4-Piperidinone, 1-(4-nitrophenyl)-

Product Name: 4-Piperidinone, 1-(4-nitrophenyl)-
CAS No.: 23499-01-6
Chemical Name: 4-Piperidinone, 1-(4-nitrophenyl)-
Synonyms: 1-(4-nitrophenyl)-4-piperidinone;1-(4-NITROPHENYL)PIPERIDINE-4-ONE;4-Piperidinone, 1-(4-nitrophenyl)-;2(3H)-Benzoxazolone,6-bromo-6-(triphenylmethyl)-
CBNumber: CB22639338
Molecular Formula: C11H12N2O3
Formula Weight: 220.22
MOL File: 23499-01-6.mol

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4-Piperidinone, 1-(4-nitrophenyl)- Property

Melting point:: 167.0-167.5 °C
Boiling point:: 422.7±40.0 °C(Predicted)
Density: 1.295±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
pka: 0.81±0.40(Predicted)
Appearance: Light yellow to yellow Solid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: N926558
Product name: 1-(4-Nitrophenyl)piperidin-4-one
Packaging: 50mg
Price: $65
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0126815
Product name: 1-(4-NITROPHENYL)TETRAHYDRO-4(1H)-PYRIDINONE
Purity: 95.00%
Packaging: 1G
Price: $808.89
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0126815
Product name: 1-(4-NITROPHENYL)TETRAHYDRO-4(1H)-PYRIDINONE
Purity: 95.00%
Packaging: 2.5G
Price: $1147.43
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0126815
Product name: 1-(4-NITROPHENYL)TETRAHYDRO-4(1H)-PYRIDINONE
Purity: 95.00%
Packaging: 5G
Price: $1421.65
Updated: 2021/12/16

AK Scientific

Product number: 1444AL
Product name: 1-(4-Nitrophenyl)piperidin-4-one
Packaging: 1g
Price: $143
Updated: 2021/12/16

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4-Piperidinone, 1-(4-nitrophenyl)- Chemical Properties,Usage,Production

Synthesis

350-46-9

23499-01-6

General procedure for the synthesis of 1-(4-nitrophenyl)-piperidin-4-one from p-fluoronitrobenzene: To acetonitrile (20 mL) were added 4-piperidinone hydrochloride (2.17 g, 16.0 mmol), triethylamine (3.9 mL), and potassium carbonate (2.9 g, 21.0 mmol) sequentially. After stirring for 20 minutes at room temperature, 1-fluoro-4-nitrobenzene (1 g, 7.09 mmol) was added and the reaction mixture was heated to reflux for 12 hours. After completion of the reaction, it was cooled to room temperature, filtered and the filtrate was concentrated under reduced pressure to obtain the crude product. The crude product was dissolved in water and extracted with ethyl acetate, the organic phase was dried over anhydrous sodium sulfate and the solvent was evaporated under reduced pressure to give 1-(4-nitrophenyl)-piperidin-4-one (0.6 g, 38% yield).

References

[1] Patent: WO2006/123145, 2006, A1. Location in patent: Page/Page column 54-55
[2] Synthesis, 1981, # 8, p. 606 - 608
[3] Synthesis, 1981, # 8, p. 606 - 608
[4] European Journal of Medicinal Chemistry, 2013, vol. 66, p. 32 - 45
[5] Patent: CN106905245, 2017, A

4-Piperidinone, 1-(4-nitrophenyl)- Preparation Products And Raw materials

Raw materials

Preparation Products

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4-Piperidinone, 1-(4-nitrophenyl)- Suppliers

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23499-01-6, 4-Piperidinone, 1-(4-nitrophenyl)-Related Search:

4-Piperidinone, 1-(4-nitrophenyl)-

1-(4-NITROPHENYL)PIPERIDINE-4-ONE

1-(4-nitrophenyl)-4-piperidinone

2(3H)-Benzoxazolone,6-bromo-6-(triphenylmethyl)-

23499-01-6