JW55

ChemicalBook > CAS DataBase List > JW55

Product Name: JW55
CAS No.: 664993-53-7
Chemical Name: JW55
Synonyms: JW55;CS-1095;JW 55; JW-55;JW 55, >=98%;Tankyrase1/2 Inhibitor IV, JW55;Tankyrase1/2 Inhibitor IV, JW55 - CAS 664993-53-7 - Calbiochem;N-[4-[[4-(4-METHOXYPHENYL)OXAN-4-YL]METHYLCARBAMOYL]PHENYL]FURAN-2-CARBOXAMIDE;N-(4-((4-(4-Methoxyphenyl)tetrahydro-2H-pyran-4-yl)MethylcarbaMoyl)phenyl)furan-2-carboxaMide;N-(4-(((4-(4-Methoxyphenyl)tetrahydro-2H-pyran-4-yl)methyl)carbamoyl)phenyl)furan-2-carboxamid;N-[4-[[[[Tetrahydro-4-(4-methoxyphenyl)-2H-pyran-4-yl]methyl]amino]carbonyl]phenyl]-2-furancarboxamide
CBNumber: CB22645126
Molecular Formula: C25H26N2O5
Formula Weight: 434.48
MOL File: 664993-53-7.mol

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JW55 Property

Boiling point:: 572.6±50.0 °C(Predicted)
Density: 1.235±0.06 g/cm3(Predicted)
storage temp.: Inert atmosphere,2-8°C
solubility: DMSO: soluble15mg/mL, clear
pka: 12.41±0.70(Predicted)
form: powder
color: white to beige

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0630
Product name: JW55
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $119
Updated: 2024/03/01

Sigma-Aldrich

Product number: 575547
Product name: Tankyrase1/2 Inhibitor IV, JW55
Packaging: 25mg
Price: $245
Updated: 2024/03/01

Cayman Chemical

Product number: 16260
Product name: JW 55
Purity: ≥98%
Packaging: 5mg
Price: $68
Updated: 2024/03/01

Cayman Chemical

Product number: 16260
Product name: JW 55
Purity: ≥98%
Packaging: 10mg
Price: $121
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML0630
Product name: JW55
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $428
Updated: 2022/05/15

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JW55 Chemical Properties,Usage,Production

Description

JW 55 is an inhibitor of the PARP domain of tankyrases (TNKS) 1 and 2 (IC₅₀s = 1.9 and 0.83 μM, respectively). By inhibiting TNKS1/2, JW 55 stabilizes Axin2 and increases degradation of β-catenin, inhibiting the β-catenin signaling pathway (IC₅₀ = 470 nM). It has been shown to decrease canonical Wnt signaling in SW480 and HCT15 colon carcinoma cell lines and to reduce proliferation of SW480 cells in vitro.

Uses

JW-55 is an inhibitor of the PARP domain of tankyrase 1 and 2 (TNKS1/2). Activity results in stabilization of Axin2 and increased degradation of β-catenin. JW-55 inhibits the β-catenin signaling pathway. Also shown to decrease canonical Wnt signaling in SW480 and HCT-15 colon carcinoma cell lines. JW-55 reduces cell cycle progression and proliferation in SW480 cells in vitro.

Definition

ChEBI: N-[4-[[[4-(4-methoxyphenyl)-4-oxanyl]methylamino]-oxomethyl]phenyl]-2-furancarboxamide is a member of furans and an aromatic amide.

storage

Store at +4°C

References

[1] waaler j, machon o, tumova l, dinh h, korinek v, wilson sr, paulsen je, pedersen nm, eide tj, machonova o, gradl d, voronkov a, von kries jp, krauss s. a novel tankyrase inhibitor decreases canonical wnt signaling in colon carcinoma cells and reduces tumor growth in conditional apc mutant mice. cancer res. 2012;72(11):2822-32.

JW55 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from JW55 manufacturers

Career Henan Chemical Co

Product: JW55 664993-53-7
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98-100%
Supply Ability: 1000kg
Release date: 2018-08-20

664993-53-7, JW55Related Search:

JW55

N-(4-((4-(4-Methoxyphenyl)tetrahydro-2H-pyran-4-yl)MethylcarbaMoyl)phenyl)furan-2-carboxaMide

N-[4-[[4-(4-METHOXYPHENYL)OXAN-4-YL]METHYLCARBAMOYL]PHENYL]FURAN-2-CARBOXAMIDE

N-[4-[[[[Tetrahydro-4-(4-methoxyphenyl)-2H-pyran-4-yl]methyl]amino]carbonyl]phenyl]-2-furancarboxamide

JW55 N-[4-[[[[Tetrahydro-4-(4-methoxyphenyl)-2H-pyran-4-yl]methyl]amino]carbonyl]phenyl]-2-furancarboxamide

JW 55, >=98%

N-(4-(((4-(4-Methoxyphenyl)tetrahydro-2H-pyran-4-yl)methyl)carbamoyl)phenyl)furan-2-carboxamid

Tankyrase1/2 Inhibitor IV, JW55

Tankyrase1/2 Inhibitor IV, JW55 - CAS 664993-53-7 - Calbiochem

JW 55; JW-55

CS-1095

2-Furancarboxamide, N-[4-[[[[tetrahydro-4-(4-methoxyphenyl)-2H-pyran-4-yl]methyl]amino]carbonyl]phenyl]-

664993-53-7

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