ChemicalBook > CAS DataBase List > Flumatinib

Flumatinib

Product Name: Flumatinib
CAS No.: 895519-90-1
Chemical Name: Flumatinib
Synonyms: HHGV678;FluMatinib;D3-Flumatinib;FLUMATINIB (HHGV678);Flumatinib, 10 mM in DMSO;HHGV-678,Inhibitor,Flumatinib,Bcr-Abl,inhibit,Platelet-derived growth factor receptor,PDGFR,CD117,SCFR,HHGV 678,c-Kit;4-[(4-methylpiperazin-1-yl)methyl]-N-[6-methyl-5-[(4-pyridin-3-ylpyrimidin-2-yl)amino]pyridin-3-yl]-3-(trifluoromethyl)benzamide;4-[(4-Methyl-1-piperazinyl)methyl]-N-[6-methyl-5-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]-3-pyridinyl]-3-(trifluoromethyl)benzamide;N-(6-Methyl-5-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)pyridin-3-yl)-4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)benzamide;BenzaMide, 4-[(4-Methyl-1-piperazinyl)Methyl]-N-[6-Methyl-5-[[4-(3-pyridinyl)-2-pyriMidinyl]aMino]-3-pyridinyl]-3-(trifluoroMethyl)-
CBNumber: CB22666871
Molecular Formula: C29H29F3N8O
Formula Weight: 562.59
MOL File: 895519-90-1.mol

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Flumatinib Property

Density: 1.340±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO:100.0(Max Conc. mg/mL);177.75(Max Conc. mM)
form: A solid
pka: 11.84±0.70(Predicted)
color: Off-white to yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

ChemScene

Product number: CS-5550
Product name: Flumatinib
Purity: 99.94%
Packaging: 5mg
Price: $84
Updated: 2021/12/16

ChemScene

Product number: CS-5550
Product name: Flumatinib
Purity: 99.94%
Packaging: 10mg
Price: $108
Updated: 2021/12/16

ChemScene

Product number: CS-5550
Product name: Flumatinib
Purity: 99.94%
Packaging: 50mg
Price: $228
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0026221
Product name: FLUMATINIB
Purity: 95.00%
Packaging: 5MG
Price: $504.6
Updated: 2021/12/16

Crysdot

Product number: CD31000382
Product name: Flumatinib
Purity: 98+%
Packaging: 5mg
Price: $49
Updated: 2021/12/16

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Flumatinib Chemical Properties,Usage,Production

Uses

Flumatinib-d3 is deuterium labeled Flumatinib. Flumatinib (HHGV678) is an orally available, selective inhibitor of Bcr-Abl. Flumatinib inhibits c-Abl, PDGFRβ and c-Kit with IC50s of 1.2 nM, 307.6 nM and 665.5 nM, respectively[1].

References

[1] Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. DOI:10.1177/1060028018797110
[2] Luo H, et al. HH-GV-678, a novel selective inhibitor of Bcr-Abl, outperforms imatinib and effectively overrides imatinib resistance. Leukemia. 2010 Oct;24(10):1807-9. DOI:10.1038/leu.2010.169
[3] Zhao J, et al. Flumatinib, a selective inhibitor of BCR-ABL/PDGFR/KIT, effectively overcomes drug resistance of certain KIT mutants. Cancer Sci. 2013 Nov 10. DOI:10.1111/cas.12320
[4] Gong A, et al. Metabolism of flumatinib, a novel antineoplastic tyrosine kinase inhibitor, in chronic myelogenous leukemia patients. Drug Metab Dispos. 2010 Aug;38(8):1328-40. DOI:10.1124/dmd.110.032326

Flumatinib Preparation Products And Raw materials

Raw materials

Preparation Products

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895519-90-1, FlumatinibRelated Search:

BenzaMide, 4-[(4-Methyl-1-piperazinyl)Methyl]-N-[6-Methyl-5-[[4-(3-pyridinyl)-2-pyriMidinyl]aMino]-3-pyridinyl]-3-(trifluoroMethyl)-

4-[(4-Methyl-1-piperazinyl)methyl]-N-[6-methyl-5-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]-3-pyridinyl]-3-(trifluoromethyl)benzamide

FLUMATINIB (HHGV678)

HHGV678

FluMatinib

N-(6-Methyl-5-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)pyridin-3-yl)-4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)benzamide

Flumatinib, 10 mM in DMSO

HHGV-678,Inhibitor,Flumatinib,Bcr-Abl,inhibit,Platelet-derived growth factor receptor,PDGFR,CD117,SCFR,HHGV 678,c-Kit

4-[(4-methylpiperazin-1-yl)methyl]-N-[6-methyl-5-[(4-pyridin-3-ylpyrimidin-2-yl)amino]pyridin-3-yl]-3-(trifluoromethyl)benzamide

N-(6-methyl-5-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)pyridin-3-yl)-4-((4-(methyl-d3)piperazin-1-yl)methyl)-3-(trifluoromethyl)benzamide

D3-Flumatinib

895519-90-1

C29H29F3N8O

API