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DG-041

Product Name
DG-041
CAS No.
861238-35-9
Chemical Name
DG-041
Synonyms
DTSI;DG-041;DG-041, 10 mM in DMSO;(E)-3-(1-(2,4-Dichlorobenzyl)-5-fluoro-3-methyl-1H-indol-7-yl)-N-((4,5-dichlorothiophen-2-yl)sulfonyl)acrylamide;(E)-3-[1-[(2,4-dichlorophenyl)methyl]-5-fluoro-3-methylindol-7-yl]-N-(4,5-dichlorothiophen-2-yl)sulfonylprop-2-enamide;(2E)-3-[1-[(2,4-Dichlorophenyl)methyl]-5-fluoro-3-methyl-1H-indol-7-yl]-N-[(4,5-dichloro-2-thienyl)sulfonyl]-2-propenamide;2-Propenamide, 3-[1-[(2,4-dichlorophenyl)methyl]-5-fluoro-3-methyl-1H-indol-7-yl]-N-[(4,5-dichloro-2-thienyl)sulfonyl]-, (2E)-;barrier,DG-041,blood-brain,Inhibitor,DG 041,inhibit,infarction,stroke,plaque,atherothrombosis,atherosclerotic,Prostaglandin Receptor,Myocardial,DG041
CBNumber
CB22627755
Molecular Formula
C23H15Cl4FN2O3S2
Formula Weight
592.32
MOL File
861238-35-9.mol
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DG-041 Property

Melting point:
236-238 °C
Density 
1.57±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
Soluble in DMSO
form 
Solid
pka
3.55±0.10(Predicted)
color 
Light yellow to green yellow
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris
Product number
6240
Product name
DG041
Purity
≥98%(HPLC)
Packaging
10
Price
$193
Updated
2021/12/16
Tocris
Product number
6240
Product name
DG041
Purity
≥98%(HPLC)
Packaging
50
Price
$810
Updated
2021/12/16
TRC
Product number
D299833
Product name
DG041
Packaging
5mg
Price
$340
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0013875
Product name
DG-041
Purity
95.00%
Packaging
5MG
Price
$505.07
Updated
2021/12/16
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DG-041 Chemical Properties,Usage,Production

Uses

DG 041 (cas# 861238-35-9) is a useful research chemical.DG 041 inhibits the EP3 prostanoid receptor. It is being investigated as a potential agent for the treatment of atherothrombosis without inducing unwanted bleeding risk.

in vivo

DG-041 (1.78 mg/kg for intravenous or 9.62 mg/kg for oral) has t1/2 of 2.7 hours, 4.06 hours and Cmax of 9.46 μM, 2.74 μM for intravenous and oral administration, respectively. DG-041 has CL of 1250 mL/h/kg for intravenous[1].

Animal Model:Male SpragueDawley rat[1]
Dosage:1.78 mg/kg (intravenous) or 9.62 mg/kg (oral)
Administration: Intravenous or oral
Result:Had t1/2 of 2.7 hours, 4.06 hours and Cmax of 9.46 μM, 2.74 μM for intravenous and oral administration, respectively.

IC 50

EP3: 4.6-8.1 nM (IC50)

storage

Store at +4°C

DG-041 Preparation Products And Raw materials

Raw materials

Preparation Products

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DG-041 Suppliers

China 25 United Kingdom 1 United States 3 Global 29
Tocris Bioscience
Tel
--
Fax
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Email
customerservice@tocris.co.uk
Country
United Kingdom
ProdList
5726
Advantage
77

861238-35-9, DG-041Related Search:


  • DG-041
  • (E)-3-[1-[(2,4-dichlorophenyl)methyl]-5-fluoro-3-methylindol-7-yl]-N-(4,5-dichlorothiophen-2-yl)sulfonylprop-2-enamide
  • (2E)-3-[1-[(2,4-Dichlorophenyl)methyl]-5-fluoro-3-methyl-1H-indol-7-yl]-N-[(4,5-dichloro-2-thienyl)sulfonyl]-2-propenamide
  • 2-Propenamide, 3-[1-[(2,4-dichlorophenyl)methyl]-5-fluoro-3-methyl-1H-indol-7-yl]-N-[(4,5-dichloro-2-thienyl)sulfonyl]-, (2E)-
  • barrier,DG-041,blood-brain,Inhibitor,DG 041,inhibit,infarction,stroke,plaque,atherothrombosis,atherosclerotic,Prostaglandin Receptor,Myocardial,DG041
  • DTSI
  • (E)-3-(1-(2,4-Dichlorobenzyl)-5-fluoro-3-methyl-1H-indol-7-yl)-N-((4,5-dichlorothiophen-2-yl)sulfonyl)acrylamide
  • DG-041, 10 mM in DMSO
  • 861238-35-9
  • C23H15Cl4FN2O3S2