5-broMo-2-Methoxyisonicotinaldehyde
- Product Name
- 5-broMo-2-Methoxyisonicotinaldehyde
- CAS No.
- 936011-17-5
- Chemical Name
- 5-broMo-2-Methoxyisonicotinaldehyde
- Synonyms
- 5-broMo-2-Methoxyisonicotinaldehyde;5-Bromo-2-methoxy-pyridin-4-carbaldehyde;2-Methoxy-5-Bromo pyridine-4-carbaldehyde;5-Bromo-2-methoxy-pyridine-4-carbaldehyde;5-Bromo-2-methoxypyridine-4-carboxaldehyde;4-Pyridinecarboxaldehyde, 5-bromo-2-methoxy-;tert-butyl (2R)-2-(5-bromo-4-methyl-4H-1,2,4-triazol-3-yl)pyrr olidine-1-carboxylate
- CBNumber
- CB22617666
- Molecular Formula
- C7H6BrNO2
- Formula Weight
- 216.03
- MOL File
- 936011-17-5.mol
5-broMo-2-Methoxyisonicotinaldehyde Property
- Boiling point:
- 273.6±35.0 °C(Predicted)
- Density
- 1.606±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- -0.95±0.18(Predicted)
- Appearance
- White to light yellow Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
N-Bromosuccinimide Price
- Product number
- B429355
- Product name
- 5-bromo-2-methoxyisonicotinaldehyde
- Packaging
- 25g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- CS-W022310
- Product name
- 5-Bromo-2-methoxyisonicotinaldehyde
- Purity
- 99.54%
- Packaging
- 5g
- Price
- $130
- Updated
- 2021/12/16
- Product number
- CS-W022310
- Product name
- 5-Bromo-2-methoxyisonicotinaldehyde
- Purity
- 99.54%
- Packaging
- 10g
- Price
- $150
- Updated
- 2021/12/16
- Product number
- Z1129
- Product name
- 5-Bromo-2-methoxypyridine-4-carboxaldehyde
- Packaging
- 250mg
- Price
- $238
- Updated
- 2021/12/16
- Product number
- HCH0366881
- Product name
- 5-BROMO-2-METHOXYISONICOTINALDEHYDE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $503.21
- Updated
- 2021/12/16
5-broMo-2-Methoxyisonicotinaldehyde Chemical Properties,Usage,Production
Synthesis
13472-85-0
68-12-2
936011-17-5
General procedure for the synthesis of 5-bromo-2-methoxyisonicotinaldehyde from 5-bromo-2-methoxypyridine and N,N-dimethylformamide: First, a solution of tetrahydrofuran (THF, 0.5 L) with diisopropylamine (22.7 g, 0.22 mol) was cooled down to -30 °C, followed by the slow addition of n-butyllithium (n-BuLi, 140 mL, 0.22 mol). After the addition was completed, the reaction solution was stirred for 30 minutes. Next, the mixture was further cooled to -60 °C and 5-bromo-2-methoxypyridine (35.1 g, 0.19 mol) dissolved in THF (200 mL) was slowly added dropwise, ensuring that the reaction temperature was maintained below -60 °C. After completion of the dropwise addition, stirring of the reaction solution was continued for 1 hour. Subsequently, N,N-dimethylformamide (DMF, 20.4 g, 0.28 mol) was slowly added dropwise at -60 °C, and after completion of the dropwise addition, stirring of the reaction solution was continued for 1 hour. Upon completion of the reaction, the reaction was quenched with saturated aqueous ammonium chloride (NH4Cl, 200 mL) and the reaction mixture was allowed to warm slowly to room temperature. Extraction was performed with ethyl acetate (EtOAc, 200 mL x 2). The organic phases were combined, washed with brine, dried over anhydrous sodium sulfate (Na2SO4), filtered and concentrated under reduced pressure to give the crude product. Finally, the crude product was purified by silica gel column chromatography to obtain the pure 5-bromo-2-methoxyisonicotinaldehyde (26.4 g, yield 64.3%) as a white solid. Nuclear magnetic resonance hydrogen spectrum (1H NMR, 400 MHz, CDCl3) δ 10.28 (s, 1H), 8.40 (s, 1H), 7.16 (s, 1H), 3.95 (s, 3H).
References
[1] Patent: WO2017/218960, 2017, A1. Location in patent: Paragraph 00600
[2] Patent: WO2009/23964, 2009, A1. Location in patent: Page/Page column 30
[3] Patent: WO2014/22528, 2014, A1. Location in patent: Page/Page column 83; 86; 87
[4] Patent: WO2014/19186, 2014, A1. Location in patent: Page/Page column 73
[5] Patent: US2014/94456, 2014, A1. Location in patent: Paragraph 0925-026
5-broMo-2-Methoxyisonicotinaldehyde Preparation Products And Raw materials
Raw materials
Preparation Products
5-broMo-2-Methoxyisonicotinaldehyde Suppliers
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View Lastest Price from 5-broMo-2-Methoxyisonicotinaldehyde manufacturers
- Product
- 5-broMo-2-Methoxyisonicotinaldehyde 936011-17-5
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-14