4-Methoxy-1H-indole-1-carboxylic acid tert-butyl ester
- Product Name
- 4-Methoxy-1H-indole-1-carboxylic acid tert-butyl ester
- CAS No.
- 1093759-59-1
- Chemical Name
- 4-Methoxy-1H-indole-1-carboxylic acid tert-butyl ester
- Synonyms
- 1-Boc-4-methoxyindole;Tert-butyl 4-methoxyindole-1-carboxylate;4-Methoxy-1H-indole-1-carboxylic acid tert-butyl ester;1H-Indole-1-carboxylic acid, 4-methoxy-, 1,1-dimethylethyl ester
- CBNumber
- CB22614377
- Molecular Formula
- C14H17NO3
- Formula Weight
- 247.29
- MOL File
- 1093759-59-1.mol
4-Methoxy-1H-indole-1-carboxylic acid tert-butyl ester Property
- Boiling point:
- 357.3±34.0 °C(Predicted)
- Density
- 1.10
- storage temp.
- Sealed in dry,Store in freezer, under -20°C
- Appearance
- Colorless to light pink Liquid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B700798
- Product name
- tert-Butyl4-Methoxy-1H-indole-1-carboxylate
- Packaging
- 1g
- Price
- $110
- Updated
- 2021/12/16
- Product number
- 1841AA
- Product name
- tert-Butyl4-methoxy-1H-indole-1-carboxylate
- Packaging
- 250mg
- Price
- $140
- Updated
- 2021/12/16
- Product number
- CHM0143220
- Product name
- N-BOC-4-METHOXYINDOLE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $498.32
- Updated
- 2021/12/16
- Product number
- 1841AA
- Product name
- tert-Butyl4-methoxy-1H-indole-1-carboxylate
- Packaging
- 5g
- Price
- $729
- Updated
- 2021/12/16
- Product number
- A220426
- Product name
- tert-Butyl4-methoxy-1H-indole-1-carboxylate
- Purity
- 97%
- Packaging
- 250mg
- Price
- $19
- Updated
- 2021/12/16
4-Methoxy-1H-indole-1-carboxylic acid tert-butyl ester Chemical Properties,Usage,Production
Synthesis
4837-90-5
24424-99-5
1093759-59-1
General procedure for the synthesis of N-Boc-4-methoxyindole from 4-methoxyindole and di-tert-butyl dicarbonate: 1.6 g of 4-methoxyindole was dissolved in 20 mL of acetonitrile, followed by the addition of 2.6 g of di-tert-butyl dicarbonate and 0.03 g of 4-dimethylaminopyridine (DMAP). The reaction mixture was stirred at room temperature overnight. After completion of the reaction, the mixture was poured into a pH 2 buffer solution and extracted with ethyl acetate (EtOAc). The organic phase was washed with saturated sodium chloride (NaCl) solution and dried over anhydrous magnesium sulfate (MgSO4). After concentration under reduced pressure to remove the solvent, the residue was purified by silica gel column chromatography using a gradient elution of cyclohexane/ethyl acetate (98/2 v/v to 95/5 v/v). 2.4 g of N-Boc-4-methoxyindole was finally obtained.
References
[1] Angewandte Chemie, International Edition, 2009, vol. 48, # 23, p. 4235 - 4238
[2] Tetrahedron, 2009, vol. 65, # 34, p. 6877 - 6881
[3] Synthesis, 2009, # 21, p. 3617 - 3632
[4] Patent: WO2007/147874, 2007, A1. Location in patent: Page/Page column 148-149
[5] Patent: WO2011/28580, 2011, A1. Location in patent: Page/Page column 19; 20
4-Methoxy-1H-indole-1-carboxylic acid tert-butyl ester Preparation Products And Raw materials
Raw materials
Preparation Products
4-Methoxy-1H-indole-1-carboxylic acid tert-butyl ester Suppliers
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