5-allylpyriMidine-4,6-diol
- Product Name
- 5-allylpyriMidine-4,6-diol
- CAS No.
- 16019-30-0
- Chemical Name
- 5-allylpyriMidine-4,6-diol
- Synonyms
- 5-allylpyriMidine-4,6-diol;5-ALLYL-6-HYDROXYPYRIMIDIN-4(3H)-ONE;5-Allyl-4-hydroxy-1H-pyrimidin-6-one;5-allyl-6-hydroxy-1H-pyrimidin-4-one;4-Hydroxy-5-prop-2-enyl-1H-pyrimidin-6-one;4(3H)-Pyrimidinone, 6-hydroxy-5-(2-propen-1-yl)-
- CBNumber
- CB22667227
- Molecular Formula
- C7H8N2O2
- Formula Weight
- 152.15
- MOL File
- 16019-30-0.mol
5-allylpyriMidine-4,6-diol Property
- Melting point:
- 240 °C
- Density
- 1.27±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- 6.44±0.10(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 3318AH
- Product name
- 5-Allylpyrimidine-4,6-diol
- Packaging
- 250mg
- Price
- $213
- Updated
- 2021/12/16
- Product number
- 3318AH
- Product name
- 5-Allylpyrimidine-4,6-diol
- Packaging
- 1g
- Price
- $415
- Updated
- 2021/12/16
- Product number
- CS-M2479
- Product name
- 5-allylpyrimidine-4,6-diol
- Packaging
- 1g
- Price
- $450
- Updated
- 2021/12/16
- Product number
- 3318AH
- Product name
- 5-Allylpyrimidine-4,6-diol
- Packaging
- 5g
- Price
- $1392
- Updated
- 2021/12/16
- Product number
- A267986
- Product name
- 5-Allylpyrimidine-4,6-diol
- Purity
- 95%
- Packaging
- 5g
- Price
- $523
- Updated
- 2021/12/16
5-allylpyriMidine-4,6-diol Chemical Properties,Usage,Production
Synthesis
2049-80-1
3473-63-0
16019-30-0
Step 2: Ethanol (100 mL) was added to a 500 mL round-bottomed flask under nitrogen protection, followed by the slow addition of sodium metal (4.5 g). After stirring at room temperature until the sodium metal was completely dissolved, the reaction mixture was cooled to 0 °C. Diethyl 2-allylmalonate (12 g) and formamidine acetate (6.24 g) were added sequentially, maintaining a nitrogen atmosphere. The reaction was continued to be stirred at room temperature for 24 hours. Upon completion of the reaction, the reaction was quenched sequentially with acetic acid (20 mL) and water (100 mL). The white precipitate was collected by filtration, washed sequentially with water (4 × 50 mL) and methanol (2 × 50 mL), and dried under vacuum to afford 5-allylpyrimidine-4,6-diol (4 g) as a white solid. NMR hydrogen spectrum (DMSO-d6): δ 2.96 (d, 2H), 4.85 (dd, 1H), 4.91 (dd, 1H), 5.76 (dd, 1H), 7.89 (s, 1H), 11.64 (bs, 2H).
References
[1] Journal of Medicinal Chemistry, 2002, vol. 45, # 17, p. 3639 - 3648
[2] Patent: US2010/144758, 2010, A1. Location in patent: Page/Page column 65-66
[3] Patent: WO2013/138436, 2013, A1. Location in patent: Page/Page column 61
5-allylpyriMidine-4,6-diol Preparation Products And Raw materials
Raw materials
Preparation Products
5-allylpyriMidine-4,6-diol Suppliers
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- Country
- India
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