxylate

Product Name: ethyl 4-broMo-6-Methoxy-1,5-naphthyridine-3-carboxylate
CAS No.: 724788-64-1
Chemical Name: ethyl 4-broMo-6-Methoxy-1,5-naphthyridine-3-carboxylate
Synonyms: ethyl 4-broMo-6-Methoxy-1,5-naphthyridine-3-carboxylate;4-BroMo-6-Methoxy-[1,5]naphthyridine-3-carboxylic acid ethyl ester;1,5-Naphthyridine-3-carboxylic acid, 4-bromo-6-methoxy-, ethyl ester
CBNumber: CB22604819
Molecular Formula: C12H11BrN2O3
Formula Weight: 311.13
MOL File: 724788-64-1.mol

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ethyl 4-broMo-6-Methoxy-1,5-naphthyridine-3-carboxylate Property

Boiling point:: 381.5±37.0 °C(Predicted)
Density: 1.520±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: 0.23±0.10(Predicted)
Appearance: White to off-white Solid

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

AK Scientific

Product number: 1236AC
Product name: Ethyl4-bromo-6-methoxy-1,5-naphthyridine-3-carboxylate
Packaging: 100mg
Price: $196
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0368871
Product name: ETHYL-4-BROMO-6-METHOXY-1,5-NAPHTHYRIDINE-3-CARBOXYLATE
Purity: 95.00%
Packaging: 5MG
Price: $496.89
Updated: 2021/12/16

AK Scientific

Product number: 1236AC
Product name: Ethyl4-bromo-6-methoxy-1,5-naphthyridine-3-carboxylate
Packaging: 5g
Price: $2121
Updated: 2021/12/16

Ambeed

Product number: A167631
Product name: Ethyl4-bromo-6-methoxy-1,5-naphthyridine-3-carboxylate
Purity: 98%
Packaging: 100mg
Price: $127
Updated: 2021/12/16

Ambeed

Product number: A167631
Product name: Ethyl4-bromo-6-methoxy-1,5-naphthyridine-3-carboxylate
Purity: 98%
Packaging: 250mg
Price: $181
Updated: 2021/12/16

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ethyl 4-broMo-6-Methoxy-1,5-naphthyridine-3-carboxylate Chemical Properties,Usage,Production

Synthesis

724788-63-0

724788-64-1

The general procedure for the synthesis of ethyl 4-bromo-6-methoxy-1,5-naphthyridine-3-carboxylate from ethyl 6-methoxy-4-oxo-1,4-dihydro-1,5-naphthyridine-3-carboxylate was as follows: ethyl 6-methoxy-4-oxo-1,4-dihydro-1,5-naphthyridine-3-carboxylate (6.3 g, 25.4 mmol) was suspended under nitrogen protection in N,N- dimethylformamide (DMF, 20 mL) with stirring at room temperature. Phosphorus tribromide (2.5 mL, 26.7 mmol) was slowly added dropwise and the reaction mixture continued to be stirred for 30 minutes. Upon completion of the reaction, the mixture was cooled in an ice bath and water (120 mL) was slowly added, followed by addition of saturated aqueous sodium bicarbonate to adjust the pH to 7. The precipitate was collected by vacuum filtration, washed with water and dried under vacuum. The crude product was purified by silica gel column chromatography (eluent tapered from cyclohexane 100% to cyclohexane/ethyl acetate 95/5) to afford ethyl 4-bromo-6-methoxy-1,5-naphthyridine-3-carboxylate (6.6 g, 21 mmol, 83% yield).LC-MS analysis showed the molecular ion peak (M-H+) of the target compound was 311.

References

[1] Patent: WO2006/81178, 2006, A2. Location in patent: Page/Page column 18
[2] Patent: WO2006/81264, 2006, A1. Location in patent: Page/Page column 21-22
[3] Patent: WO2006/81289, 2006, A2. Location in patent: Page/Page column 15
[4] Patent: WO2006/81179, 2006, A1. Location in patent: Page/Page column 19
[5] Patent: WO2006/81182, 2006, A2. Location in patent: Page/Page column 19

ethyl 4-broMo-6-Methoxy-1,5-naphthyridine-3-carboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

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ethyl 4-broMo-6-Methoxy-1,5-naphthyridine-3-carboxylate Suppliers

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724788-64-1, ethyl 4-broMo-6-Methoxy-1,5-naphthyridine-3-carboxylateRelated Search:

ethyl 4-broMo-6-Methoxy-1,5-naphthyridine-3-carboxylate

4-BroMo-6-Methoxy-[1,5]naphthyridine-3-carboxylic acid ethyl ester

1,5-Naphthyridine-3-carboxylic acid, 4-bromo-6-methoxy-, ethyl ester

724788-64-1