4-Chloro-5-Methyl-2-pyridinecarboxylic acid
- Product Name
- 4-Chloro-5-Methyl-2-pyridinecarboxylic acid
- CAS No.
- 882679-14-3
- Chemical Name
- 4-Chloro-5-Methyl-2-pyridinecarboxylic acid
- Synonyms
- 4-Chloro-5-methylpicolinic acid;4-Chloro-5-methylpyridine-2-carboxylic acid;4-Chloro-5-Methyl-2-pyridinecarboxylic acid;4-chloro-5-methyl-2-Pyridine carbocylic acid;2-Pyridinecarboxylic acid, 4-chloro-5-methyl-
- CBNumber
- CB22605452
- Molecular Formula
- C7H6ClNO2
- Formula Weight
- 171.58
- MOL File
- 882679-14-3.mol
4-Chloro-5-Methyl-2-pyridinecarboxylic acid Property
- Boiling point:
- 332.5±37.0 °C(Predicted)
- Density
- 1.390±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 3.44±0.10(Predicted)
- Appearance
- White to off-white Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C993753
- Product name
- 4-Chloro-5-methylpicolinicacid
- Packaging
- 50mg
- Price
- $200
- Updated
- 2021/12/16
- Product number
- 2780DL
- Product name
- 4-Chloro-5-methylpicolinicacid
- Packaging
- 5g
- Price
- $2894
- Updated
- 2021/12/16
- Product number
- CD11035205
- Product name
- 4-Chloro-5-methylpicolinicacid
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $218
- Updated
- 2021/12/16
- Product number
- CM178910
- Product name
- 4-chloro-5-methylpicolinicacid
- Purity
- 95%
- Packaging
- 1g
- Price
- $599
- Updated
- 2021/12/16
- Product number
- CD11035205
- Product name
- 4-Chloro-5-methylpicolinicacid
- Purity
- 95+%
- Packaging
- 1g
- Price
- $644
- Updated
- 2021/12/16
4-Chloro-5-Methyl-2-pyridinecarboxylic acid Chemical Properties,Usage,Production
Synthesis
882679-12-1
882679-14-3
General procedure for the synthesis of 4-chloro-5-methylpicolinic acid from ethyl 4-chloro-5-methylpyridine-2-carboxylate (CAS: 882679-12-1): ethyl 4-chloro-5-methylpyridine-2-carboxylate (10 g, 63 mmol) was dissolved in acetone (80 mL) at 0-5 °C, and potassium permanganate (13 g, 82 mmol) was slowly added to an aqueous solution (500 mL). The reaction mixture was heated to 55 °C and maintained for 1 hour. After completion of the reaction, the mixture was filtered through diatomaceous earth and the filtrate was concentrated under reduced pressure. The aqueous layer was acidified to pH 2-3 with an aqueous solution of 2 M hydrochloric acid.Subsequently, the mixture was extracted with a dichloromethane solution of 10% methanol (3 x 100 mL), the organic layers were combined, dried over anhydrous sodium sulfate, filtered and the solvent was evaporated in vacuum. The residue was crystallized by a solvent mixture of dichloromethane, ether and hexane to afford the target product 4-chloro-5-methylpicolinic acid (5 g, 46% yield). The product was analyzed by LC/MS with ESI m/z (M + H)+ = 172.2.
References
[1] Patent: WO2010/45188, 2010, A1. Location in patent: Page/Page column 73; 74
4-Chloro-5-Methyl-2-pyridinecarboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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