GGTI-2418

Product Name: GGTI-2418
CAS No.: 501010-06-6
Chemical Name: GGTI-2418
Synonyms: T11396;GGTI-2418;GGTI2418;PTX 100;PTX-100 (GGTI-2418);GGTI 2418 (GGTI2418;(S)-3-benzyl-1-((4-methyl-1-trityl-1H-imidazol-5-yl)methyl)piperazin-2-one;L-Leucine, N-[[(2S)-4-[(5-methyl-1H-imidazol-4-yl)methyl]-3-oxo-2-(phenylmethyl)-1-piperazinyl]carbonyl]-;L-Leucine, N-[[(2S)-4-[(4-methyl-1H-imidazol-5-yl)methyl]-3-oxo-2-(phenylmethyl)-1-piperazinyl]carbonyl]-;(S)-2-((S)-2-Benzyl-4-((5-methyl-1H-imidazol-4-yl)methyl)-3-oxopiperazine-1-carboxamido)-4-methylpentanoic acid
CBNumber: CB22627902
Molecular Formula: C23H31N5O4
Formula Weight: 441.52
MOL File: 501010-06-6.mol

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GGTI-2418 Property

Boiling point:: 807.5±65.0 °C(Predicted)
Density: 1.270±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Store in freezer, under -20°C
solubility: DMSO:125.0(Max Conc. mg/mL);283.11(Max Conc. mM)
form: A crystalline solid
pka: 4.30±0.21(Predicted)
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: G270015
Product name: GGTI2418
Packaging: 1mg
Price: $285
Updated: 2021/12/16

TRC

Product number: G270015
Product name: GGTI2418
Packaging: 2.5mg
Price: $615
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb611301
Product name: GGTI 2418
Purity: >98%
Packaging: 100mg
Price: $1654.1
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb611301
Product name: GGTI 2418
Purity: >98%
Packaging: 250mg
Price: $3136.5
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: INB0009815
Product name: GGTI-2418
Purity: 95.00%
Packaging: 10MG
Price: $4183.99
Updated: 2021/12/16

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GGTI-2418 Chemical Properties,Usage,Production

Uses

GGTI 2418 is a geranylgeranyltransferase I inhibitor.

in vivo

GGTI-2418 (100 mg/kg daily or 200 mg/kg every third day; 15 days) significantly inhibits the growth of breast tumor xenografts in nude mice with MDA-MB-231 xenografts^[1].
GGTI-2418 (100 mg/kg daily; 5 days) induces regression of ErbB2-driven mammary tumors in ErbB2 transgenic mice^[1].
GGTI-2418 inhibits the geranylgeranylation of Rap1 and causes a dramatic decrease in S473 phosphorylation of Akt. GGTI-2418 also upregulates p27 levels in vivo^[1].

Animal Model:	Nude mice implanted with MDA-MB-231 breast cancer tumors^[1]
Dosage:	100 mg/kg daily or 200 mg/kg every third day
Administration:	Injected intraperitoneally; 15 days
Result:	Inhibited the growth of breast tumor xenografts.

Animal Model:	ErbB2 transgenic mice^[1]
Dosage:	100 mg/kg/day
Administration:	Subcutaneously; 5 days
Result:	Halted tumor growth and induced massive tumor regression. Tumor decreased by 76% following GGTI-2418 treatment.

GGTI-2418 Preparation Products And Raw materials

Raw materials

Preparation Products

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GGTI-2418 Suppliers

China 33 United States 6 Global 39

NCE Biomedical Co.,Ltd.

Tel: 4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988
Fax: +86-27-87599188
Country: China
ProdList: 1493
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AdooQ BioScience, LLC

Tel: +1 (866) 930-6790
Fax: +1 (866) 333-9607
Email: info@adooq.com
Country: United States
ProdList: 2782
Advantage: 58

SPIRO PHARMA

Tel
Fax: -
Email: eric_feng1954@126.com
Country: China
ProdList: 316
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Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9803
Advantage: 58

ShangHai Biochempartner Co.,Ltd

Tel: 177-54423994 17754423994
Fax: QQ:2853530913
Email: 2853530910@QQ.com
Country: China
ProdList: 8000
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Shanghai Anyinuo Biomedical Technology Co., Ltd.

Tel: 021-34625901 18018851262;
Email: 420970979@qq.com
Country: China
ProdList: 5894
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TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Country: United States
ProdList: 32435
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Dayang Chem (Hangzhou) Co.,Ltd.

Tel: +86-0571-88938639 +8617705817739
Fax: +86-571-88938652，+86-571- 88492614
Email: info@dycnchem.com
Country: China
ProdList: 52846
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Career Henan Chemica Co

Tel: +86-0371-86658258 +8613203830695
Fax: 0371-86658258
Email: laboratory@coreychem.com
Country: China
ProdList: 30229
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BOC Sciences

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Fax: 1-631-614-7828
Email: inquiry@bocsci.com
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501010-06-6, GGTI-2418Related Search:

GGTI-2418

(S)-3-benzyl-1-((4-methyl-1-trityl-1H-imidazol-5-yl)methyl)piperazin-2-one

GGTI2418;PTX 100

GGTI 2418 (GGTI2418

L-Leucine, N-[[(2S)-4-[(4-methyl-1H-imidazol-5-yl)methyl]-3-oxo-2-(phenylmethyl)-1-piperazinyl]carbonyl]-

L-Leucine, N-[[(2S)-4-[(5-methyl-1H-imidazol-4-yl)methyl]-3-oxo-2-(phenylmethyl)-1-piperazinyl]carbonyl]-

(S)-2-((S)-2-Benzyl-4-((5-methyl-1H-imidazol-4-yl)methyl)-3-oxopiperazine-1-carboxamido)-4-methylpentanoic acid

PTX-100 (GGTI-2418)

T11396

501010-06-6