(4-Chloro-2-nitro-phenyl)-Methyl-aMine
- Product Name
- (4-Chloro-2-nitro-phenyl)-Methyl-aMine
- CAS No.
- 15950-17-1
- Chemical Name
- (4-Chloro-2-nitro-phenyl)-Methyl-aMine
- Synonyms
- 4-chloro-N-methyl-2-nitrobenzenamine;(4-Chloro-2-nitro-phenyl)-Methyl-aMine;Benzenamine, 4-chloro-N-methyl-2-nitro-
- CBNumber
- CB22638331
- Molecular Formula
- C7H7ClN2O2
- Formula Weight
- 186.6
- MOL File
- 15950-17-1.mol
(4-Chloro-2-nitro-phenyl)-Methyl-aMine Property
- Melting point:
- 108-109 °C
- Boiling point:
- 317.7±27.0 °C(Predicted)
- Density
- 1.406±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
- pka
- -1.68±0.25(Predicted)
- Appearance
- Yellow to orange Solid
Safety
- HS Code
- 2921420090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C428328
- Product name
- 4-Chloro-N-methyl-2-nitroaniline
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- FC141101
- Product name
- 4-Chloro-N-methyl-2-nitroaniline
- Packaging
- 100mg
- Price
- $51
- Updated
- 2021/12/16
- Product number
- FC141101
- Product name
- 4-Chloro-N-methyl-2-nitroaniline
- Packaging
- 250mg
- Price
- $100
- Updated
- 2021/12/16
- Product number
- CS-D0533
- Product name
- 4-Chloro-N-methyl-2-nitroaniline
- Packaging
- 5g
- Price
- $435
- Updated
- 2021/12/16
- Product number
- CS-D0533
- Product name
- 4-Chloro-N-methyl-2-nitroaniline
- Packaging
- 1g
- Price
- $158
- Updated
- 2021/12/16
(4-Chloro-2-nitro-phenyl)-Methyl-aMine Chemical Properties,Usage,Production
Uses
4-Chloro-N-methyl-2-nitroaniline is used for catalytic hydrogenation to synthesize 2-(trifluoromethyl)benzimidazole derivatives.
Synthesis
74-89-5
89-61-2
15950-17-1
General procedure for the synthesis of 4-chloro-N-methyl-2-nitroaniline from 1,4-dichloro-2-nitrobenzene and 30% methanamidol solution: 1,4-dichloro-2-nitrobenzene (5 g, 26 mmol) was dissolved in 30% methanamidol solution (50 mL), and the reaction was stirred for 4 hours at 50 °C. Upon completion of the reaction, the reaction mixture was quenched with water (50 mL) and subsequently extracted with ethyl acetate (80 mL x 3). The organic layers were combined, washed with brine (150 mL × 2), dried over anhydrous sodium sulfate, and concentrated under reduced pressure to afford the target product 4-chloro-N-methyl-2-nitroaniline (4 g, 84% yield) as a red solid. The product was characterized by LC-MS and 1H-NMR: LC-MS (m/z): 187 [M + 1]+; 1H-NMR (CDCl3, 400MHz) main characteristic peaks: δ (ppm) 2.95 (d, J = 4.8 Hz, 3H), 7.04 (d, J = 9.2 Hz, 1H), 7.59 (d, J = 9.2 Hz, 1H) 8.05 (s, 1H), 8.24 (s, 1H).
References
[1] Patent: WO2015/42397, 2015, A1. Location in patent: Paragraph 000314
[2] Journal of the Chemical Society, 1949, p. 2579,2581
[3] Recueil des Travaux Chimiques des Pays-Bas, 1902, vol. 21, p. 258
[4] Recueil des Travaux Chimiques des Pays-Bas, 1908, vol. 27, p. 35 Anm. 2
[5] Russian Journal of Organic Chemistry, 2004, vol. 40, # 10, p. 1473 - 1476
(4-Chloro-2-nitro-phenyl)-Methyl-aMine Preparation Products And Raw materials
Raw materials
Preparation Products
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