5,6-dichloro-3-nitropyridin-2-aMine
- Product Name
- 5,6-dichloro-3-nitropyridin-2-aMine
- CAS No.
- 203794-33-6
- Chemical Name
- 5,6-dichloro-3-nitropyridin-2-aMine
- Synonyms
- 5,6-dichloro-3-nitropyridin-2-aMine;5,6-Dichloro-3-nitro-2-pyridinamine;5,6-dichloro-2-amino-3-nitropyridine;2-Amino-5,6-dichloro-3-nitropyridine;2-Pyridinamine, 5,6-dichloro-3-nitro-;5,6-dichloro-3-nitro-pyridin-2-amine - [D84539]
- CBNumber
- CB22606136
- Molecular Formula
- C5H3Cl2N3O2
- Formula Weight
- 208
- MOL File
- 203794-33-6.mol
5,6-dichloro-3-nitropyridin-2-aMine Property
- Boiling point:
- 347.1±37.0 °C(Predicted)
- Density
- 1.723±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C(protect from light)
- pka
- -3.87±0.50(Predicted)
- Appearance
- Light yellow to yellow Solid
- InChI
- InChI=1S/C5H3Cl2N3O2/c6-2-1-3(10(11)12)5(8)9-4(2)7/h1H,(H2,8,9)
- InChIKey
- DYSLEQUCBXITJX-UHFFFAOYSA-N
- SMILES
- C1(N)=NC(Cl)=C(Cl)C=C1[N+]([O-])=O
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H312Harmful in contact with skin
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P322Specific measures (see …on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P363Wash contaminated clothing before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- D434995
- Product name
- 5,6-dichloro-3-nitropyridin-2-amine
- Packaging
- 50mg
- Price
- $110
- Updated
- 2021/12/16
- Product number
- HCH0366618
- Product name
- 5,6-DICHLORO-3-NITROPYRIDIN-2-AMINE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $501.22
- Updated
- 2021/12/16
- Product number
- CD11168817
- Product name
- 5,6-Dichloro-3-nitropyridin-2-amine
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $59
- Updated
- 2021/12/16
- Product number
- CD11168817
- Product name
- 5,6-Dichloro-3-nitropyridin-2-amine
- Purity
- 95+%
- Packaging
- 1g
- Price
- $149
- Updated
- 2021/12/16
- Product number
- 203794336
- Product name
- 5,6-Dichloro-3-nitropyridin-2-amine
- Packaging
- 1g
- Price
- $157.5
- Updated
- 2021/12/16
5,6-dichloro-3-nitropyridin-2-aMine Chemical Properties,Usage,Production
Synthesis
27048-04-0
203794-33-6
2-Amino-3-nitro-6-chloropyridine (5 g, 28.8 mmol) was used as starting material and suspended in acetic acid (50 mL). To this suspension was added N-chlorosuccinimide (NCS, 4.04 g, 30.2 mmol) and the reaction mixture was stirred at 100 °C for 1 hour. After completion of the reaction, the mixture was cooled to room temperature, NCS (0.385 g, 2.88 mmol) was added again and stirring was continued at 100 °C for 1 hour. At the end of the reaction, the mixture was cooled to room temperature and the solvent was removed by distillation under reduced pressure. The residue was suspended in distilled water (50 mL), stirred and the pH was adjusted to 8 with saturated sodium bicarbonate solution at 0 °C. The solid product was collected by filtration, washed twice with distilled water and subsequently dried under vacuum to afford 5,6-dichloro-3-nitro-2-aminopyridine (5.5 g, 92% yield) as a yellow solid. The product was characterized by 1H-NMR (DMSO-d6): δ 8.33 (brs, 2H), 8.59 (s, 1H).
References
[1] Patent: US9567330, 2017, B2. Location in patent: Page/Page column 40
[2] Bioorganic and Medicinal Chemistry, 1997, vol. 5, # 12, p. 2129 - 2132
[3] Patent: US2013/184240, 2013, A1. Location in patent: Paragraph 0621; 0622; 0623
5,6-dichloro-3-nitropyridin-2-aMine Preparation Products And Raw materials
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