Tert-butyl 2-oxo-1,2,7,8-tetrahydro-1,6-naphthyridine-6(5h)-carboxylate

Product Name: Tert-butyl 2-oxo-1,2,7,8-tetrahydro-1,6-naphthyridine-6(5h)-carboxylate
CAS No.: 1036381-91-5
Chemical Name: Tert-butyl 2-oxo-1,2,7,8-tetrahydro-1,6-naphthyridine-6(5h)-carboxylate
Synonyms: 6-Boc-5,6,7,8-tetrahydro-1,6-naphthyridin-2(1H)-one;tert-butyl 2-oxo-1,2,7,8-tetrahydro-1,6-naphthyridine-6(5H)-...;tert-butyl 2-hydroxy-7,8-dihydro-1,6-naphthyridine-6(5H)-carboxylate;Tert-butyl 2-oxo-1,2,7,8-tetrahydro-1,6-naphthyridine-6(5h)-carboxylate;1,6-Naphthyridine-6(2H)-carboxylic acid, 1,5,7,8-tetrahydro-2-oxo-, 1,1-dimethylethyl ester
CBNumber: CB22657042
Molecular Formula: C13H18N2O3
Formula Weight: 250.29
MOL File: 1036381-91-5.mol

More

Less

Tert-butyl 2-oxo-1,2,7,8-tetrahydro-1,6-naphthyridine-6(5h)-carboxylate Property

Boiling point:: 470.9±45.0 °C(Predicted)
Density: 1.20±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
pka: 12.39±0.20(Predicted)
Appearance: White to off-white Solid

More

Less

Hazard and Precautionary Statements (GHS)

More

Less

N-Bromosuccinimide Price

Ambeed

Product number: A660000
Product name: tert-Butyl2-oxo-1,2,7,8-tetrahydro-1,6-naphthyridine-6(5H)-carboxylate
Purity: 97%
Packaging: 100mg
Price: $198
Updated: 2021/12/16

Ambeed

Product number: A660000
Product name: tert-Butyl2-oxo-1,2,7,8-tetrahydro-1,6-naphthyridine-6(5H)-carboxylate
Purity: 97%
Packaging: 250mg
Price: $307
Updated: 2021/12/16

Alichem

Product number: 1036381915
Product name: tert-Butyl2-oxo-1,2,7,8-tetrahydro-1,6-naphthyridine-6(5H)-carboxylate
Packaging: 1g
Price: $657.14
Updated: 2021/12/16

Crysdot

Product number: CD11361947
Product name: tert-Butyl2-oxo-1,2,7,8-tetrahydro-1,6-naphthyridine-6(5H)-carboxylate
Purity: 97%
Packaging: 1g
Price: $663
Updated: 2021/12/16

Ambeed

Product number: A660000
Product name: tert-Butyl2-oxo-1,2,7,8-tetrahydro-1,6-naphthyridine-6(5H)-carboxylate
Purity: 97%
Packaging: 1g
Price: $731
Updated: 2021/12/16

More

Less

Tert-butyl 2-oxo-1,2,7,8-tetrahydro-1,6-naphthyridine-6(5h)-carboxylate Chemical Properties,Usage,Production

Synthesis

7341-96-0

79099-07-3

1036381-91-5

To a stirred solution of N-Boc-4-piperidone (35.6 g, 178.89 mmol) in chloroform (260 mL) was slowly added pyrrolidine (19 mL, 223.61 mmol) dropwise over a period of 1 hour at room temperature. The reaction mixture was continued to be stirred at room temperature for 1 hour before propargylamide (16 g, 223.61 mmol) was added. Subsequently, the reaction mixture was subjected to reflux in a Dean-Stark device for 16 hours. After completion of the reaction, the mixture was cooled and filtered. The filtrate was ground with toluene and filtered again. The filtrate was concentrated under reduced pressure to give a red to brown viscous liquid. The crude product was purified by fast column chromatography (silica gel, eluent 98:2 chloroform/methanol) to yield tert-butyl 2-oxo-1,2,7,8-tetrahydro-1,6-naphthyridine-6(5H)-carboxylate (4.01 g, 51.8% yield) as a brown oil.

References

[1] Patent: WO2009/121812, 2009, A1. Location in patent: Page/Page column 75-76

Tert-butyl 2-oxo-1,2,7,8-tetrahydro-1,6-naphthyridine-6(5h)-carboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

Tert-butyl 2-oxo-1,2,7,8-tetrahydro-1,6-naphthyridine-6(5h)-carboxylate Suppliers

China 33 United States 1 Global 34

Shanghai Chainpharm Bio-medical Technology Co., Ltd.

Tel: +86-021-61727342 13611721451
Fax: 021-61294107
Email: sales@chainpharm.com
Country: China
ProdList: 987
Advantage: 58

Shanghai Synteam Biochem CO.,ltd

Tel: +86-021-58380978 13482386415
Fax: 021-58380978
Email: info@systeambc.com
Country: China
ProdList: 896
Advantage: 50

Cool Pharm, Ltd

Tel: 021-60455363 18019463053
Fax: 50966098
Email: sales@coolpharm.com
Country: China
ProdList: 5397
Advantage: 58

ShangHai Wisacheam Pharmaceutical Co., Ltd.

Tel: 13817485796
Fax: QQ:895624079
Email: tim@wisacheampharm.com
Country: China
ProdList: 3658
Advantage: 58

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 86249
Advantage: 60

Shanghai Changyan Chem & Tech Co., Ltd.

Tel: 18930833303 18930833303
Fax: +86 (21) 2024-2659
Email: sales@changyanchem.cn
Country: China
ProdList: 5001
Advantage: 55

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Aikon International Limited

Tel: 025-66061636 19370895928
Fax: (3)02557626880
Email: qqyang@aikonchem.com
Country: China
ProdList: 15813
Advantage: 58

Shanghai Jizhi Biochemical Technology Co. Ltd.

Tel: 021-4009004166/18616739031 18616739031
Email: 3007523370@qq.com
Country: China
ProdList: 52678
Advantage: 58

Suzhou Rovathin Foreign Trade Co.,Ltd

Tel: 0512-65816829 18662214788
Fax: 0512-65816829
Email: info@rovathin.com.cn
Country: China
ProdList: 9967
Advantage: 58

1036381-91-5, Tert-butyl 2-oxo-1,2,7,8-tetrahydro-1,6-naphthyridine-6(5h)-carboxylateRelated Search:

L-Tetrahydrofolic Acid

Tert-butyl 2-oxo-1,2,7,8-tetrahydro-1,6-naphthyridine-6(5h)-carboxylate

tert-butyl 2-oxo-1,2,7,8-tetrahydro-1,6-naphthyridine-6(5H)-...

1,6-Naphthyridine-6(2H)-carboxylic acid, 1,5,7,8-tetrahydro-2-oxo-, 1,1-dimethylethyl ester

6-Boc-5,6,7,8-tetrahydro-1,6-naphthyridin-2(1H)-one

tert-butyl 2-hydroxy-7,8-dihydro-1,6-naphthyridine-6(5H)-carboxylate

1036381-91-5