ChemicalBook > CAS DataBase List > (4-aMino-6-chloropyridin-3-yl)Methanol
(4-aMino-6-chloropyridin-3-yl)Methanol
- Product Name
- (4-aMino-6-chloropyridin-3-yl)Methanol
- CAS No.
- 846036-96-2
- Chemical Name
- (4-aMino-6-chloropyridin-3-yl)Methanol
- Synonyms
- 4-amino-6-chloro-3-Pyridinemethanol;3-Pyridinemethanol, 4-amino-6-chloro-;(4-aMino-6-chloropyridin-3-yl)Methanol
- CBNumber
- CB22604925
- Molecular Formula
- C6H7ClN2O
- Formula Weight
- 158.59
- MOL File
- 846036-96-2.mol
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(4-aMino-6-chloropyridin-3-yl)Methanol Property
- Boiling point:
- 399.8±37.0 °C(Predicted)
- Density
- 1.432±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- pka
- 13.18±0.10(Predicted)
- Appearance
- White to off-white Solid
- InChI
- InChI=1S/C6H7ClN2O/c7-6-1-5(8)4(3-10)2-9-6/h1-2,10H,3H2,(H2,8,9)
- InChIKey
- AVYMOPIIGPZZEH-UHFFFAOYSA-N
- SMILES
- C1=NC(Cl)=CC(N)=C1CO
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N-Bromosuccinimide Price
TRC
- Product number
- A619930
- Product name
- (4-Amino-6-chloropyridin-3-yl)methanol
- Packaging
- 100mg
- Price
- $350
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-0037605
- Product name
- (4-Amino-6-chloropyridin-3-yl)methanol
- Packaging
- 100mg
- Price
- $249
- Updated
- 2021/12/16
AK Scientific
- Product number
- 3013AC
- Product name
- (4-Amino-6-chloropyridin-3-yl)methanol
- Packaging
- 250mg
- Price
- $264
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-0037605
- Product name
- (4-Amino-6-chloropyridin-3-yl)methanol
- Packaging
- 250mg
- Price
- $415
- Updated
- 2021/12/16
American Custom Chemicals Corporation
- Product number
- HCH0365453
- Product name
- (4-AMINO-6-CHLOROPYRIDIN-3-YL)METHANOL
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $500.24
- Updated
- 2021/12/16
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(4-aMino-6-chloropyridin-3-yl)Methanol Chemical Properties,Usage,Production
Synthesis
380626-81-3
846036-96-2
General procedure for the synthesis of (4-amino-6-chloropyridin-3-yl)methanol from ethyl 4-amino-6-chloronicotinate: lithium aluminum hydride (LiAlH4, 1.9 g) was suspended in tetrahydrofuran (THF, 50 mL) and cooled at -78 °C. Subsequently, a solution of ethyl 4-amino-6-chloronicotinate (5.1 g, 25.4 mmol) in tetrahydrofuran (THF, 70 mL) was added slowly and dropwise. The reaction mixture was stirred continuously at -78 °C for 3 h and then gradually warmed up to room temperature. Upon completion of the reaction, a mixture of methanol (MeOH) and ethyl acetate (EtOAc) (1:1, v/v) was slowly added to quench the reaction and the solid was removed by filtration. The filtrate was concentrated and the resulting residue was purified by silica gel column chromatography (eluent ratio petroleum ether (PE):ethyl acetate (EtOAc) = 10:5:1) to give (4-amino-6-chloro-pyridin-3-yl)methanol (2.6 g, 65% yield) as a pale yellow solid.
References
[1] Patent: WO2013/134298, 2013, A1. Location in patent: Page/Page column 40
[2] Journal of Medicinal Chemistry, 2015, vol. 58, # 10, p. 4165 - 4179
[3] Patent: US2005/43309, 2005, A1. Location in patent: Page/Page column 98
[4] Patent: WO2015/120049, 2015, A1. Location in patent: Page/Page column 218
[5] Patent: WO2014/52365, 2014, A1. Location in patent: Page/Page column 180-181
(4-aMino-6-chloropyridin-3-yl)Methanol Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from (4-aMino-6-chloropyridin-3-yl)Methanol manufacturers
Nanjing jinheyou Trading Co., Ltd.
- Product
- (4-aMino-6-chloropyridin-3-yl)Methanol 846036-96-2
- Price
- US $0.00/g
- Min. Order
- 1g
- Purity
- 95%min
- Supply Ability
- 20kg/month
- Release date
- 2019-12-19