Ethyl 2-(6-chloropyridin-2-yl)acetate
- Product Name
- Ethyl 2-(6-chloropyridin-2-yl)acetate
- CAS No.
- 174666-22-9
- Chemical Name
- Ethyl 2-(6-chloropyridin-2-yl)acetate
- Synonyms
- Ethyl 2-(6-chloropyridin-2-yl);Ethyl 2-(6-chloropyridin-2-yl)acetate;2-Pyridineacetic acid, 6-chloro-, ethyl ester
- CBNumber
- CB22651499
- Molecular Formula
- C9H10ClNO2
- Formula Weight
- 199.63
- MOL File
- 174666-22-9.mol
Ethyl 2-(6-chloropyridin-2-yl)acetate Property
- Boiling point:
- 268.7±25.0 °C(Predicted)
- Density
- 1.217±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- -0.35±0.10(Predicted)
- Appearance
- White to yellow Solid-Liquid Mixture
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
N-Bromosuccinimide Price
- Product number
- 2110CY
- Product name
- Ethyl2-(6-chloropyridin-2-yl)acetate
- Packaging
- 100mg
- Price
- $143
- Updated
- 2021/12/16
- Product number
- 131613
- Product name
- Ethyl2-(6-chloropyridin-2-yl)acetate
- Purity
- 97%
- Packaging
- 5g
- Price
- $1170
- Updated
- 2021/12/16
- Product number
- 131613
- Product name
- Ethyl2-(6-chloropyridin-2-yl)acetate
- Purity
- 97%
- Packaging
- 10g
- Price
- $1756
- Updated
- 2021/12/16
- Product number
- BB-4110389
- Product name
- ethyl(6-chloro-2-pyridinyl)acetate
- Purity
- 95%
- Packaging
- 250mg
- Price
- $99
- Updated
- 2021/12/16
- Product number
- CD11232536
- Product name
- Ethyl2-(6-chloropyridin-2-yl)acetate
- Purity
- 95+%
- Packaging
- 1g
- Price
- $218
- Updated
- 2021/12/16
Ethyl 2-(6-chloropyridin-2-yl)acetate Chemical Properties,Usage,Production
Synthesis
18368-63-3
105-58-8
174666-22-9
The general procedure for the synthesis of ethyl 2-(6-chloropyridin-2-yl)acetate from 2-chloro-6-methylpyridine and diethyl carbonate was as follows: referring to the method of Example 6, n-butyllithium (23% hexane solution, 13.2 mL, 47.3 mmol) was added slowly and dropwise to a cold solution of 2-chloro-6-methylpyridine (5.0 g, 39.4 mmol) in tetrahydrofuran (30 mL) ( -70°C) and stirred at -70°C for 30 min. Subsequently, diethyl carbonate (5.75 mL, 47.3 mmol) was slowly added and stirring was continued for 30 minutes at -70°C. The reaction mixture was then warmed to room temperature and stirred for an additional 1 hour. Upon completion of the reaction, the reaction mixture was quenched with aqueous ammonium chloride and extracted with ethyl acetate. The organic layer was washed sequentially with water and brine, dried over anhydrous sodium sulfate, filtered and concentrated to give the crude product. The crude product was purified by column chromatography on silica gel (100-200 mesh), using a petroleum ether solution of 9% ethyl acetate as eluent, to finally obtain ethyl 2-(6-chloropyridin-2-yl)acetate (2.21 g, 28% yield) as an oil.
References
[1] Patent: WO2008/62182, 2008, A1. Location in patent: Page/Page column 111
Ethyl 2-(6-chloropyridin-2-yl)acetate Preparation Products And Raw materials
Raw materials
Preparation Products
Ethyl 2-(6-chloropyridin-2-yl)acetate Suppliers
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View Lastest Price from Ethyl 2-(6-chloropyridin-2-yl)acetate manufacturers
- Product
- Ethyl 2-(6-chloropyridin-2-yl)acetate 174666-22-9
- Price
- US $1.10-9.90/kg
- Min. Order
- 1kg
- Purity
- 99%min
- Supply Ability
- 100kg
- Release date
- 2025-08-14