Nepicastat hydrochloride

ChemicalBook > CAS DataBase List > Nepicastat hydrochloride

Nepicastat hydrochloride

Product Name: Nepicastat hydrochloride
CAS No.: 170151-24-3
Chemical Name: Nepicastat hydrochloride
Synonyms: SYN-117 HCl;Nepicastat HCl, >=99%;SYN-117 hydrochloride;Nepicastat (SYN117)HCI;NEPICASTAT HYDROCHLORIDE;Nepicastat HCl (SYN-117);Nepicastat (SYN-117) HCl;RS-25560-197 hydrochloride);Nepicastat (SYN-117) hydrochloride;Nepicastat hydrochloride USP/EP/BP
CBNumber: CB22611129
Molecular Formula: C14H16ClF2N3S
Formula Weight: 331.81
MOL File: 170151-24-3.mol

Less

Nepicastat hydrochloride Property

storage temp.: Inert atmosphere,Store in freezer, under -20°C
solubility: DMSO: soluble10mg/mL, clear
form: powder
color: white to beige
InChIKey: DIPDUAJWNBEVOY-PPHPATTJSA-N

Less

Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26
WGK Germany: 3

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0940
Product name: Nepicastat hydrochloride
Purity: ≥95% (HPLC)
Packaging: 5mg
Price: $115
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML0940
Product name: Nepicastat hydrochloride
Purity: ≥95% (HPLC)
Packaging: 25mg
Price: $462
Updated: 2024/03/01

Cayman Chemical

Product number: 22126
Product name: Nepicastat (hydrochloride)
Packaging: 1mg
Price: $33
Updated: 2024/03/01

Cayman Chemical

Product number: 22126
Product name: Nepicastat (hydrochloride)
Packaging: 5mg
Price: $96
Updated: 2024/03/01

Cayman Chemical

Product number: 22126
Product name: Nepicastat (hydrochloride)
Packaging: 10mg
Price: $176
Updated: 2024/03/01

Less

Nepicastat hydrochloride Chemical Properties,Usage,Production

Description

Nepicastat is an inhibitor of dopamine β-hydroxylase (DBH; IC₅₀ = 9 nM for the purified human enzyme). It is selective for DBH over a panel of 12 enzymes and 13 neurotransmitter receptors (IC₅₀s or K_is = >10 μM). Nepicastat dose-dependently reduces norepinephrine content and increases dopamine content in the mesenteric artery, left ventricle, and cerebral cortex in spontaneously hypertensive rats, as well as in the renal artery, left ventricle, and cerebral cortex in beagle dogs. It attenuates increases in diastolic blood pressure and heart rate induced by preganglionic sympathetic nerve stimulation in pithed spontaneously hypertensive rats when administered orally at doses of 10 and 30 mg/kg. Nepicatstat (50 mg/kg) reduces the progressive ratio response for cocaine, but not food or sucrose pellets, in rats. It also reduces reinstatement of cocaine-seeking behavior induced by cues, yohimbine , or foot-shock in rats.

Uses

Nepicastat Hydrochloride is a potent and selective dopamine β-hydrolase inhibitor. Used in cardiovascular treatment where deficiencies in ventricles results in heart failure.

storage

Store at -20°C

References

[1]. stanley wc, li b, bonhaus dw, et al. catecholamine modulatory effects of nepicastat (rs-25560-197), a novel, potent and selective inhibitor of dopamine-beta-hydroxylase. br j pharmacol, 1997, 121(8): 1803-1809.
[2]. stanley wc, lee k, johnson lg, et al. cardiovascular effects of nepicastat (rs-25560-197), a novel dopamine beta-hydroxylase inhibitor. j cardiovasc pharmacol, 1998, 31(6): 963-970.
[3]. devoto p, flore g, saba p, et al. the dopamine beta-hydroxylase inhibitor nepicastat increases dopamine release and potentiates psychostimulant-induced dopamine release in the prefrontal cortex. addict biol, 2014, 19(4): 612-622.

Nepicastat hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

Less

Nepicastat hydrochloride Suppliers

China 82 India 1 United Kingdom 2 United States 19 Global 104

Adamas Reagent, Ltd.

