Methyl 5-broMo-6-chloropyridine-2-carboxylate

Product Name: Methyl 5-broMo-6-chloropyridine-2-carboxylate
CAS No.: 1214353-79-3
Chemical Name: Methyl 5-broMo-6-chloropyridine-2-carboxylate
Synonyms: Methyl 5-broMo-6-chloropicolinate;Methyl 5-broMo-6-chloropyridine-2-carboxylate;5-Bromo-6-chloro-pyridine-2-carboxylic acid methyl ester;2-Pyridinecarboxylic acid, 5-bromo-6-chloro-, methyl ester
CBNumber: CB22616689
Molecular Formula: C7H5BrClNO2
Formula Weight: 250.48
MOL File: 1214353-79-3.mol

More

Less

Methyl 5-broMo-6-chloropyridine-2-carboxylate Property

Melting point:: 119-121°
Boiling point:: 338.8±37.0 °C(Predicted)
Density: 1.684±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: -3.38±0.10(Predicted)
Appearance: White to off-white Solid
InChI: InChI=1S/C7H5BrClNO2/c1-12-7(11)5-3-2-4(8)6(9)10-5/h2-3H,1H3
InChIKey: WCWGHRWBXIRYFR-UHFFFAOYSA-N
SMILES: C1(C(OC)=O)=NC(Cl)=C(Br)C=C1

More

Less

Safety

HS Code: 9999999999

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

TRC

Product number: M296653
Product name: Methyl5-Bromo-6-chloropicolinate
Packaging: 100mg
Price: $65
Updated: 2021/12/16

Frontier Specialty Chemicals

Product number: M13850
Product name: Methyl5-bromo-6-chloropyridine-2-carboxylate
Packaging: 250mg
Price: $60
Updated: 2021/12/16

Apolloscientific

Product number: OR928942
Product name: Methyl5-bromo-6-chloropyridine-2-carboxylate
Purity: 97%
Packaging: 500mg
Price: $125
Updated: 2021/12/16

Frontier Specialty Chemicals

Product number: M13850
Product name: Methyl5-bromo-6-chloropyridine-2-carboxylate
Packaging: 1g
Price: $180
Updated: 2021/12/16

Matrix Scientific

Product number: 188105
Product name: Methyl 5-bromo-6-chloropyridine-2-carboxylate
Packaging: 1g
Price: $278
Updated: 2021/12/16

More

Less

Methyl 5-broMo-6-chloropyridine-2-carboxylate Chemical Properties,Usage,Production

Synthesis

29682-15-3

1214353-79-3

Methyl 5-bromopyridine-2-carboxylate (CAS 29682-15-3, 50 g, 0.23 mol) was mixed with m-CPBA (CAS 937-14-4, 80 g, 0.46 mol) in 400 mL of dry dichloromethane, heated to 60 °C and maintained the reaction for 20 hours. Upon completion of the reaction, the reaction was quenched with saturated sodium sulfite solution followed by extraction with ethyl acetate (2 x 200 mL). The organic layer was washed with brine (2 x 200 mL) and evaporated to dryness. The residue was purified by column chromatography (silica gel, 300 g, with a petroleum ether solution of 15% ethyl acetate as eluent) to give 5-bromo-2-(methoxycarbonyl)pyridine 1-oxide (30 g, 0.13 mol) as a brown oil. The oily substance was slowly added to phosphorus trichloride (CAS 10025-87-3, 80 mL) at 0 °C. The addition process lasted for 1 h. The mixture was then heated to 95 °C and kept for 1 h. The reaction was completed by evaporation. At the end of the reaction, the solvent was removed by evaporation and the residue was dissolved in water (50 mL) and extracted with ethyl acetate (3 x 50 mL). The organic layers were combined and evaporated to dryness to give the white solid product methyl 5-bromo-6-chloropyridine-2-carboxylate (19 g, 59% yield); mass spectrum (EI): m/e = 249.9 [M + H]+.

References

[1] Patent: US2012/316147, 2012, A1. Location in patent: Page/Page column 32
[2] Patent: WO2012/168350, 2012, A1
[3] Patent: WO2014/86806, 2014, A1
[4] Patent: WO2014/86705, 2014, A1
[5] Journal of Medicinal Chemistry, 2015, vol. 58, # 10, p. 4266 - 4277

Methyl 5-broMo-6-chloropyridine-2-carboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

Methyl 5-broMo-6-chloropyridine-2-carboxylate Suppliers

China 71 India 2 United States 5 Global 78

Shaanxi Imano Pharmaceutical Technology Co., Ltd

Tel: 15683496527 18220923020
Email: 630940531@qq.com
Country: China
ProdList: 490
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 94644
Advantage: 76

Carbott PharmTech Inc.

Tel: 0535-6385396
Fax: +86 (535) 638-9971
Email: info@carbottpharm.com
Country: China
ProdList: 957
Advantage: 56

Jia Xing Isenchem Co.,Ltd

Tel: 0573-85285100 18627885956
Fax: 0573-85285100
Email: isenchem@163.com
Country: China
ProdList: 9309
Advantage: 66

Adamas Reagent, Ltd.

Tel: 400-6009262 16621234537
Fax: 021-64823266
Email: chenyj@titansci.com
Country: China
ProdList: 14101
Advantage: 59

Shanghai Longsheng chemical Co.,Ltd.

Tel: 021-58099652-8005 13585536065
Fax: 021-58099609
Email: bin.wu@shlschem.com
Country: China
ProdList: 9883
Advantage: 59

Hebei Summedchem Co.,Ltd

Tel: 0319-5801333-8008 15630992918
Email: sales@summedchem.com
Country: China
ProdList: 965
Advantage: 58

Bide Pharmatech Ltd.

Tel: 400-164-7117 13681763483
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
ProdList: 39966
Advantage: 60

ShangHai AmK Pharmaceutical Technology Co., Ltd.

Tel: 微信 17321281695 18019252918
Fax: 17321281695
Email: sale@amkchem.com
Country: China
ProdList: 15136
Advantage: 55

Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.

Tel: 025-66028182 18626450290
Email: yftan@aikonchem.com
Country: China
ProdList: 16679
Advantage: 50

1214353-79-3, Methyl 5-broMo-6-chloropyridine-2-carboxylateRelated Search:

Pyridinium tribromide Ethyl 5-broMo-6-chloropicolinate 5-broMo-6-chloropicolinaldehyde 5-BroMo-6-chloronicotinaldehyde 5-BroMo-6-chloropicolinonitrile 5-bromo-6-chloronicotinonitrile

Methyl 5-broMo-6-chloropyridine-2-carboxylate

Methyl 5-broMo-6-chloropicolinate

5-Bromo-6-chloro-pyridine-2-carboxylic acid methyl ester

2-Pyridinecarboxylic acid, 5-bromo-6-chloro-, methyl ester

1214353-79-3