MK 5172 hydrate
- Product Name
- MK 5172 hydrate
- CAS No.
- 1350462-55-3
- Chemical Name
- MK 5172 hydrate
- Synonyms
- Anapivir;MK5172 hydrate;MK 5172 hydrate;MK-5172 (hydrate);Grazoprevir hydrate;Grazoprevir hydrate (MK-5172 hydrate);GRAZOPREVIR HYDRATE;MK5172 HYDRATE;MK 5172 HYDRATE;(33R,35S,91R,92R,5S)-5-(tert-butyl)-N-((1R,2S)-1-((cyclopropylsulfonyl)carbamoyl)-2-vinylcyclopropyl)-17-methoxy-4,7-dioxo-2,8-dioxa-6-aza-1(2,3)-quinoxalina-3(3,1)-pyrrolidina-9(1,2)-cyclopropanacyclotetradecaphane-35-carboxamide Hydrate;Cyclopropanecarboxamide, N-[[[(1R,2R)-2-[5-(3-hydroxy-6-methoxy-2-quinoxalinyl)pentyl]cyclopropyl]oxy]carbonyl]-3-methyl-L-valyl-(4R)-4-hydroxy-L-prolyl-1-amino-N-(cyclopropylsulfonyl)-2-ethenyl-, cyclic (1→2)-ether, hydrate (1:1), (1R,2S)-
- CBNumber
- CB22666659
- Molecular Formula
- C38H50N6O9S.H2O
- Formula Weight
- 784.91868
- MOL File
- 1350462-55-3.mol
MK 5172 hydrate Property
- storage temp.
- Store at -20°C
- solubility
- DMSO : 50 mg/mL (63.70 mM; Need ultrasonic)H2O : < 0.1 mg/mL (insoluble)
- form
- Powder
- color
- White to off-white
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H373May cause damage to organs through prolonged or repeated exposure
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P314Get medical advice/attention if you feel unwell.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- CS-1376
- Product name
- Grazoprevirhydrate
- Purity
- 99.10%
- Packaging
- 5mg
- Price
- $108
- Updated
- 2021/12/16
- Product number
- CS-1376
- Product name
- Grazoprevirhydrate
- Purity
- 99.10%
- Packaging
- 10mg
- Price
- $168
- Updated
- 2021/12/16
- Product number
- CS-1376
- Product name
- Grazoprevirhydrate
- Purity
- 99.10%
- Packaging
- 50mg
- Price
- $540
- Updated
- 2021/12/16
- Product number
- CS-1376
- Product name
- Grazoprevirhydrate
- Purity
- 99.10%
- Packaging
- 100mg
- Price
- $780
- Updated
- 2021/12/16
- Product number
- CD31003789
- Product name
- MK-5172hydrate
- Purity
- 98+%
- Packaging
- 50mg
- Price
- $1050
- Updated
- 2021/12/16
MK 5172 hydrate Chemical Properties,Usage,Production
Uses
Grazoprevir hydrate (MK-5172 hydrate) is a selective inhibitor of Hepatitis C virus NS3/4a protease with broad activity across genotypes and resistant variants, with Kis of 0.01 nM (gt1b), 0.01 nM (gt1a), 0.08 nM (gt2a), 0.15 nM (gt2b), 0.90 nM (gt3a), respectively[1][2]. Grazoprevir hydrate inhibits SARS-CoV-2 3CLpro activity[3].
in vivo
Grazoprevir (MK-5172) demonstrates efficacy in vivo against chronic-HCV-infected chimpanzees[1]. When dosed to dogs, Grazoprevir (MK-5172) shows low clearance of 5 mL/min/kg and a 3 h half-life after iv dosing and has good plasma exposure (AUC=0.4 μM h) after a 1 mg/kg oral dose. Dog liver biopsy studies showed that the liver concentration of Grazoprevir after the 1 mg/kg oral dose is 1.4 μM at the 24 h time point. Similar to its behavior in rats, Grazoprevir demonstrates effective partitioning into liver tissue and maintains high liver concentration, relative to potency, 24 h after oral dosing in dogs[2].
References
[1] Steven Harper , John A. McCauley , Michael T. Discovery of MK-5172, a Macrocyclic Hepatitis C Virus NS3/4a Protease Inhibitor. ACS Med. Chem. Lett., 2012, 3 (4), pp 332-336
[2] Summa V, Ludmerer SW, McCauley JA, MK-5172, a selective inhibitor of hepatitis C virus NS3/4a protease with broad activity across genotypes and resistant variants. Antimicrob Agents Chemother. 2012 Aug;56(8):4161-7. DOI:10.1128/AAC.00324-12
[3] Qi Sun, et al. Bardoxolone and bardoxolone methyl, two Nrf2 activators in clinical trials, inhibit SARS-CoV-2 replication and its 3C-like protease. Signal Transduct Target Ther. 2021 May 29;6(1):212. DOI:10.1038/s41392-021-00628-x
MK 5172 hydrate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from MK 5172 hydrate manufacturers
- Product
- MK 5172 hydrate 1350462-55-3
- Price
- US $7.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2020-02-13