5-Chloro-3-fluoro-2-nitropyridine
- Product Name
- 5-Chloro-3-fluoro-2-nitropyridine
- CAS No.
- 1064783-29-4
- Chemical Name
- 5-Chloro-3-fluoro-2-nitropyridine
- Synonyms
- 5-Chloro-3-fluoro-2-nitropyridine;Pyridine, 5-chloro-3-fluoro-2-nitro-
- CBNumber
- CB22605553
- Molecular Formula
- C5H2ClFN2O2
- Formula Weight
- 176.53
- MOL File
- 1064783-29-4.mol
5-Chloro-3-fluoro-2-nitropyridine Property
- Boiling point:
- 266.7±35.0 °C(Predicted)
- Density
- 1.595±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- pka
- -7.31±0.32(Predicted)
- Appearance
- Off-white to light brown Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- C989338
- Product name
- 5-Chloro-3-fluoro-2-nitropyridine
- Packaging
- 50mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- Z3852
- Product name
- 5-Chloro-3-fluoro-2-nitropyridine
- Packaging
- 100mg
- Price
- $153
- Updated
- 2021/12/16
- Product number
- HCH0367240
- Product name
- 5-CHLORO-3-FLUORO-2-NITROPYRIDINE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $502.81
- Updated
- 2021/12/16
- Product number
- BB20-6958
- Product name
- 5-Chloro-3-fluoro-2-nitro-pyridine
- Purity
- 95%
- Packaging
- 5G
- Price
- $650
- Updated
- 2021/12/16
- Product number
- A163097
- Product name
- 5-Chloro-3-fluoro-2-nitropyridine
- Purity
- 98%
- Packaging
- 5g
- Price
- $697
- Updated
- 2021/12/16
5-Chloro-3-fluoro-2-nitropyridine Chemical Properties,Usage,Production
Synthesis
246847-98-3
1064783-29-4
Example 4 (b) Synthesis of 5-chloro-3-fluoro-2-nitropyridine: In a 250 mL round-bottom flask, 2-amino-5-chloro-3-fluoropyridine (1.5 g, 1.46 mmol) and concentrated sulfuric acid (50 mL) were added with the stirrer installed. The mixture was stirred until completely dissolved and potassium thiosulfate (13 g, 50 mmol) was added in batches. The reaction mixture was stirred overnight, during which the color gradually changed from light green to dark yellow. After completion of the reaction, the mixture was slowly poured into 500 g of ice and stirring was continued for 10 minutes. Subsequently, solid sodium carbonate was added in batches to adjust the pH to 8-10. the products were extracted with ethyl acetate, the organic phases were combined and concentrated to dryness. The crude product was purified by column chromatography (eluent: 10-15% hexane solution of ethyl acetate) to afford 5-chloro-3-fluoro-2-nitropyridine (0.99 g, 5.6 mmol, 54% yield). The structure of the product was confirmed by 1H NMR (d6-DMSO).
References
[1] Patent: US2008/242695, 2008, A1. Location in patent: Page/Page column 34
[2] Patent: US2014/315888, 2014, A1. Location in patent: Paragraph 1071-1072
[3] Patent: WO2017/103824, 2017, A1. Location in patent: Paragraph 00164; 00165
5-Chloro-3-fluoro-2-nitropyridine Preparation Products And Raw materials
Raw materials
Preparation Products
5-Chloro-3-fluoro-2-nitropyridine Suppliers
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- United States
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