BAX INHIBITOR PEPTIDE P5
- Product Name
- BAX INHIBITOR PEPTIDE P5
- CAS No.
- 579492-83-4
- Chemical Name
- BAX INHIBITOR PEPTIDE P5
- Synonyms
- BAX INHIBITOR PEPTIDE P5;L-Glutamic acid, L-prolyl-L-methionyl-L-leucyl-L-lysyl-
- CBNumber
- CB2262796
- Molecular Formula
- C27H48N6O8S
- Formula Weight
- 616.77
- MOL File
- 579492-83-4.mol
BAX INHIBITOR PEPTIDE P5 Property
- Boiling point:
- 1001.4±65.0 °C(Predicted)
- Density
- 1.238±0.06 g/cm3(Predicted)
- storage temp.
- Desiccate at -20°C
- solubility
- ≥61.7 mg/mL in DMSO; ≥101 mg/mL in EtOH with ultrasonic; ≥94.4 mg/mL in H2O
- form
- solid
- pka
- 3.16±0.10(Predicted)
N-Bromosuccinimide Price
- Product number
- A4460
- Product name
- BaxinhibitorpeptideP5
- Packaging
- 5mg
- Price
- $120
- Updated
- 2021/12/16
- Product number
- A4460
- Product name
- BaxinhibitorpeptideP5
- Packaging
- 10mg
- Price
- $180
- Updated
- 2021/12/16
- Product number
- A4460
- Product name
- BaxinhibitorpeptideP5
- Packaging
- 100mg
- Price
- $1080
- Updated
- 2021/12/16
BAX INHIBITOR PEPTIDE P5 Chemical Properties,Usage,Production
Uses
Bax Inhibitor Peptide P5 is a cell-permeable pentapeptide based on the Ku70-Bax inhibiting domain. Acts as an effective Inhibitor for Bax-mediated apoptosis (~50-200 uM).
Biological Activity
bax inhibitor peptide p5 (bip p5) is a peptide inhibitor of bax translocation to mitochondria [1].bax is a pro-apoptotic member of bcl-2 family proteins and plays an important role in mitochondria-dependent apoptosis. bax stays in the cytosol and transfers into mitochondria after apoptotic stimuli [1].bip p5 is a membrane-permeable peptide inhibitor of bax translocation to mitochondria. in hela cells, bip p5 protected cells from uvc- and sts-induced apoptosis. in u87-mg glioma cells, mcf-7 breast cancer cells and lncap prostate cancer cells, bip p5 also inhibited apoptosis induced by anti-cancer drugs cisplatin, etoposide and doxorubicin. while bip p5 did not suppress uvc- or sts-induced apoptosis in bax-deficient cells (du145), which suggested bip p5 only suppressed bax-mediated apoptosis. the caspase activation and the release of cytochrome c from mitochondria triggered by apoptotic stimuli were also significantly inhibited by bip p5. bip p5 inhibited the interaction of ku70 and endogenous bax in a dose-dependent way [1].
References
[1]. sawada m, hayes p, matsuyama s. cytoprotective membrane-permeable peptides designed from the bax-binding domain of ku70. nat cell biol, 2003, 5(4): 352-357.
BAX INHIBITOR PEPTIDE P5 Preparation Products And Raw materials
Raw materials
Preparation Products
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