Tel: 400-6009262 16621234537
Fax: 021-64823266
Email: chenyj@titansci.com
Country: China
ProdList: 14103
Advantage: 59

Dalian Meilun Biotech Co., Ltd.

Tel: 0411-62910999 13889544652
Email: meilunui@163.com
Country: China
ProdList: 4727
Advantage: 58

Shanghai civi chemical technology co.,Ltd

Tel: 86-21-34053660
Fax: 86-21-34053661
Email: sale@labgogo.com
Country: China
ProdList: 9865
Advantage: 52

NCE Biomedical Co.,Ltd.

Tel: 4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988
Fax: +86-27-87599188
Country: China
ProdList: 1493
Advantage: 55

Haoyuan Chemexpress Co., Ltd.

Tel: 021-58950125
Fax: (86) 21-58955996
Email: info@chemexpress.com
Country: China
ProdList: 7552
Advantage: 61

DONGSHENG CHIRAL PHARMA

Tel: 180000000
Email: 3755454181@qq.com
Country: China
ProdList: 421
Advantage: 55

Shanghai HuanChuan Industry Co.,Ltd.

Tel: 021-61478794
Fax: 021-61478794
Email: sales@hcshhai.com
Country: China
ProdList: 9793
Advantage: 50

AdooQ Bioscience CHINA

Tel: 025-58849295 18951903616;
Fax: 025-68650336
Email: info@adooq.cn
Country: China
ProdList: 2990
Advantage: 60

Hubei Jusheng Technology Co.,Ltd

Tel: 027-59599241 18871490274
Fax: 027-59599241
Email: 1400878000@qq.com
Country: China
ProdList: 9958
Advantage: 58

LETOPHARM LIMITED

Tel: +86-21-5821 5861
Fax: +86-21-5106 2861
Email: sales@letopharm.com
Country: China
ProdList: 2384
Advantage: 58

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4512
Advantage: 55

Shanghaizehan biopharma technology co., Ltd.

Tel: 021-61350663 13052117465
Fax: 021-61350662
Email: sales@zehanbiopharma.com
Country: China
ProdList: 1009
Advantage: 55

D&C Chemicals

Tel: +86-21-58447131
Fax: +86-21-61642470
Email: 1724405207@qq.com
Country: China
ProdList: 472
Advantage: 55

SPIRO PHARMA

Tel
Fax: -
Email: eric_feng1954@126.com
Country: China
ProdList: 9248
Advantage: 55

Taizhou GreenChem Pharmaceutical Co., Ltd.

Tel: 0514-86654616 15366892466
Email: greenchem@tzglmk.com
Country: China
ProdList: 498
Advantage: 56

Shanghai Send Pharmaceutical Technology Co., Ltd.

Tel: 021-58088081 Q3252066219
Fax: QQ3382968513
Email: danping@shsendpharm.com
Country: China
ProdList: 3130
Advantage: 55

Codow Chemical Co.,Ltd.

Tel: 18620099427
Fax: +86-20-62619665
Email: amy@howeipharm.com
Country: China
ProdList: 17687
Advantage: 55

Guangzhou QiYun Biotechnology Co., Ltd.

Tel: 020-61288194 61288195
Fax: 020-61288700
Email: 505721671@qq.com
Country: China
ProdList: 3866
Advantage: 58

Shanghai QianYan Bio-technology Co., Ltd

Tel: 02781293128
Email: orders@biochemsafebuy.com
Country: China
ProdList: 9923
Advantage: 55

Lancrix Chemicals

Tel: 86-21-50817262
Fax: 86-21-57712035
Email: sales@lancrix.com
Country: China
ProdList: 1502
Advantage: 55

Raw material medicin reagent co.,Ltd

Tel
Email: sales@njromanme.com
Country: China
ProdList: 4529
Advantage: 58

ShangHai Biochempartner Co.,Ltd

Tel: 177-54423994 17754423994
Fax: QQ:2853530913
Email: 2853530910@QQ.com
Country: China
ProdList: 8011
Advantage: 62

Beijing Solarbio Science & Tecnology Co., Ltd.

Tel: 010-50973130 4009686088
Email: 3193328036@qq.com
Country: China
ProdList: 29785
Advantage: 68

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Chemleader Biomedical Co., Limited.

