ChemicalBook > CAS DataBase List > BMS 582949
BMS 582949
- Product Name
- BMS 582949
- CAS No.
- 623152-17-0
- Chemical Name
- BMS 582949
- Synonyms
- CS-2900;PS540446;BMS 582949;BMS582949(HCl);BMS 582949; BMS582949;4-[5-(cyclopropylcarbamoyl)-2-methylanilino]-5-methyl-N-propylpyrrolo[2,1-f][1,2,4]triazine-6-carboxamide;4-[[5-[(Cyclopropylamino)carbonyl]-2-methylphenyl]amino]-5-methyl-N-propylpyrrolo[2,1-f][1,2,4]triazine-6-carboxamide;Pyrrolo[2,1-f][1,2,4]triazine-6-carboxamide, 4-[[5-[(cyclopropylamino)carbonyl]-2-methylphenyl]amino]-5-methyl-N-propyl-
- CBNumber
- CB22627609
- Molecular Formula
- C22H26N6O2
- Formula Weight
- 406.48
- MOL File
- 623152-17-0.mol
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BMS 582949 Property
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- form
- A crystalline solid
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Safety
- HS Code
- 2934999090
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N-Bromosuccinimide Price
Cayman Chemical
- Product number
- 22892
- Product name
- BMS 582949
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $77
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 22892
- Product name
- BMS 582949
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $340
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 22892
- Product name
- BMS 582949
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $1036
- Updated
- 2024/03/01
AK Scientific
- Product number
- 3947BB
- Product name
- Bms-582949
- Packaging
- 25mg
- Price
- $1251
- Updated
- 2021/12/16
Axon Medchem
- Product number
- Axon2856
- Product name
- BMS582949
- Purity
- 98%
- Packaging
- 25mg
- Price
- $599.5
- Updated
- 2021/12/16
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BMS 582949 Chemical Properties,Usage,Production
Biological Activity
bms-582949 is a p38 mapk inhibitorp38r map kinase plays a key role in regulating the biosynthesis of various inflammatory cytokines, such as tumor necrosis factor alpha and interleukin-1β. thus, p38r inhibitors are considered as a promising therapy for inflammatory disease treatment.
in vitro
bms-582949 was found to be 450-fold selective over jnk2, a map kinase involved in inflammation, and 190-fold selective against raf. moreover, the binding mode of bms-582949 with p38r was further demonstrated by x-ray crystallographic analyses [1].
in vivo
in a pseudoestablished rat adjuvant arthritis model, bms-582949 at doses of 10 and 100 mg/kg was found to display dose-dependent reduction in paw swelling with qd dosing. in addition, with bid dosing at doses of 1 and 5 mg/kg, bms-582949 showed improved efficacy, resulting in great reduction in paw swelling. moreover, the statistically significant reduction in paw swelling was also observed with the treatment of bms-582949 at doses as low as 0.3 mg/kg bid [1].
target
| Target | Value |
| p38 MAPK (Cell-free assay) | < td style="border-bottom: 1px dotted #ccc;padding: 5px;"> 13 nM
IC 50
13 nm
References
[1]. liu c, et al. discovery of 4-(5-(cyclopropylcarbamoyl)-2-methylphenylamino)-5-methyl- n-propylpyrrolo[1,2-f][1,2,4]triazine-6-carboxamide (bms-582949), a clinical p38α map kinase inhibitor for the treatment of inflammatory diseases. j med chem. 2010 sep 23;53(18):6629-39.
[2]. emami h, et al. the effect of bms-582949, a p38 mitogen-activated protein kinase (p38 mapk) inhibitor on arterial inflammation: a multicenter fdg-pet trial. atherosclerosis. 2015 jun;240(2):490-6.
BMS 582949 Preparation Products And Raw materials
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