2,2-Difluoro-3-[(2-Methyl-1-oxo-2-propen-1-yl)oxy]pentanoic acid 1,1-diMethylethyl ester
- Product Name
- 2,2-Difluoro-3-[(2-Methyl-1-oxo-2-propen-1-yl)oxy]pentanoic acid 1,1-diMethylethyl ester
- CAS No.
- 1092693-73-6
- Chemical Name
- 2,2-Difluoro-3-[(2-Methyl-1-oxo-2-propen-1-yl)oxy]pentanoic acid 1,1-diMethylethyl ester
- Synonyms
- tert-Butyl 2,2-difluoro-3-(Methacryloyloxy)pentanoate;2,2-Difluoro-3-[(2-Methyl1-0x0-2-propen-1-yl)oxy]pentanoic acid 1,1-diMethylethyl ester;2,2-Difluoro-3-[(2-Methyl-1-oxo-2-propen-1-yl)oxy]pentanoic acid 1,1-diMethylethyl ester;Pentanoic acid, 2,2-difluoro-3-[(2-methyl-1-oxo-2-propen-1-yl)oxy]-, 1,1-dimethylethyl ester
- CBNumber
- CB22648228
- Molecular Formula
- C13H20F2O4
- Formula Weight
- 278.29
- MOL File
- 1092693-73-6.mol
2,2-Difluoro-3-[(2-Methyl-1-oxo-2-propen-1-yl)oxy]pentanoic acid 1,1-diMethylethyl ester Property
- Density
- 1.085
- storage temp.
- 2-8°C
- Appearance
- Colorless to light yellow Liquid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 6688DP
- Product name
- Tert-Butyl2,2-difluoro-3-(methacryloyloxy)pentanoate
- Packaging
- 25g
- Price
- $205
- Updated
- 2021/12/16
- Product number
- HCH0369845
- Product name
- TERT-BUTYL-2,2-DIFLUORO-3-(METHACRYLOYLOXY)PENTANOATE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $497.23
- Updated
- 2021/12/16
- Product number
- CM247683
- Product name
- tert-Butyl2,2-difluoro-3-(methacryloyloxy)pentanoate
- Purity
- 95%+
- Packaging
- 25g
- Price
- $318
- Updated
- 2021/12/16
- Product number
- CD13027099
- Product name
- tert-Butyl2,2-difluoro-3-(methacryloyloxy)pentanoate
- Purity
- 98%
- Packaging
- 25g
- Price
- $337
- Updated
- 2021/12/16
- Product number
- A103735
- Product name
- tert-Butyl2,2-difluoro-3-(methacryloyloxy)pentanoate
- Purity
- 98%
- Packaging
- 1g
- Price
- $25
- Updated
- 2021/12/16
2,2-Difluoro-3-[(2-Methyl-1-oxo-2-propen-1-yl)oxy]pentanoic acid 1,1-diMethylethyl ester Chemical Properties,Usage,Production
Synthesis
1092693-72-5
920-46-7
1092693-73-6
Example 6: General procedure for the preparation of tert-butyl 2,2-difluoro-3-[(2-methyl-1-oxo-2-propen-1-yl)oxy]pentanoate (1-(tert-butoxycarbonyl)-1,1-difluoro-2-butylmethacrylate): in a 25 mL reactor, 1.50 g (5.6 mmol) of tert-butyl 2,2-difluoro-3-hydroxypentanoate was added sequentially, 15 mL of chloroform, 10 mg of NONFLEX MBP, 1.17 g (11.2 mmol, 2.0 eq.) of methacryloyl chloride and 0.87 g (8.6 mmol, 1.5 eq.) of triethylamine. The reaction mixture was stirred at 55 °C for 24 hours. After completion of the reaction, 15 mL of water was added and extracted once with chloroform. The organic layers were combined and washed sequentially with saturated sodium bicarbonate solution and deionized water, then dried with anhydrous magnesium sulfate. After filtration, the solvent was removed by distillation under reduced pressure to afford 1.57 g of the target product 1-(tert-butoxycarbonyl)-1,1-difluoro-2-butyl methacrylate in 58% purity and 58% yield. The product was characterized by the following data: 1H NMR (CDCl3) δ 6.15 (s, 1H; methylene), 5.62 (m, 1H; methylene), 5.36 (m, 1H; CH-O), 1.93 (s, 3H; CH3), 1.78 (m, 2H; CH2), 1.46 (s, 3H; CH3), 0.95 (t, J = 7.6 Hz. 3H; CH3); 19F NMR (CDCl3) δ -113.15 (dd, J = 7.3 Hz, 261 Hz, 1F), -120.17 (dd, J = 14.6 Hz, 261 Hz, 1F).
References
[1] Patent: US2008/311507, 2008, A1
[2] Patent: US2011/98500, 2011, A1. Location in patent: Page/Page column 12
2,2-Difluoro-3-[(2-Methyl-1-oxo-2-propen-1-yl)oxy]pentanoic acid 1,1-diMethylethyl ester Preparation Products And Raw materials
Raw materials
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- Product
- 2,2-Difluoro-3-[(2-Methyl-1-oxo-2-propen-1-yl)oxy]pentanoic acid 1,1-diMethylethyl ester 1092693-73-6
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1000kg
- Release date
- 2025-06-07