Tel: 021-58180488
Fax: 021-58180499
Email: sales@Medchemleader.com
Country: China
ProdList: 1005
Advantage: 58

Chengdu Saiousi Pharmaceutical Co., Ltd

Tel: 028-64971018 18108168130
Fax: 86 028-64971018
Country: China
ProdList: 1781
Advantage: 55

Shanghai Biopharmaleader Co., Ltd.

Tel: +86 18721201413
Fax: +86 (21) 5775-8967
Email: sales@biopharmaleader.com
Country: China
ProdList: 1720
Advantage: 58

Amatek Scientific Co. Ltd.

Tel: 0512-56316828
Fax: 0512-56316826
Email: info@amateksci.com
Country: China
ProdList: 28810
Advantage: 58

Aikon International Limited

Tel: 025-66113011 13155353615
Fax: (7)02557626880
Email: qzhang@aikonchem.com
Country: China
ProdList: 15394
Advantage: 58

Angel Pharmatech, Ltd.

Tel: 17317130613
Fax: QQ3358272972
Email: 3358272972@qq.com
Country: China
ProdList: 3251
Advantage: 58

Guangzhou Tomums Life Science Co., Ltd.

Tel: 020-31155029 18902330969
Fax: 020-31155029
Email: sales@tomums.cn
Country: China
ProdList: 4696
Advantage: 58

Taizhou Crene Biotechnology Co. Ltd.

Tel: +86-0576-88813233 +86-13396860566
Email: sales@pharm-intermediates.com
Country: China
ProdList: 1990
Advantage: 58

Zhejiang J&C Biological Technology Co.,Limited

Tel: +1-2135480471 +1-2135480471
Email: sales@sarms4muscle.com
Country: China
ProdList: 10473
Advantage: 58

Labnetwork lnc.

Tel: +86-27-50766799 +8618062016861
Email: contact@labnetwork.com
Country: China
ProdList: 19987
Advantage: 58

Hefei Hirisun Pharmatech Co., Ltd

Tel: +8615056975894
Fax: 86-0551-62678551
Email: shawn@hirisunpharm.com
Country: CHINA
ProdList: 9911
Advantage: 58

Dideu Industries Group Limited

Tel: +86-29-89586680 +86-15129568250
Email: 1026@dideu.com
Country: China
ProdList: 22883
Advantage: 58

Wuhan Monad Medicine Tech Co.,LTD

Tel: 02768782018 18771942761
Email: sales01@whmonad.com
Country: CHINA
ProdList: 979
Advantage: 58

HANGZHOU CLAP TECHNOLOGY CO.,LTD

Tel: 86-571-88216897,88216896 13588875226
Fax: 86-571-88216895
Email: sales@hzclap.com
Country: CHINA
ProdList: 6312
Advantage: 58

Chemwill Asia Co.,Ltd.

Tel: 86-21-51086038
Fax: 86-21-51861608
Email: chemwill_asia@126.com
Country: CHINA
ProdList: 23912
Advantage: 58

DC Chemicals

Tel: 021-58447131 13564518121
Email: sales@dcchemicals.com
Country: China
ProdList: 9409
Advantage: 58

Changzhou Chenhong Biotechnology Co., Ltd.

Tel: 0519-85788828 13775037613
Email: sales@chemrenpharm.com
Country: China
ProdList: 3600
Advantage: 58

Beijing xinyanhui pharmaceutical research and development co., LTD

Tel: 13969155946
Email: 1461866103@qq.com
Country: China
ProdList: 16111
Advantage: 58

career henan chemical co

Tel: +86-0371-86658258 +8613203830695
Fax: 0086-371-86658258
Email: factory@coreychem.com
Country: China
ProdList: 29811
Advantage: 58

Absin Bioscience Inc.

Tel: 021-38015121 15000105423
Email: wulan@absin.cn
Country: China
ProdList: 24731
Advantage: 58

Shanghai hongqu biomedical technology co. LTD

Tel: 88888888888
Email: hongquchem@qq.com
Country: China
ProdList: 5132
Advantage: 58

Shanghai Luofa Biochemical Technology Co., Ltd.

