QRX 431

Product Name: QRX 431
CAS No.: 211110-63-3
Chemical Name: QRX 431
Synonyms: GC-1;EIEE3;NET44;QRX 431;Anti-GC1;Anti-OlfD;SobetiroMe;Anti-GW112;Anti-NET44;GC-1; QRX-431
CBNumber: CB22628338
Molecular Formula: C20H24O4
Formula Weight: 328.4
MOL File: 211110-63-3.mol

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QRX 431 Property

Melting point:: 122 - 124°C
Boiling point:: 510.2±45.0 °C(Predicted)
Density: 1.152±0.06 g/cm3(Predicted)
storage temp.: -20°C
solubility: DMSO: soluble10mg/mL, clear
pka: 3.22±0.10(Predicted)
form: powder
color: white to beige
InChIKey: QNAZTOHXCZPOSA-UHFFFAOYSA-N

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1900
Product name: Sobetirome
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $105
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML1900
Product name: Sobetirome
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $169.6
Updated: 2024/03/01

Sigma-Aldrich

Product number: AV44041
Product name: Anti-SLC25A22 antibody produced in rabbit
Purity: IgG fraction of antiserum
Packaging: 100μL
Price: $443
Updated: 2024/03/01

Tocris

Product number: 4554
Product name: GC1
Purity: ≥98%(HPLC)
Packaging: 10
Price: $196
Updated: 2021/12/16

Usbiological

Product number: 255368
Product name: GC 1
Packaging: 10mg
Price: $446
Updated: 2021/12/16

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QRX 431 Chemical Properties,Usage,Production

Uses

GC 1 is a high affinity thyroid receptor α (TRα) and TRβ agonist.

Definition

ChEBI: Sobetirome is a diarylmethane.

Biological Activity

sobetirome (3,5-dimethyl-4[(4'-hydroxy-3'-isopropylbenzyl)-phenoxy] acetic acid, also known as gc-1 and qrx-431, is a member of a class of compounds known as selective thyromimetics.it was firstly developed by thomas scanlan’s group at the university of california-san francisco (ucsf) in 1995 1.in cholesterol-fed rats, sobetirome was shown to lower plasma cholesterol in a dose-dependent manner by up to 75% of untreated controls. in hypercholesterolemic mice, sobetirome was failed to induce ldl receptor mrna expression. in different mouse models, sobetirome and t-0681 were shown to promote bile acid production and biliary sterol secretion. in cynomolgus monkeys, sobetirome was shown to reduce plasma cholesterol in a dose-dependent manner by up to 30%. both sobetirome and t-0681 were shown to increase hepatic expression of the hdl receptor (scavenger receptor-bi, sr-bi) in animals.in phase i

Biochem/physiol Actions

Sobetirome is also termed as 2-(4-(4-(benzyloxy)-3-isopropylbenzyl)-3,5-dimethylphenoxy)acetic acid/ GC-1. It has an inner-ring and negatively charged carboxylate groups at physiological pH. Sobetirome is considered as a cholesterol lowering agent in humans.

storage

Store at -20°C

References

1. tancevski i, demetz e, eller p. sobetirome: a selective thyromimetic for the treatment of dyslipidemia. recent pat cardiovasc drug discov. 2011 jan;6(1):16-9.

QRX 431 Preparation Products And Raw materials

Raw materials

Preparation Products

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QRX 431 Suppliers

China 71 United Kingdom 1 United States 12 Global 84

Cochemical Ltd.

Tel: 029-86115547 17791676824
Fax: 02151602123
Email: sales@cochemical.com
Country: China
ProdList: 3049
Advantage: 58

Haoyuan Chemexpress Co., Ltd.

Tel: 021-58950125
Fax: (86) 21-58955996
Email: info@chemexpress.com
Country: China
ProdList: 7553
Advantage: 61

MedChemexpress LLC

Tel: 021-58955995
Fax: 609-228-5909
Email: sales@medchemexpress.cn
Country: United States
ProdList: 4863
Advantage: 58

LETOPHARM LIMITED

Tel: +86-21-5821 5861
Fax: +86-21-5106 2861
Email: sales@letopharm.com
Country: China
ProdList: 2384
Advantage: 58

Sigma-Aldrich

Tel: 021-61415566 800-8193336
Email: orderCN@merckgroup.com
Country: China
ProdList: 51471
Advantage: 80

SPIRO PHARMA

Tel
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Country: China
ProdList: 9254
Advantage: 55

EMMX Biotechnology LLC

Tel: 888-539-0666
Fax: 888-539-0666
Email: info@emmx.com
Country: United States
ProdList: 8449
Advantage: 60

Guangzhou QiYun Biotechnology Co., Ltd.

Tel: 020-61288194 61288195
Fax: 020-61288700
Email: 505721671@qq.com
Country: China
ProdList: 3868
Advantage: 58

Shanghai Chaolan Chemical Technology Center

Tel: QQ:65489617 15618227136
Fax: 21-5161 9052
Email: info@SuperLan-chem.com
Country: China
ProdList: 9445
Advantage: 58

Shanghai SuperLan Chemcial Technique Centre

Tel: 021-2022843681 15618226720
Fax: +86-21-51601218
Email: chaolaichem@foxmail.com
Country: China
ProdList: 7565
Advantage: 58

211110-63-3, QRX 431Related Search:

GC-1; QRX-431

2-[4-[[4-Hydroxy-3-(1-methylethyl)phenyl]methyl]-3,5-dimethylphenoxy]acetic acid

GC-1 (Sobetirome)

Anti-solute carrier family 25 (mitochondrial carrier: glutamate), member 22

[4-(4-Hydroxy-3-isopropyl-benzyl)-3,5-dimethyl-phenoxy]-acetic acid

QRX 431

GC-1

SobetiroMe

[3,5-Dimethyl-4-(4-hydroxy-3-isopropylbenzyl)phenoxy]acetic acid

GC 1 (pharmaceutical)

2-(4-(4-Hydroxy-3-isopropylbenzyl)-3,5-dimethylphenoxy)acetic acid

Anti-SLC25A22 antibody produced in rabbit

EIEE3

NET44

Anti-SLC25A22, (N-terminal) antibody produced in rabbit

Anti-bA209J19.1

Anti-GW112

Anti-KIAA4294

Anti-Olfactomedin 4

Anti-OlfD

Anti-FLJ13044

Anti-GC1

Anti-NET44

Acetic acid, 2-[4-[[4-hydroxy-3-(1-methylethyl)phenyl]methyl]-3,5-dimethylphenoxy]-

Sobetirome >=98% (HPLC)

QRX431,Inhibitor,GC1,Sobetirome,inhibit,QRX 431,Thyroid Hormone Receptor,GC-1,GC 1,THR

211110-63-3