ChemicalBook > CAS DataBase List > 6-tert-butyl-2-(furan-2-carboxaMido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid

6-tert-butyl-2-(furan-2-carboxaMido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid

Product Name
6-tert-butyl-2-(furan-2-carboxaMido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid
CAS No.
407587-33-1
Chemical Name
6-tert-butyl-2-(furan-2-carboxaMido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid
Synonyms
CaCCinh-A01;TMEM16 BLOCKER I;CaCCinh-A01 ，S0125;CaCCinh-A01, 10 mM in DMSO;CaCC(inh)-A01, TMEM16 Blocker I.;CACCINH-A01; CACC(INH)-A01, TMEM16 BLOCKER I.;6-tert-butyl-2-(furan-2-carboxaMido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid;6-(1,1-Dimethylethyl)-2-[(2-furanylcarbonyl)amino]-4,5,6,7-tetrahydro-benzo[b]thiophene-3-carboxylic acid;Benzo[b]thiophene-3-carboxylic acid, 6-(1,1-dimethylethyl)-2-[(2-furanylcarbonyl)amino]-4,5,6,7-tetrahydro-
CBNumber
CB22631367
Molecular Formula
C18H21NO4S
Formula Weight
347.43
MOL File
407587-33-1.mol
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6-tert-butyl-2-(furan-2-carboxaMido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid Property

Boiling point:
429.7±45.0 °C(Predicted)
Density 
1.305±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO: soluble20mg/mL, clear
form 
powder
pka
4.49±0.40(Predicted)
color 
white to beige
InChI
1S/C18H21NO4S/c1-18(2,3)10-6-7-11-13(9-10)24-16(14(11)17(21)22)19-15(20)12-5-4-8-23-12/h4-5,8,10H,6-7,9H2,1-3H3,(H,19,20)(H,21,22)
InChIKey
ACLUEOBQFRYTQS-UHFFFAOYSA-N
SMILES
[s]1c2c(c(c1NC(=O)c3[o]ccc3)C(=O)O)CCC(C2)C(C)(C)C
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Safety

WGK Germany 
3
Storage Class
11 - Combustible Solids
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML0916
Product name
CaCCinh-A01
Purity
≥98% (HPLC)
Packaging
5mg
Price
$114.95
Updated
2025/07/31
Sigma-Aldrich
Product number
SML0916
Product name
CaCCinh-A01
Purity
≥98% (HPLC)
Packaging
25mg
Price
$491
Updated
2025/07/31
Sigma-Aldrich
Product number
208293
Product name
Calcium-activated Chloride Channel Inhibitor, CaCCinh-A01
Purity
The Calcium-activated Chloride Channel Inhibitor, CaCCinh-A01 controls the biological activity of Calcium-activated Chloride Channel.
Packaging
10 mg
Price
$189
Updated
2025/07/31
Sigma-Aldrich
Product number
5.08628
Product name
InSolution Calcium-activated Chloride Channel Inhibitor, CaCCinh-A01 - CAS 407587-33-1 - Calbiochem
Packaging
5mg
Price
$129
Updated
2022/05/15
Cayman Chemical
Product number
21922
Product name
CaCC(inh)-A01
Purity
≥98%
Packaging
5mg
Price
$67
Updated
2024/03/01
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6-tert-butyl-2-(furan-2-carboxaMido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid Chemical Properties,Usage,Production

Uses

CaCC(inh)-A01 is a potent, selective class A inhibitor of calcium-activated chloride channels (CaCCs).

Biochem/physiol Actions

CaCCinh-A01 is a TMEM16A (transmembrane member 16A) inhibitor. It also blocks anoctamin-1 (ANO1) and decreases cell viability and represses cell migration.

in vivo

CaCCinh-A01 (vein injection; 5 mg/kg; caudal vein injection within 15 min after the onset of reperfusion) significantly reduces infarction when compared with MCAO-saline treatment at 24 h or 72 h in middle cerebral artery occlusion model in mice[3].

Animal Model:Two-month-old male C57/BL6J mice[3]
Dosage:5 mg/kg
Administration:Vein injection; 5 mg/kg; caudal vein injection within 15 min after the onset of reperfusion
Result:Attenuated brain infarct size, improved neurological outcomes and lowered BBB permeability after ischemic stroke in mice.

storage

Store at -20°C

6-tert-butyl-2-(furan-2-carboxaMido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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6-tert-butyl-2-(furan-2-carboxaMido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid Suppliers

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View Lastest Price from 6-tert-butyl-2-(furan-2-carboxaMido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid manufacturers

Career Henan Chemical Co
Product
6-tert-butyl-2-(furan-2-carboxaMido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid 407587-33-1
Price
US $9.80/KG
Min. Order
1g
Purity
≥99%
Supply Ability
100kg
Release date
2020-01-12

407587-33-1, 6-tert-butyl-2-(furan-2-carboxaMido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acidRelated Search:


  • 6-tert-butyl-2-(furan-2-carboxaMido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid
  • CaCCinh-A01
  • 6-(1,1-Dimethylethyl)-2-[(2-furanylcarbonyl)amino]-4,5,6,7-tetrahydro-benzo[b]thiophene-3-carboxylic acid
  • TMEM16 BLOCKER I
  • CaCC(inh)-A01, TMEM16 Blocker I.
  • CACCINH-A01; CACC(INH)-A01, TMEM16 BLOCKER I.
  • Benzo[b]thiophene-3-carboxylic acid, 6-(1,1-dimethylethyl)-2-[(2-furanylcarbonyl)amino]-4,5,6,7-tetrahydro-
  • CaCCinh-A01, 10 mM in DMSO
  • CaCCinh-A01 ，S0125
  • 407587-33-1