Tel: 021-51111890 15317326293
Email: sales@molnova.com
Country: China
ProdList: 4195
Advantage: 58

Wuhan Yanzhe Technology Co., Ltd

Tel: 15527250409
Fax: QQ：2692360204
Email: wenhaotian12@163.com
Country: China
ProdList: 4495
Advantage: 58

Energy Chemical

Tel: 021-58432009 400-005-6266
Fax: 021-58436166
Email: marketing@energy-chemical.com
Country: China
ProdList: 44918
Advantage: 58

Abmole Bioscience Inc.

Tel: 021-50967598 02150967598
Email: sales@abmole.cn
Country: China
ProdList: 4494
Advantage: 58

Zhengzhou convergence chemical co., LTD

Tel: 0371-0371-55153829 18003835034
Fax: 18003835034（微信）
Email: 2853979819@qq.com
Country: China
ProdList: 9719
Advantage: 58

Less

View Lastest Price from Nepicastat hydrochloride manufacturers

Wuhan Monad Medicine Tech Co.,LTD

Product: Nepicastat HCl 170151-24-3
Price: US $50.00/KG
Min. Order: 1Kg/Bag
Purity: 99.99%
Supply Ability: 20 tons/month
Release date: 2021-04-19

Career Henan Chemical Co

Product: Nepicastat hydrochloride 70151-24-3
Price: US $2.00/KG
Min. Order: 1g
Purity: 98%min
Supply Ability: ask
Release date: 2020-01-08

170151-24-3, Nepicastat hydrochlorideRelated Search:

Disulfiram

NEPICASTAT HYDROCHLORIDE

Nepicastat HCl (SYN-117),Nepicastat hydrochloride,

Nepicastat (SYN-117) HCl

Nepicastat HCl (SYN-117)

4-(aminomethyl)-3-[(2S)-5,7-difluoro-1,2,3,4-tetrahydronaphthalen-2-yl]-1H-imidazole-2-thione

(S)-5-(AMinoMethyl)-1-(5,7-difluoro-1,2,3,4-tetrahydronaphthalen-2-yl)-1H-iMidazole-2(3H)-thione hydrochloride

Nepicastat (SYN117)HCI

RS 25560-197 Nepicastat hydrochloride

5-(Aminomethyl)-1-[(2S)-5,7-difluoro-1,2,3,4-tetrahydro-2-naphthalenyl]-1,3-dihydro-2H-imidazole-2-thione hydrochloride

5-(Aminomethyl)-1-[5,7-difluoro-1,2,3,4-tetrahydronaphthalen-2(S)-yl]-2,3-dihydro-1H-imidazole-2-thione hydrochloride

Nepicastat HCl, >=99%

(S)-5-(Aminomethyl)-1-(5,7-difluoro-1,2,3,4-tetrahydronaphthalen-2-yl)-1H-imidazole-2(3H)-thio

Nepicastat (SYN-117) hydrochloride

Nepicastat Hydrochloride (SYN-117 hydrochloride

RS-25560-197 hydrochloride)

SYN-117 HCl

SYN-117 hydrochloride

SYN-117 HYDROCHLORIDE;RS-25560-197 HYDROCHLORIDE

Nepicastat hydrochloride USP/EP/BP

4-(aminomethyl)-3-[(2S)-5,7-difluoro-1,2,3,4-tetrahydronaphthalen-2-yl]-1H-imidazole-2-thione,hydrochloride

2H-Imidazole-2-thione,5-(aminomethyl)-1-[(2S)-5,7-difluoro-1,2,3,4-tetrahydro-2-naphthalenyl]-1,3-dihydro-,hydrochloride (1:1)

(S)-5-(Aminomethyl)-1-(5,7-difluoro-1,2,3,4-tetrahydronaphthalen-2-yl)-1,3-dihydro-2H-imidazole-2-thione hydrochloride

Dopamine beta-monooxygenase,Dopamine beta-hydroxylase,Dopamine β-monooxygenase,Nepicastat hydrochloride,Nepicastat,SYN117,SYN-117,Dopamine β-hydroxylase,Inhibitor,SYN 117,inhibit

170151-24-3

70151-24-3

C14H15F2N3SHCl

C14H16ClF2N3S

C14H15F2N3SClH

Inhibitors

Inhibitor