NG-25

ChemicalBook > CAS DataBase List > NG-25

Product Name: NG-25
CAS No.: 1315355-93-1
Chemical Name: NG-25
Synonyms: NG25;3-((1H-Pyrrolo[2,3-b]pyridin-4-yl)oxy)-N-(4-((4-ethylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-4-methylbenzamide;NG-25;NG 25; NG-25;HG-7-92-01 (NG 25);NG25, 10 mM in DMSO;NG-25 ISO 9001：2015 REACH;NG25,MAP kinase kinase kinase, MEKK, MAPKKK,NG 25,NG-25,MAP4K,inhibit,Inhibitor,MAP3K,MAPK Kinase Kinase Kinase;N-[4-[(4-ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]-4-methyl-3-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)benzamide;N-[4-[(4-Ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-4-methyl-3-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)benzamide
CBNumber: CB22645146
Molecular Formula: C29H30F3N5O2
Formula Weight: 537.58
MOL File: 1315355-93-1.mol

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NG-25 Property

Density: 1.313±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: Soluble in DMSO
form: powder
pka: 12.91±0.70(Predicted)
color: white to beige
Water Solubility: H2O: 5mg/mL, clear

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Safety

RIDADR: UN 2811 6.1 / PGIII

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H413May cause long lasting harmful effects to aquatic life

Precautionary statements

P273Avoid release to the environment.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1332
Product name: NG25 trihydrochloride
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: $169
Updated: 2023/06/20

Sigma-Aldrich

Product number: SML1332
Product name: NG25 trihydrochloride
Purity: ≥98% (HPLC)
Packaging: 25MG
Price: $676
Updated: 2023/06/20

Tocris

Product number: 5429
Product name: NG25
Purity: ≥98%(HPLC)
Packaging: 5
Price: $325
Updated: 2021/12/16

TRC

Product number: N393510
Product name: NG25
Packaging: 1mg
Price: $85
Updated: 2021/12/16

ChemScene

Product number: CS-0875
Product name: NG25
Purity: 99.35%
Packaging: 1mg
Price: $96
Updated: 2021/12/16

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NG-25 Chemical Properties,Usage,Production

Uses

NG 25 inhibits TGF-beta-activated kinase 1 (TAK1). It also inhibits LYN, mitogen-activated protein kinase (MAP4K2) and Abl kinase activity.

Biochem/physiol Actions

NG25 is potent multiple kinase inhibitor belonging to type II kinase inhibitors class that binds to kinase ATP binding pocket at not ready to catalyze conformation. NG25 is used as a potent dual inhibitor of TAK1 (TGFβ-Activated Kinase 1, MAP3K7) and MAP4K2 (Mitogen-Activated Protein Kinase Kinase Kinase Kinase 2; GCK) kinases. NG25 inhibits the activation of IKKa/IKKb and prevents the secretion of type 1 IFNs by TLR2 and TLR9 agonist.

storage

Store at -20°C

NG-25 Preparation Products And Raw materials

Raw materials

Preparation Products

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NG-25 Suppliers

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1315355-93-1, NG-25Related Search:

Hydroxyethyl piperazine N-Ethylacetamide 2-Aminoethyl(ethyl)amine N-Ethyl-3-methylaniline N-ethyl-pyrrolidone N-(2-Hydroxyethyl)-2-pyrrolidone

3-((1H-Pyrrolo[2,3-b]pyridin-4-yl)oxy)-N-(4-((4-ethylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-4-methylbenzamide

HG-7-92-01 (NG 25)

N-[4-[(4-Ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-4-methyl-3-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)benzamide

3-((1H-pyrrolo[2,3-b]pyridin-4-yl)oxy)-N-(4-((4-ethylpiperazin-1-yl)methyl)-3v-(trifluoromethyl)phenyl)-4-methylbenzamide

N-[4-[(4-ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]-4-methyl-3-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)benzamide

NG25

NG-25

NG 25; NG-25

Benzamide, N-[4-[(4-ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-4-methyl-3-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)-

NG-25 ISO 9001：2015 REACH

NG25,MAP kinase kinase kinase, MEKK, MAPKKK,NG 25,NG-25,MAP4K,inhibit,Inhibitor,MAP3K,MAPK Kinase Kinase Kinase

NG25, 10 mM in DMSO

1315355-93-1

C29H30F3N5O2

Smad

TGF-beta

TGF-beta/Smad