2-(4-ethyl-3-iodophenyl)-2-Methylpropanoic acid

ChemicalBook > CAS DataBase List > 2-(4-ethyl-3-iodophenyl)-2-Methylpropanoic acid

2-(4-ethyl-3-iodophenyl)-2-Methylpropanoic acid

Product Name: 2-(4-ethyl-3-iodophenyl)-2-Methylpropanoic acid
CAS No.: 1256584-73-2
Chemical Name: 2-(4-ethyl-3-iodophenyl)-2-Methylpropanoic acid
Synonyms: Alectinib Impurity 14;Alecensa intermediate;Alectinib intermediate A;4-Ethyl-3-iodo-α,α-dimethylbenzeneacetic acid;2-(3-Iodo-4-ethylphenyl)-2-methylpropionic acid;2-(4-ethyl-3-iodophenyl)-2-Methylpropanoic acid;Benzeneacetic acid, 4-ethyl-3-iodo-α,α-dimethyl-;2-(4-ethyl-3-iodophenyl)-2-Methylpropanoic acid-7;4-?Ethyl-?3-?iodo-?α,?α-?dimethylbenzeneaceti?c acid;4-Ethyl-3-iodo-alpha,alpha-dimethylbenzeneacetic acid
CBNumber: CB22623823
Molecular Formula: C12H15IO2
Formula Weight: 318.15
MOL File: 1256584-73-2.mol

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2-(4-ethyl-3-iodophenyl)-2-Methylpropanoic acid Property

Boiling point:: 369.6±27.0 °C(Predicted)
Density: 1.547±0.06 g/cm3(Predicted)
pka: 4.32±0.11(Predicted)
InChI: InChI=1S/C12H15IO2/c1-4-8-5-6-9(7-10(8)13)12(2,3)11(14)15/h5-7H,4H2,1-3H3,(H,14,15)
InChIKey: RUVGXZCQYVEAKQ-UHFFFAOYSA-N
SMILES: C(O)(=O)C(C1=CC=C(CC)C(I)=C1)(C)C

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: E920550
Product name: 2-(4-Ethyl-3-iodophenyl)-2-methylpropanoicAcid
Packaging: 10mg
Price: $45
Updated: 2021/12/16

ChemScene

Product number: CS-M1475
Product name: 2-(4-Ethyl-3-iodophenyl)-2-methylpropanoicacid
Purity: 99.25%
Packaging: 1g
Price: $18
Updated: 2021/12/16

ChemScene

Product number: CS-M1475
Product name: 2-(4-Ethyl-3-iodophenyl)-2-methylpropanoicacid
Purity: 99.25%
Packaging: 25g
Price: $130
Updated: 2021/12/16

AK Scientific

Product number: 5962AQ
Product name: 2-(4-ethyl-3-iodophenyl)-2-methylpropanoicacid
Packaging: 5g
Price: $216.8
Updated: 2021/12/16

ChemScene

Product number: CS-M1475
Product name: 2-(4-Ethyl-3-iodophenyl)-2-methylpropanoicacid
Purity: 99.25%
Packaging: 100g
Price: $299
Updated: 2021/12/16

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2-(4-ethyl-3-iodophenyl)-2-Methylpropanoic acid Chemical Properties,Usage,Production

Uses

2-(4-ethyl-3-iodophenyl)-2-Methylpropanoic acid is an intermediate of Alectinib (C183360), a highly selective and potent anaplastic lymphoma kinase (ALK) inhibitor capable of blocking the resistant gatekeeper mutant, which results in reduced cell growth.

Synthesis

2-(4-ethyl-3-iodophenyl)-2-Methylpropanoic acid is prepared by reacting 4-Ethyl-α,α-dimethylbenzeneacetic acid with N-Iodosuccinimide in Acetic acid for 2h.

2-(4-ethyl-3-iodophenyl)-2-Methylpropanoic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2-(4-ethyl-3-iodophenyl)-2-Methylpropanoic acid manufacturers

hebei hongtan Biotechnology Co., Ltd

Product: 4-Ethyl-3-iodo-alpha,alpha-dimethylbenzeneacetic acid 1256584-73-2
Price: US $30.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 2000kg
Release date: 2024-05-16

Nanjing Fred Technology Co., Ltd

Product: 2-(4-Ethyl-3-iodophenyl)-2-Methylpropanoic acid 1256584-73-2
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1 ton
Release date: 2023-12-29

Shaanxi Dideu Medichem Co. Ltd

Product: 2-(4-ethyl-3-iodophenyl)-2-Methylpropanoic acid 1256584-73-2
Price: US $10000.00-200000.00/KG
Min. Order: 1KG
Purity: 99.0%HPLC
Supply Ability: 500tons
Release date: 2021-03-09

1256584-73-2, 2-(4-ethyl-3-iodophenyl)-2-Methylpropanoic acidRelated Search:

2-(4-ethyl-3-iodophenyl)-2-Methylpropanoic acid

2-(4-ethyl-3-iodophenyl)-2-Methylpropanoic acid-7

4-Ethyl-3-iodo-α,α-dimethylbenzeneacetic acid

4-Ethyl-3-iodo-alpha,alpha-dimethylbenzeneacetic acid

2-(3-Iodo-4-ethylphenyl)-2-methylpropionic acid

Alecensa intermediate

Alectinib Impurity 14

Benzeneacetic acid, 4-ethyl-3-iodo-α,α-dimethyl-

2-(4-ethyl-3-iodophenyl)-2-methylpropanoic acid (alectinib intermediate)

4-?Ethyl-?3-?iodo-?α,?α-?dimethylbenzeneaceti?c acid

Alectinib intermediate A

1256584-73-2