GSK-256066 (2,2,2-trifluoroacetic acid)

Product Name: GSK-256066 (2,2,2-trifluoroacetic acid)
CAS No.: 1415560-64-3
Chemical Name: GSK-256066 (2,2,2-trifluoroacetic acid)
Synonyms: GSK256066 (2;GSK-256066; GSK 256066;2-trifluoroacetic acid);GSK256066 trifluoroacetate;GSK-256066 (2,2,2-trifluoroacetic acid);GSK256066 Trifluoroacetate,GSK-256066 Trifluoroacetate;6-[[3-[(Dimethylamino)carbonyl]phenyl]sulfonyl]-4-[(3-methoxyphenyl)amino]-8-methyl-3-quinolinecarboxamide 2,2,2-trifluoroacetate (1:1)
CBNumber: CB22624178
Molecular Formula: C29H27F3N4O7S
Formula Weight: 632.61
MOL File: 1415560-64-3.mol

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GSK-256066 (2,2,2-trifluoroacetic acid) Property

storage temp.: Store at -20°C
solubility: DMSO : 50 mg/mL (79.04 mM; Need ultrasonic)
form: Powder
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-1182
Product name: GSK256066(Trifluoroacetate)
Purity: 99.54%
Packaging: 10mg
Price: $300
Updated: 2021/12/16

ChemScene

Product number: CS-1182
Product name: GSK256066(Trifluoroacetate)
Purity: 99.54%
Packaging: 50mg
Price: $864
Updated: 2021/12/16

Chemenu

Product number: CM144217
Product name: 6-((3-(dimethylcarbamoyl)phenyl)sulfonyl)-4-((3-methoxyphenyl)amino)-8-methylquinoline-3-carboxamide2,2,2-trifluoroacetate
Purity: 98%
Packaging: 50mg
Price: $439
Updated: 2021/12/16

Crysdot

Product number: CD31003576
Product name: GSK2560662,2,2-trifluoroaceticacid
Purity: 98+%
Packaging: 50mg
Price: $469
Updated: 2021/12/16

Crysdot

Product number: CD31003576
Product name: GSK2560662,2,2-trifluoroaceticacid
Purity: 98+%
Packaging: 5mg
Price: $91
Updated: 2021/12/16

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GSK-256066 (2,2,2-trifluoroacetic acid) Chemical Properties,Usage,Production

Uses

GSK256066 Trifluoroacetate is a selective and high-affinity phosphodiesterase 4 (PDE) inhibitor, with an IC50 of 3.2 pM for PDE4B. GSK256066 Trifluoroacetate is developed for the research of chronic obstructive pulmonary disease[1].

in vivo

GSK256066 Trifluoroacetate (0.3-100 μg/kg; intratracheally) inhibits the eosinophil number increased in the bronchoalveolar lavage (BAL) in a dose-dependent fashion, in lipopolysaccharide (LPS)- and ovalbumin (OVA)-induced acute pulmonary inflammation rat models.^[2].
GSK256066 Trifluoroacetate inhibits LPS-induced pulmonary neutrophilia, and no emetic episodes are observed in ferrets^[2].

Animal Model:	Male Brown Norway rats(180-200 g)^[2]
Dosage:	0.3-100 μg/kg
Administration:	Intratracheally; 30 minutes before and 6 hours after ovalbumin challenge
Result:	Inhibited the increase in eosinophil number in the BAL in a dose-dependent fashion.

References

[1] Tralau-Stewart CJ, et al. GSK256066, an exceptionally high-affinity and selective inhibitor of phosphodiesterase 4 suitable for administration by inhalation: in vitro, kinetic, and in vivo characterization. J Pharmacol Exp Ther, 2011, 337(1), 145-154. DOI:10.1124/jpet.110.173690
[2] Nials AT, et al. In vivo characterization of GSK256066, a high-affinity inhaled phosphodiesterase 4 inhibitor. J Pharmacol Exp Ther, 2011, 337(1), 137-144. DOI:10.1124/jpet.110.173641

GSK-256066 (2,2,2-trifluoroacetic acid) Preparation Products And Raw materials

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Preparation Products

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GSK-256066 (2,2,2-trifluoroacetic acid) Suppliers

China 25 United States 9 Global 34

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1415560-64-3, GSK-256066 (2,2,2-trifluoroacetic acid)Related Search:

GSK-256066 (2,2,2-trifluoroacetic acid)

6-[[3-[(Dimethylamino)carbonyl]phenyl]sulfonyl]-4-[(3-methoxyphenyl)amino]-8-methyl-3-quinolinecarboxamide 2,2,2-trifluoroacetate (1:1)

GSK256066 trifluoroacetate

GSK-256066; GSK 256066

2-trifluoroacetic acid)

GSK256066 (2

GSK256066 Trifluoroacetate,GSK-256066 Trifluoroacetate

1415560-64-3

C27H26N4O5SC2HF3O2