ChemicalBook > CAS DataBase List > JW55

JW55

Product Name
JW55
CAS No.
664993-53-7
Chemical Name
JW55
Synonyms
JW55;CS-1095;JW 55; JW-55;JW 55, >=98%;JW 55, 10 mM in DMSO;Tankyrase1/2 Inhibitor IV, JW55;Tankyrase1/2 Inhibitor IV, JW55 - CAS 664993-53-7 - Calbiochem;N-[4-[[4-(4-METHOXYPHENYL)OXAN-4-YL]METHYLCARBAMOYL]PHENYL]FURAN-2-CARBOXAMIDE;N-(4-((4-(4-Methoxyphenyl)tetrahydro-2H-pyran-4-yl)MethylcarbaMoyl)phenyl)furan-2-carboxaMide;N-(4-(((4-(4-Methoxyphenyl)tetrahydro-2H-pyran-4-yl)methyl)carbamoyl)phenyl)furan-2-carboxamid
CBNumber
CB22645126
Molecular Formula
C25H26N2O5
Formula Weight
434.48
MOL File
664993-53-7.mol
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JW55 Property

Boiling point:
572.6±50.0 °C(Predicted)
Density 
1.235±0.06 g/cm3(Predicted)
storage temp. 
Inert atmosphere,2-8°C
solubility 
DMSO: soluble15mg/mL, clear
pka
12.41±0.70(Predicted)
form 
powder
color 
white to beige
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML0630
Product name
JW55
Purity
≥98% (HPLC)
Packaging
5mg
Price
$119
Updated
2024/03/01
Sigma-Aldrich
Product number
575547
Product name
Tankyrase1/2 Inhibitor IV, JW55
Packaging
25mg
Price
$245
Updated
2024/03/01
Cayman Chemical
Product number
16260
Product name
JW 55
Purity
≥98%
Packaging
5mg
Price
$68
Updated
2024/03/01
Cayman Chemical
Product number
16260
Product name
JW 55
Purity
≥98%
Packaging
10mg
Price
$121
Updated
2024/03/01
Sigma-Aldrich
Product number
SML0630
Product name
JW55
Purity
≥98% (HPLC)
Packaging
25mg
Price
$428
Updated
2022/05/15
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JW55 Chemical Properties,Usage,Production

Description

JW 55 is an inhibitor of the PARP domain of tankyrases (TNKS) 1 and 2 (IC50s = 1.9 and 0.83 μM, respectively). By inhibiting TNKS1/2, JW 55 stabilizes Axin2 and increases degradation of β-catenin, inhibiting the β-catenin signaling pathway (IC50 = 470 nM). It has been shown to decrease canonical Wnt signaling in SW480 and HCT15 colon carcinoma cell lines and to reduce proliferation of SW480 cells in vitro.

Uses

JW-55 is an inhibitor of the PARP domain of tankyrase 1 and 2 (TNKS1/2). Activity results in stabilization of Axin2 and increased degradation of β-catenin. JW-55 inhibits the β-catenin signaling pathway. Also shown to decrease canonical Wnt signaling in SW480 and HCT-15 colon carcinoma cell lines. JW-55 reduces cell cycle progression and proliferation in SW480 cells in vitro.

Definition

ChEBI: N-[4-[[[4-(4-methoxyphenyl)-4-oxanyl]methylamino]-oxomethyl]phenyl]-2-furancarboxamide is a member of furans and an aromatic amide.

storage

Store at +4°C

References

[1] waaler j, machon o, tumova l, dinh h, korinek v, wilson sr, paulsen je, pedersen nm, eide tj, machonova o, gradl d, voronkov a, von kries jp, krauss s. a novel tankyrase inhibitor decreases canonical wnt signaling in colon carcinoma cells and reduces tumor growth in conditional apc mutant mice. cancer res. 2012;72(11):2822-32.

JW55 Preparation Products And Raw materials

Raw materials

Preparation Products

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JW55 Suppliers

China 99 India 2 United Kingdom 2 United States 18 Global 121
Jingmo (Xiamen) Biotechnology Co., Ltd
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View Lastest Price from JW55 manufacturers

Career Henan Chemical Co
Product
JW55 664993-53-7
Price
US $1.00/KG
Min. Order
1KG
Purity
98-100%
Supply Ability
1000kg
Release date
2018-08-20

664993-53-7, JW55Related Search:


  • JW55
  • N-(4-((4-(4-Methoxyphenyl)tetrahydro-2H-pyran-4-yl)MethylcarbaMoyl)phenyl)furan-2-carboxaMide
  • N-[4-[[4-(4-METHOXYPHENYL)OXAN-4-YL]METHYLCARBAMOYL]PHENYL]FURAN-2-CARBOXAMIDE
  • N-[4-[[[[Tetrahydro-4-(4-methoxyphenyl)-2H-pyran-4-yl]methyl]amino]carbonyl]phenyl]-2-furancarboxamide
  • JW55 N-[4-[[[[Tetrahydro-4-(4-methoxyphenyl)-2H-pyran-4-yl]methyl]amino]carbonyl]phenyl]-2-furancarboxamide
  • JW 55, >=98%
  • N-(4-(((4-(4-Methoxyphenyl)tetrahydro-2H-pyran-4-yl)methyl)carbamoyl)phenyl)furan-2-carboxamid
  • Tankyrase1/2 Inhibitor IV, JW55
  • Tankyrase1/2 Inhibitor IV, JW55 - CAS 664993-53-7 - Calbiochem
  • JW 55; JW-55
  • CS-1095
  • 2-Furancarboxamide, N-[4-[[[[tetrahydro-4-(4-methoxyphenyl)-2H-pyran-4-yl]methyl]amino]carbonyl]phenyl]-
  • JW 55, 10 mM in DMSO
  • 664993-53-7
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  • Aromatics
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