6-broMo-3-(trifluoroMethyl)-1H-indazole
- Product Name
- 6-broMo-3-(trifluoroMethyl)-1H-indazole
- CAS No.
- 1374258-63-5
- Chemical Name
- 6-broMo-3-(trifluoroMethyl)-1H-indazole
- Synonyms
- 6-bromo-3-(trifluoromethyl)-2H-indazole;6-broMo-3-(trifluoroMethyl)-1H-indazole;1H-Indazole, 6-bromo-3-(trifluoromethyl)-
- CBNumber
- CB22655604
- Molecular Formula
- C8H4BrF3N2
- Formula Weight
- 265.03
- MOL File
- 1374258-63-5.mol
6-broMo-3-(trifluoroMethyl)-1H-indazole Property
- Boiling point:
- 328.2±37.0 °C(Predicted)
- Density
- 1.830±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- 10.38±0.40(Predicted)
- Appearance
- White to light yellow Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 6582AA
- Product name
- 6-Bromo-3-(trifluoromethyl)-1H-indazole
- Packaging
- 100mg
- Price
- $184
- Updated
- 2021/12/16
- Product number
- HCH0367766
- Product name
- 6-BROMO-3-(TRIFLUOROMETHYL)-1H-INDAZOLE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $499.35
- Updated
- 2021/12/16
- Product number
- A171084
- Product name
- 6-Bromo-3-(trifluoromethyl)-1H-indazole
- Purity
- 95%
- Packaging
- 5g
- Price
- $1294
- Updated
- 2021/12/16
- Product number
- CM150339
- Product name
- 6-bromo-3-(trifluoromethyl)-1H-indazole
- Purity
- 95%
- Packaging
- 5g
- Price
- $1477
- Updated
- 2021/12/16
- Product number
- CD11269977
- Product name
- 6-Bromo-3-(trifluoromethyl)-1H-indazole
- Purity
- 95+%
- Packaging
- 5g
- Price
- $1565
- Updated
- 2021/12/16
6-broMo-3-(trifluoroMethyl)-1H-indazole Chemical Properties,Usage,Production
Synthesis
617706-18-0
1374258-63-5
The general procedure for the synthesis of 6-bromo-3-(trifluoromethyl)-1H-indazole using 1-(4-bromo-2-fluorophenyl)-2,2,2-trifluoroethanone as starting material was as follows: to a solution of 1-(4-bromo-2-fluorophenyl)-2,2,2-trifluoroethanone (1.00 g, 3.69 mmol) in 1-butanol (15 mL) was added hydrazine hydrate (3.5 mL of 45 mmol). The reaction mixture was heated to reflux and kept for 5 hours. Upon completion of the reaction, it was cooled to room temperature and stirring was continued overnight. Subsequently, the reaction mixture was diluted with distilled water (50 mL) and extracted with ethyl acetate (3 x 50 mL). The organic phases were combined, washed with saturated saline, dried over anhydrous magnesium sulfate, filtered and concentrated under reduced pressure. The crude product was purified by fast column chromatography (eluent: 0-50% ethyl acetate/heptane gradient elution) to afford the target compound 6-bromo-3-(trifluoromethyl)-1H-indazole (310 mg, 32% yield) as an off-white solid.1H NMR (400 MHz, CDCl3, δ): 7.42 (dd, J = 8.58,1.56 Hz, 1H). 7.72 (d, J = 8.58Hz, 1H), 7.75 (dd, J = 1.56,0.78Hz, 1H).
References
[1] Patent: US2012/108619, 2012, A1. Location in patent: Page/Page column 43
[2] Patent: WO2016/8590, 2016, A1. Location in patent: Page/Page column 55
6-broMo-3-(trifluoroMethyl)-1H-indazole Preparation Products And Raw materials
Raw materials
Preparation Products
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