ChemicalBook > CAS DataBase List > CB 30865

CB 30865

Product Name: CB 30865
CAS No.: 206275-15-2
Chemical Name: CB 30865
Synonyms: ZM242421;CB 30865;ZM-242421;ZM 242421;4-[[(7-Bromo-1,4-dihydro-2-methyl-4-oxo-6-quinazolinyl)methyl]-2-propynylamino]-N-(3-pyridinylmethyl)benzamide;4-(((7-bromo-2-methyl-4-oxo-3,4-dihydroquinazolin-6-yl)methyl)(prop-2-yn-1-yl)amino)-n-(pyridin-3-ylmethyl)benzamide;Benzamide, 4-[[(7-bromo-3,4-dihydro-2-methyl-4-oxo-6-quinazolinyl)methyl]-2-propyn-1-ylamino]-N-(3-pyridinylmethyl)-
CBNumber: CB22627674
Molecular Formula: C26H22BrN5O2
Formula Weight: 516.38918
MOL File: 206275-15-2.mol

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CB 30865 Property

Density: 1.38±0.1 g/cm3(Predicted)
storage temp.: Store at 0-8 °C
solubility: DMSO : 33.33 mg/mL (64.54 mM; Need ultrasonic)H2O : < 0.1 mg/mL (insoluble)
form: Powder
pka: 14.31±0.46(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

ApexBio Technology

Product number: A3286
Product name: CB30865
Packaging: 5mg
Price: $419
Updated: 2021/12/16

ChemScene

Product number: CS-1152
Product name: CB30865
Purity: 98.05%
Packaging: 10mg
Price: $443
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0132427
Product name: 4-[[(7-BROMO-1,4-DIHYDRO-2-METHYL-4-OXO-6-QUINAZOLINYL)METHYL]-2-PROPYNYLAMINO]-N-(3-PYRIDINYLMETHYLBENZAMIDE
Purity: 95.00%
Packaging: 5MG
Price: $503.92
Updated: 2021/12/16

ApexBio Technology

Product number: A3286
Product name: CB30865
Packaging: 10mg
Price: $541
Updated: 2021/12/16

ChemScene

Product number: CS-1152
Product name: CB30865
Purity: 98.05%
Packaging: 5mg
Price: $343
Updated: 2021/12/16

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CB 30865 Chemical Properties,Usage,Production

Uses

CB30865 (ZM 242421) is a nicotinamide phosphoribosyltransferase (Nampt) inhibitor, with potent cytotoxicity. CB30865 is highly potent against a variety of human tumour cell lines (IC50 values in the 1-10 nM range)[1][2]. CB30865 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

References

[1] Fleischer TC, et al. Chemical proteomics identifies Nampt as the target of CB30865, an orphan cytotoxic compound. Chem Biol. 2010 Jun 25;17(6):659-664. DOI:10.1016/j.chembiol.2010.05.008
[2] Skelton LA, et al. Cell cycle effects of CB30865, a lipophilic quinazoline-based analogue of the antifolate thymidylate synthase inhibitor ICI 198583 with an undefined mechanism of action. Cytometry. 1998 Sep 1;33(1):56-66. DOI:10.1002/(sici)1097-0320(19980901)33:13.0.co;2-9

CB 30865 Preparation Products And Raw materials

Raw materials

Preparation Products

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206275-15-2, CB 30865Related Search:

CB 30865

ZM 242421

ZM242421

ZM-242421

4-[[(7-Bromo-1,4-dihydro-2-methyl-4-oxo-6-quinazolinyl)methyl]-2-propynylamino]-N-(3-pyridinylmethyl)benzamide

Benzamide, 4-[[(7-bromo-3,4-dihydro-2-methyl-4-oxo-6-quinazolinyl)methyl]-2-propyn-1-ylamino]-N-(3-pyridinylmethyl)-

4-(((7-bromo-2-methyl-4-oxo-3,4-dihydroquinazolin-6-yl)methyl)(prop-2-yn-1-yl)amino)-n-(pyridin-3-ylmethyl)benzamide

206275-15-2

C26H22BrN5O2