ChemicalBook > CAS DataBase List > 2-(4-ethyl-3-iodophenyl)-2-Methylpropanoic acid

2-(4-ethyl-3-iodophenyl)-2-Methylpropanoic acid

Product Name
2-(4-ethyl-3-iodophenyl)-2-Methylpropanoic acid
CAS No.
1256584-73-2
Chemical Name
2-(4-ethyl-3-iodophenyl)-2-Methylpropanoic acid
Synonyms
Aletinib impurity 14;Alectinib Impurity 14;Alecensa intermediate;Alectinib intermediate A;4-Ethyl-3-iodo-α,α-dimethylbenzeneacetic acid;2-(3-Iodo-4-ethylphenyl)-2-methylpropionic acid;2-(4-ethyl-3-iodophenyl)-2-Methylpropanoic acid;Benzeneacetic acid, 4-ethyl-3-iodo-α,α-dimethyl-;2-(4-ethyl-3-iodophenyl)-2-Methylpropanoic acid-7;4-?Ethyl-?3-?iodo-?α,?α-?dimethylbenzeneaceti?c acid
CBNumber
CB22623823
Molecular Formula
C12H15IO2
Formula Weight
318.15
MOL File
1256584-73-2.mol
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2-(4-ethyl-3-iodophenyl)-2-Methylpropanoic acid Property

Boiling point:
369.6±27.0 °C(Predicted)
Density 
1.547±0.06 g/cm3(Predicted)
pka
4.32±0.11(Predicted)
InChI
InChI=1S/C12H15IO2/c1-4-8-5-6-9(7-10(8)13)12(2,3)11(14)15/h5-7H,4H2,1-3H3,(H,14,15)
InChIKey
RUVGXZCQYVEAKQ-UHFFFAOYSA-N
SMILES
C(O)(=O)C(C1=CC=C(CC)C(I)=C1)(C)C
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
E920550
Product name
2-​(4-​Ethyl-​3-​iodophenyl)​-​2-​methylpropanoicAcid
Packaging
10mg
Price
$45
Updated
2021/12/16
ChemScene
Product number
CS-M1475
Product name
2-(4-Ethyl-3-iodophenyl)-2-methylpropanoicacid
Purity
99.25%
Packaging
1g
Price
$18
Updated
2021/12/16
ChemScene
Product number
CS-M1475
Product name
2-(4-Ethyl-3-iodophenyl)-2-methylpropanoicacid
Purity
99.25%
Packaging
25g
Price
$130
Updated
2021/12/16
AK Scientific
Product number
5962AQ
Product name
2-(4-ethyl-3-iodophenyl)-2-methylpropanoicacid
Packaging
5g
Price
$216.8
Updated
2021/12/16
ChemScene
Product number
CS-M1475
Product name
2-(4-Ethyl-3-iodophenyl)-2-methylpropanoicacid
Purity
99.25%
Packaging
100g
Price
$299
Updated
2021/12/16
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2-(4-ethyl-3-iodophenyl)-2-Methylpropanoic acid Chemical Properties,Usage,Production

Description

2-(4-ethyl-3-iodophenyl)-2-Methylpropanoic acid is a pharmaceutical intermediate compound used in the preparation of anti-tumour drugs such as alectinib, erlotinib and hydrochloric acid neritinib.

Uses

2-(4-ethyl-3-iodophenyl)-2-Methylpropanoic acid is an intermediate of Alectinib (C183360), a highly selective and potent anaplastic lymphoma kinase (ALK) inhibitor capable of blocking the resistant gatekeeper mutant, which results in reduced cell growth.

Synthesis

2-(4-ethyl-3-iodophenyl)-2-Methylpropanoic acid is prepared by reacting 4-Ethyl-α,α-dimethylbenzeneacetic acid with N-Iodosuccinimide in Acetic acid for 2h.

2-(4-ethyl-3-iodophenyl)-2-Methylpropanoic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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2-(4-ethyl-3-iodophenyl)-2-Methylpropanoic acid Suppliers

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View Lastest Price from 2-(4-ethyl-3-iodophenyl)-2-Methylpropanoic acid manufacturers

hebei hongtan Biotechnology Co., Ltd
Product
4-Ethyl-3-iodo-alpha,alpha-dimethylbenzeneacetic acid 1256584-73-2
Price
US $30.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
2000kg
Release date
2024-05-16
Shaanxi Dideu Medichem Co. Ltd
Product
2-(4-ethyl-3-iodophenyl)-2-Methylpropanoic acid 1256584-73-2
Price
US $10000.00-200000.00/KG
Min. Order
1KG
Purity
99.0%HPLC
Supply Ability
500tons
Release date
2021-03-09
Nanjing Fred Technology Co., Ltd
Product
2-(4-Ethyl-3-iodophenyl)-2-Methylpropanoic acid 1256584-73-2
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1 ton
Release date
2023-12-29

1256584-73-2, 2-(4-ethyl-3-iodophenyl)-2-Methylpropanoic acidRelated Search:


  • 2-(4-ethyl-3-iodophenyl)-2-Methylpropanoic acid
  • 2-(4-ethyl-3-iodophenyl)-2-Methylpropanoic acid-7
  • 4-Ethyl-3-iodo-α,α-dimethylbenzeneacetic acid
  • 4-Ethyl-3-iodo-alpha,alpha-dimethylbenzeneacetic acid
  • 2-(3-Iodo-4-ethylphenyl)-2-methylpropionic acid
  • Alecensa intermediate
  • Alectinib Impurity 14
  • Benzeneacetic acid, 4-ethyl-3-iodo-α,α-dimethyl-
  • 2-(4-ethyl-3-iodophenyl)-2-methylpropanoic acid (alectinib intermediate)
  • 4-?Ethyl-?3-?iodo-?α,?α-?dimethylbenzeneaceti?c acid
  • Alectinib intermediate A
  • Aletinib impurity 14
  • 1256584-73-2
  • 1256584-73-2