tert-butyl 4-(pyriMidin-5-yl)piperazine-1-carboxylate

Product Name: tert-butyl 4-(pyriMidin-5-yl)piperazine-1-carboxylate
CAS No.: 634468-96-5
Chemical Name: tert-butyl 4-(pyriMidin-5-yl)piperazine-1-carboxylate
Synonyms: Nicotinamide Impurity 203;tert-butyl 4-(pyriMidin-5-yl)piperazine-1-carboxylate;1-Piperazinecarboxylic acid, 4-(5-pyrimidinyl)-, 1,1-dimethylethyl ester
CBNumber: CB22645090
Molecular Formula: C13H20N4O2
Formula Weight: 264.32
MOL File: 634468-96-5.mol

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tert-butyl 4-(pyriMidin-5-yl)piperazine-1-carboxylate Property

storage temp.: Sealed in dry,Room Temperature
Appearance: Light brown to brown Solid

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

AK Scientific

Product number: Z4977
Product name: tert-Butyl4-(pyrimidin-5-yl)piperazine-1-carboxylate
Packaging: 5g
Price: $444
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0394198
Product name: TERT-BUTYL-4-(PYRIMIDIN-5-YL)PIPERAZINE-1-CARBOXYLATE
Purity: 95.00%
Packaging: 5MG
Price: $505.71
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB143442
Product name: tert-Butyl 4-(pyrimidin-5-yl)piperazine-1-carboxylate
Packaging: 5G
Price: $656.25
Updated: 2021/12/16

Alichem

Product number: 634468965
Product name: tert-Butyl4-(pyrimidin-5-yl)piperazine-1-carboxylate
Packaging: 25g
Price: $1083.6
Updated: 2021/12/16

Ambeed

Product number: A225813
Product name: tert-Butyl4-(pyrimidin-5-yl)piperazine-1-carboxylate
Purity: 98%
Packaging: 250mg
Price: $16
Updated: 2021/12/16

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tert-butyl 4-(pyriMidin-5-yl)piperazine-1-carboxylate Chemical Properties,Usage,Production

Synthesis

4595-59-9

57260-71-6

634468-96-5

(1) Preparation of tert-butyl 4-(pyrimidin-5-yl)piperazine-1-carboxylate: a 100 mL aubergine flask was charged with 5-bromopyrimidine (3.16 g, 20 mmol), N-BOC-piperazine (3.72 g, 20 mmol), 2,2'-bis(diphenylphosphino)-1,1'-binaphthyl (BINAP, 2.49 g, 4 mmol), cesium carbonate ( 13.0 g, 40 mmol) and tris(dibenzylideneacetone)dipalladium (Pd2(dba)3, 1.83 g, 2 mmol). Toluene (80 mL) was then added as solvent. The reaction mixture was heated to 90 °C and stirred for 12 h under the protection of nitrogen atmosphere. Upon completion of the reaction, the mixture was filtrated and the filtrate was concentrated under reduced pressure to remove the solvent. The crude product was purified by silica gel column chromatography with the eluent ratio of dichloromethane:methanol=50:1, and tert-butyl 4-(pyrimidin-5-yl)piperazine-1-carboxylate (3.1 g, 58.7% yield) was finally obtained.

References

[1] Tetrahedron Letters, 2006, vol. 47, # 15, p. 2549 - 2552
[2] Patent: EP3091008, 2016, A1. Location in patent: Paragraph 0380; 0381
[3] Patent: US2005/176722, 2005, A1. Location in patent: Page/Page column 20

tert-butyl 4-(pyriMidin-5-yl)piperazine-1-carboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

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634468-96-5, tert-butyl 4-(pyriMidin-5-yl)piperazine-1-carboxylateRelated Search:

tert-butyl 4-(pyriMidin-5-yl)piperazine-1-carboxylate

1-Piperazinecarboxylic acid, 4-(5-pyrimidinyl)-, 1,1-dimethylethyl ester

Nicotinamide Impurity 203

634468-96-5