Pyrido[2,3-d]pyriMidin-7(8H)-one, 6-(2,4-difluorophenoxy)-8-Methyl-2-[(tetrahydro-2H-pyran-4-yl)aMino]-

Product Name: Pyrido[2,3-d]pyriMidin-7(8H)-one, 6-(2,4-difluorophenoxy)-8-Methyl-2-[(tetrahydro-2H-pyran-4-yl)aMino]-
CAS No.: 449811-92-1
Chemical Name: Pyrido[2,3-d]pyriMidin-7(8H)-one, 6-(2,4-difluorophenoxy)-8-Methyl-2-[(tetrahydro-2H-pyran-4-yl)aMino]-
Synonyms: [14C]-R1487;R1487 free base;6-(2,4-difluorophenoxy)-8-methyl-2-[(oxan-4-yl)amino]-7H,8H-pyrido[2,3-d]pyrimidin-7-one;6-(2,4-Difluorophenoxy)-8-methyl-2-((tetrahydro-2H-pyran-4-yl)amino)pyrido[2,3-d]pyrimidin-7(8;6-(2,4-Difluorophenoxy)-8-methyl-2-[(tetrahydro-2H-pyran-4-yl)amino]-pyrido[2,3-d]pyrimidin-7(8H)-one;Pyrido[2,3-d]pyriMidin-7(8H)-one, 6-(2,4-difluorophenoxy)-8-Methyl-2-[(tetrahydro-2H-pyran-4-yl)aMino]-
CBNumber: CB22628318
Molecular Formula: C19H18F2N4O3
Formula Weight: 388.37
MOL File: 449811-92-1.mol

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Pyrido[2,3-d]pyriMidin-7(8H)-one, 6-(2,4-difluorophenoxy)-8-Methyl-2-[(tetrahydro-2H-pyran-4-yl)aMino]- Property

Melting point:: 185.7-187.5 °C
Boiling point:: 548.9±60.0 °C(Predicted)
Density: 1.425±0.06 g/cm3(Predicted)
pka: 3.55±0.20(Predicted)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: HCH0316557
Product name: 6-(2,4-DIFLUOROPHENOXY)-8-METHYL-2-[(TETRAHYDRO-2H-PYRAN-4-YL)AMINO]-PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE
Purity: 95.00%
Packaging: 5MG
Price: $502.39
Updated: 2021/12/16

Matrix Scientific

Product number: 132626
Product name: 6-(2,4-Difluorophenoxy)-8-methyl-2-((tetrahydro-2H-pyran-4-yl)amino)pyrido[2,3-d]pyrimidin-7(8H)-one
Purity: 97%
Packaging: 500mg
Price: $2850
Updated: 2021/12/16

Matrix Scientific

Product number: 132626
Product name: 6-(2,4-Difluorophenoxy)-8-methyl-2-((tetrahydro-2H-pyran-4-yl)amino)pyrido[2,3-d]pyrimidin-7(8H)-one
Purity: 97%
Packaging: 5g
Price: $7740
Updated: 2021/12/16

Matrix Scientific

Product number: 132626
Product name: 6-(2,4-Difluorophenoxy)-8-methyl-2-((tetrahydro-2H-pyran-4-yl)amino)pyrido[2,3-d]pyrimidin-7(8H)-one
Purity: 97%
Packaging: 10g
Price: $12420
Updated: 2021/12/16

DC Chemicals

Product number: DC10053
Product name: R1487
Purity: >98%
Packaging: 100mg
Price: $450
Updated: 2021/12/16

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Pyrido[2,3-d]pyriMidin-7(8H)-one, 6-(2,4-difluorophenoxy)-8-Methyl-2-[(tetrahydro-2H-pyran-4-yl)aMino]- Chemical Properties,Usage,Production

Uses

R 1487 is an orally active and highly selective p38α mitogen-activated protein kinase inhibitor. R 1487 can be used in the study of rheumatoid arthritis[1].

References

[1] Goldstein DM, et al. Discovery of 6-(2,4-difluorophenoxy)-2-[3-hydroxy-1-(2-hydroxyethyl)propylamino]-8-methyl-8H-pyrido[2,3-d]pyrimidin-7-one (pamapimod) and 6-(2,4-difluorophenoxy)-8-methyl-2-(tetrahydro-2H-pyran-4-ylamino)pyrido[2,3-d]pyrimidin-7(8H)-one (R1487) as orally bioavailable and highly selective inhibitors of p38α mitogen-activated protein kinase. J Med Chem. 2011 Apr 14;54(7):2255-65. DOI:10.1021/jm101423y

Pyrido[2,3-d]pyriMidin-7(8H)-one, 6-(2,4-difluorophenoxy)-8-Methyl-2-[(tetrahydro-2H-pyran-4-yl)aMino]- Preparation Products And Raw materials

Raw materials

Preparation Products

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Pyrido[2,3-d]pyriMidin-7(8H)-one, 6-(2,4-difluorophenoxy)-8-Methyl-2-[(tetrahydro-2H-pyran-4-yl)aMino]- Suppliers

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449811-92-1, Pyrido[2,3-d]pyriMidin-7(8H)-one, 6-(2,4-difluorophenoxy)-8-Methyl-2-[(tetrahydro-2H-pyran-4-yl)aMino]-Related Search:

6-(2,4-Difluorophenoxy)-8-Methyl-2-(Methylthio)pyrido[2,3-d]pyriMidin-7(8H)-one

Pyrido[2,3-d]pyriMidin-7(8H)-one, 6-(2,4-difluorophenoxy)-8-Methyl-2-[(tetrahydro-2H-pyran-4-yl)aMino]-

6-(2,4-Difluorophenoxy)-8-methyl-2-[(tetrahydro-2H-pyran-4-yl)amino]-pyrido[2,3-d]pyrimidin-7(8H)-one

R1487 free base

6-(2,4-Difluorophenoxy)-8-methyl-2-((tetrahydro-2H-pyran-4-yl)amino)pyrido[2,3-d]pyrimidin-7(8

[14C]-R1487

6-(2,4-difluorophenoxy)-8-methyl-2-[(oxan-4-yl)amino]-7H,8H-pyrido[2,3-d]pyrimidin-7-one

449811-92-1