NMS-P715

Product Name: NMS-P715
CAS No.: 1202055-34-2
Chemical Name: NMS-P715
Synonyms: CS-1822;NMS-P715;NMS P715 analog;NMS-P715 analog;NMS-P 715 analog;NMS P715 ANALOG;NMS-P 715 ANALOG;1H-Pyrazolo[4,3-h]quinazoline-3-carboxamide, N-(2,6-diethylphenyl)-4,5-dihydro-8-[[2-methoxy-4-[[(1-methyl-4-piperidinyl)amino]carbonyl]phenyl]amino]-1-methyl-;N-(2,6-diethylphenyl)-1-Methyl-8-({4-[(1-Methylpiperidin-4-yl)carbaMoyl]-2-(trifluoroMethoxy)phenyl}aMino)-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxaMide;N-(2,6-diethylphenyl)-1-methyl-8-((4-((1-methylpiperidin-4-yl)carbamoyl)-2-(trifluoromethoxy)phenyl)amino)-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide NMS-P715
CBNumber: CB22628196
Molecular Formula: C35H42N8O3
Formula Weight: 622.76
MOL File: 1202055-34-2.mol

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NMS-P715 Property

Density: 1.32±0.1 g/cm3(Predicted)
storage temp.: -70°C
solubility: Soluble in DMSO
form: Powder
pka: 11.75±0.70(Predicted)

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Safety

WGK Germany: WGK 1
Storage Class: 10 - Combustible liquids

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: API0014037
Product name: NMS-P715
Purity: 95.00%
Packaging: 5MG
Price: $358.6
Updated: 2021/12/16

Crysdot

Product number: CD31004311
Product name: NMS-P715analog
Purity: 98+%
Packaging: 5mg
Price: $111
Updated: 2021/12/16

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NMS-P715 Chemical Properties,Usage,Production

Uses

An orally bioavailable, ATP-competitive, pyrazolo-quinazoline, MPS1 inhibitor (IC₅₀ = 182 nM, K_i = 0.99 nM) that is shown to act in a reversible and time-dependent manner. It demonstrates selectivity for MPS1 against a panel of 60 kinases, displaying activity against only three kinases, CK2, MELK, and NEK6 (<10 µM), but not against other mitotic kinases including PLK1, CDK1, Aurora A, Aurora B, or the SAC kinase BUB1, in an in vitro kinase assay. It promotes massive SAC (spindle assembly checkpoint) override (EC₅₀ = 65 nM) in nocodazole-arrested U20S cells and elicits a reduction in the G1 and G2/M phase of the cell cycle in A2780 ovarian cancer cells, similar to RNAi-mediated MPS1 silencing. In addition, it is shown to inactivate SAC, delocalize kinetochore components, and inhibit the proliferation of select cancer cell lines (IC₅₀ ~ 1 µM), without marked activity among a panel of 127 normal cell lines. Also, it inhibits A2780 tumor xenograft growth in mice (90 mg/kg/day, o.s., in vivo) by 53% without marked body weight loss.

Biological Activity

Cell permeable: yes', 'Primary Target
MPS1', 'Reversible: yes

NMS-P715 Preparation Products And Raw materials

Raw materials

Preparation Products

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NMS-P715 Suppliers

CHINA 31 United States 2 Global 33

LETOPHARM LIMITED

Tel: +86-21-5821 5861
Fax: +86-21-5106 2861
Email: sales@letopharm.com
Country: China
ProdList: 2384
Advantage: 58

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4827
Advantage: 55

AN PharmaTech Co Ltd

Tel: 86(21)68097365
Fax: 86(21)33321566
Email: sales@anpharma.net
Country: China
ProdList: 4891
Advantage: 55

Struchem Co., Ltd.

Tel: 0512-63009836 18994340901
Fax: 0512-63006936
Email: helen@struchem.com
Country: China
ProdList: 3979
Advantage: 60

Medi-tech Bioscientific Co., Ltd.

Tel: 0519-83246372 13585352506
Fax: 0519-83246372
Country: China
ProdList: 1844
Advantage: 58

Musechem

Tel: +1-800-259-7612
Fax: +1-800-259-7612
Email: info@musechem.com
Country: United States
ProdList: 4660
Advantage: 60

Career Henan Chemica Co

Tel: +86-0371-86658258 +8613203830695
Fax: 0371-86658258
Email: laboratory@coreychem.com
Country: China
ProdList: 30227
Advantage: 58

Cckinase, Inc.

Tel: +1 (732)236-3202
Email: sales@cckinase.com
Country: United States
ProdList: 2738
Advantage: 58

Beijing xinyanhui pharmaceutical research and development co., LTD

Tel: 13969155946
Email: 1461866103@qq.com
Country: China
ProdList: 16111
Advantage: 58

Shanghai Zeye Biotechnology Co., Ltd.

Tel: 021-57896695 13122364865
Email: sale1@shzysw.net
Country: China
ProdList: 9779
Advantage: 58

1202055-34-2, NMS-P715Related Search:

5-[2,4-Dihydroxy-6-(4-nitrophenoxy)phenyl]-N-(1-methyl-4-piperidinyl)-3-isoxazolecarboxamide

NMS-P715

N-(2,6-diethylphenyl)-1-Methyl-8-({4-[(1-Methylpiperidin-4-yl)carbaMoyl]-2-(trifluoroMethoxy)phenyl}aMino)-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxaMide

NMS P715 analog

NMS-P 715 analog

NMS-P715 analog

N-(2,6-diethylphenyl)-1-methyl-8-((4-((1-methylpiperidin-4-yl)carbamoyl)-2-(trifluoromethoxy)phenyl)amino)-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide NMS-P715

CS-1822

NMS P715 ANALOG;NMS-P 715 ANALOG

1H-Pyrazolo[4,3-h]quinazoline-3-carboxamide, N-(2,6-diethylphenyl)-4,5-dihydro-8-[[2-methoxy-4-[[(1-methyl-4-piperidinyl)amino]carbonyl]phenyl]amino]-1-methyl-

1202055-34-2

C35H42N8O3