5-cyclopropylpyridin-3-aMine
- Product Name
- 5-cyclopropylpyridin-3-aMine
- CAS No.
- 1314353-68-8
- Chemical Name
- 5-cyclopropylpyridin-3-aMine
- Synonyms
- 5-cyclopropylpyridin-3-aMine;3-Amino-5-cyclopropylpyridine;3-Pyridinamine, 5-cyclopropyl-
- CBNumber
- CB22631332
- Molecular Formula
- C8H10N2
- Formula Weight
- 134.18
- MOL File
- 1314353-68-8.mol
5-cyclopropylpyridin-3-aMine Property
- Boiling point:
- 308.6±30.0 °C(Predicted)
- Density
- 1.188±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- pka
- 6.54±0.20(Predicted)
- Appearance
- Light yellow to yellow Solid
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- OR42287
- Product name
- 3-Amino-5-cyclopropylpyridine
- Packaging
- 250mg
- Price
- $143
- Updated
- 2021/12/16
- Product number
- 3H30-1-UF
- Product name
- 3-Amino-5-cyclopropylpyridine
- Packaging
- 250mg
- Price
- $157
- Updated
- 2021/12/16
- Product number
- OR42287
- Product name
- 3-Amino-5-cyclopropylpyridine
- Packaging
- 1g
- Price
- $377
- Updated
- 2021/12/16
- Product number
- 3H30-1-UF
- Product name
- 3-Amino-5-cyclopropylpyridine
- Packaging
- 1g
- Price
- $416
- Updated
- 2021/12/16
- Product number
- CHM0390697
- Product name
- 5-CYCLOPROPYLPYRIDIN-3-AMINE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $502.6
- Updated
- 2021/12/16
5-cyclopropylpyridin-3-aMine Chemical Properties,Usage,Production
Synthesis
13535-01-8
411235-57-9
1314353-68-8
General procedure for the synthesis of 5-cyclopropylpyridin-3-amine from 5-bromo-3-aminopyridine and cyclopropylboronic acid: To a solution of 5-bromopyridin-3-amine (4.75 g, 27.45 mmol) in dioxane (45 mL) was added cyclopropylboronic acid (4.75 g, 55.30 mmol), cesium carbonate (Cs2CO3, 28 g, 85.67 mmol) in sequence , tetrakis(triphenylphosphine)palladium (1.66 g, 1.44 mmol), and water (5 mL), and mixed with stirring at room temperature. The reaction mixture was heated to 100 °C with continuous stirring for 15 hours. After the reaction was completed, it was cooled to room temperature and the reaction mixture was diluted with water (200 mL). The mixture was extracted with ethyl acetate (500 mL x 3) and the organic phases were combined. The organic phase was washed with saturated brine and dried over anhydrous sodium sulfate (Na2SO4). The solvent was removed by concentration under reduced pressure and the residue was purified by fast column chromatography using hexane/ethyl acetate (0% to 100% gradient) as eluent to afford 5-cyclopropylpyridin-3-amine as a light brown oil (2.08 g, 56% yield). Mass spectrum (MS): m/z = 135.0 [M + H]+.
References
[1] Patent: WO2017/106607, 2017, A1. Location in patent: Paragraph 00477
[2] Patent: EP2762476, 2014, A1. Location in patent: Paragraph 0174
[3] Patent: US2014/309225, 2014, A1. Location in patent: Paragraph 0700; 0701; 0702; 0703
5-cyclopropylpyridin-3-aMine Preparation Products And Raw materials
Raw materials
Preparation Products
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