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1,4-ditosyl-1,4-diazepane

Product Name
1,4-ditosyl-1,4-diazepane
CAS No.
5769-35-7
Chemical Name
1,4-ditosyl-1,4-diazepane
Synonyms
Fasudil Impurity B;1,4-ditosyl-1,4-diazepane;N,N'-di-p-toluenesulfonylhomopiperazine;1H-1,4-Diazepine, hexahydro-1,4-bis[(4-methylphenyl)sulfonyl]-
CBNumber
CB22642817
Molecular Formula
C19H24N2O4S2
Formula Weight
408.53
MOL File
5769-35-7.mol
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1,4-ditosyl-1,4-diazepane Property

Melting point:
149-150 °C
Boiling point:
576.1±60.0 °C(Predicted)
Density 
1.303±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
pka
-5.73±0.20(Predicted)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Ambeed
Product number
A763103
Product name
1,4-Ditosyl-1,4-diazepane
Purity
95%
Packaging
100mg
Price
$22
Updated
2021/12/16
Ambeed
Product number
A763103
Product name
1,4-Ditosyl-1,4-diazepane
Purity
95%
Packaging
250mg
Price
$36
Updated
2021/12/16
Ambeed
Product number
A763103
Product name
1,4-Ditosyl-1,4-diazepane
Purity
95%
Packaging
1g
Price
$106
Updated
2021/12/16
Chemenu
Product number
CM200226
Product name
1,4-Ditosyl-1,4-diazepane
Purity
95%
Packaging
1g
Price
$204
Updated
2021/12/16
Crysdot
Product number
CD12059266
Product name
1,4-Ditosyl-1,4-diazepane
Purity
95+%
Packaging
5g
Price
$366
Updated
2021/12/16
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1,4-ditosyl-1,4-diazepane Chemical Properties,Usage,Production

Uses

1,4-Ditosyl-1,4-diazepane is a derivative Fasudil(F150023). Fasudil is a protein kinase A inhibitor and may be used in medicinal combinations for hepatitis treatment.

Synthesis

107-15-3

109-70-6

98-59-9

5769-35-7

General procedure: 25 kg of ethylenediamine and 80 kg of n-butanol were added to a 500 L enameled reaction tank and stirred at 25°C. The reaction system was then purified by adding 180 kg of toluene sulfonyl chloride and 90 kg of 50% sodium hydroxide solution. Subsequently, 180 kg of p-toluenesulfonyl chloride and 90 kg of 50% sodium hydroxide solution were added to the reaction system with continuous stirring for 20 minutes. The reaction mixture was heated to reflux and then 70 kg of 1-bromo-3-chloropropane and 90 kg of 50% sodium hydroxide solution were added slowly, maintaining the pH of the reaction system at 12. The reaction was continued to be heated and refluxed for 2.5 hours. After the reaction was completed, the solid product was obtained by centrifugation, and after drying, 141 kg of N,N'-bis(p-toluenesulfonyl)homopiperazine was obtained, with a yield of 88.1% and a product purity of 99.0%.

References

[1] Patent: CN104744382, 2017, B. Location in patent: Paragraph 0029; 0032; 0037; 0040; 0042; 0047; 0052

1,4-ditosyl-1,4-diazepane Preparation Products And Raw materials

Raw materials

Preparation Products

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1,4-ditosyl-1,4-diazepane Suppliers

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5769-35-7, 1,4-ditosyl-1,4-diazepaneRelated Search:

5-Quinolinesulfonic acid, 2-methyl- 1,3-Dibromopropane 8-Methylquinoline 5-Isoquinolinesulfonic acid 2-Methylnaphthalene Isoquinoline Fasudil N-hydroxy iMpurity Quinoline 1-Chloro-5-isoquinolinesulfonic Acid FASUDIL QUINOLINE-8-SULFONIC ACID 1-(p-Toluenesulfonyl)hoMopiperazine, 95% HYDROXYFASUDIL MONOHYDROCHLORIDE Ethylenediamine 1-Methylnaphthalene quinoline-5-sulphonic acid Fasudil diMer Fasudil Impurity 6

  • 1,4-ditosyl-1,4-diazepane
  • Fasudil Impurity B
  • N,N'-di-p-toluenesulfonylhomopiperazine
  • 1H-1,4-Diazepine, hexahydro-1,4-bis[(4-methylphenyl)sulfonyl]-
  • 5769-35-7