4-Chloro-5-iodo-2-Methyl-7H-pyrrolo[2,3-d]pyriMidine
- Product Name
- 4-Chloro-5-iodo-2-Methyl-7H-pyrrolo[2,3-d]pyriMidine
- CAS No.
- 1060815-92-0
- Chemical Name
- 4-Chloro-5-iodo-2-Methyl-7H-pyrrolo[2,3-d]pyriMidine
- Synonyms
- 4-Chloro-5-iodo-2-Methyl-7H-pyrrolo[2,3-d]pyriMidine;7H-Pyrrolo[2,3-d]pyrimidine, 4-chloro-5-iodo-2-methyl-
- CBNumber
- CB22619983
- Molecular Formula
- C7H5ClIN3
- Formula Weight
- 293.49
- MOL File
- 1060815-92-0.mol
4-Chloro-5-iodo-2-Methyl-7H-pyrrolo[2,3-d]pyriMidine Property
- Density
- 2.117±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 10.04±0.50(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- AA007E1W
- Product name
- 4-Chloro-5-iodo-2-methyl-7H-pyrrolo[2,3-d]pyrimidine
- Purity
- 96%
- Packaging
- 250mg
- Price
- $113
- Updated
- 2026/05/28
- Product number
- AA007E1W
- Product name
- 4-Chloro-5-iodo-2-methyl-7H-pyrrolo[2,3-d]pyrimidine
- Purity
- 96%
- Packaging
- 1g
- Price
- $274
- Updated
- 2026/05/28
- Product number
- AA007E1W
- Product name
- 4-Chloro-5-iodo-2-methyl-7H-pyrrolo[2,3-d]pyrimidine
- Purity
- 96%
- Packaging
- 5g
- Price
- $1074
- Updated
- 2026/05/28
- Product number
- S83636
- Product name
- 4-chloro-5-iodo-2-methyl-7H-pyrrolo[2,3-d]pyrimidine
- Purity
- 97%
- Packaging
- 5G
- Price
- $600
- Updated
- 2026/05/27
- Product number
- CD11357977
- Product name
- 4-Chloro-5-iodo-2-methyl-7H-pyrrolo[2,3-d]pyrimidine
- Purity
- 97%
- Packaging
- 1g
- Price
- $242
- Updated
- 2026/05/27
4-Chloro-5-iodo-2-Methyl-7H-pyrrolo[2,3-d]pyriMidine Chemical Properties,Usage,Production
Synthesis
71149-52-5
1060815-92-0
The general procedure for the synthesis of 4-chloro-5-iodo-2-methyl-7H-pyrrolo[2,3-d]pyrimidines from 4-chloro-2-methyl-1H-pyrrolo[2,3-d]pyrimidines was as follows: to a solution of 4-chloro-2-methyl-7H-pyrrolo[2,3-d]pyrimidines (400 mg, 2.4 mmol) in methylene chloride (10 mL) was added N-iodosuccinic imide (537 mg, 2.39 mmol). The reaction mixture was stirred at room temperature for 2 hours. Upon completion of the reaction, the organic layer was washed with saturated aqueous sodium sulfite to remove unreacted iodine. The organic layer was dried over anhydrous sodium sulfate, the desiccant was removed by filtration and the filtrate was concentrated under reduced pressure to give a brown solid product. Yield: 330 mg, 1.12 mmol, 47% yield. The product was analyzed by LCMS, m/z 293.8 [M + H]+.
References
[1] Journal of Medicinal Chemistry, 2014, vol. 57, # 3, p. 1097 - 1110
[2] Patent: WO2014/1973, 2014, A1. Location in patent: Page/Page column 64
4-Chloro-5-iodo-2-Methyl-7H-pyrrolo[2,3-d]pyriMidine Preparation Products And Raw materials
Raw materials
Preparation Products
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