BenzaMide, 4-(4-ethyl-5-fluoro-2-hydroxyphenoxy)-3-fluoro-
- Product Name
- BenzaMide, 4-(4-ethyl-5-fluoro-2-hydroxyphenoxy)-3-fluoro-
- CAS No.
- 1269055-85-7
- Chemical Name
- BenzaMide, 4-(4-ethyl-5-fluoro-2-hydroxyphenoxy)-3-fluoro-
- Synonyms
- FAB-001;MUT056399;compound I;MUT-056399 (FAB-001);MUT056399, 10 mM in DMSO;4-(4-Ethyl-5-fluoro-2-hydroxyphenoxy)-3-fluorobenzamide;BenzaMide, 4-(4-ethyl-5-fluoro-2-hydroxyphenoxy)-3-fluoro-;Inhibitor,MUT056399,inhibit,Bacterial,Fab 001,MUT-056399,Fab001,MUT 056399
- CBNumber
- CB22667641
- Molecular Formula
- C15H13F2NO3
- Formula Weight
- 293.27
- MOL File
- 1269055-85-7.mol
BenzaMide, 4-(4-ethyl-5-fluoro-2-hydroxyphenoxy)-3-fluoro- Property
- Boiling point:
- 373.8±42.0 °C(Predicted)
- Density
- 1.342±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO : ≥ 31 mg/mL (105.70 mM)
- form
- Solid
- pka
- 8.93±0.48(Predicted)
- color
- White to off-white
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- CS-5339
- Product name
- MUT056399
- Purity
- 99.99%
- Packaging
- 5mg
- Price
- $240
- Updated
- 2021/12/16
- Product number
- CS-5339
- Product name
- MUT056399
- Purity
- 99.99%
- Packaging
- 10mg
- Price
- $400
- Updated
- 2021/12/16
- Product number
- orb611779
- Product name
- MUT-056399
- Packaging
- 10mg
- Price
- $615.4
- Updated
- 2021/12/16
- Product number
- orb611779
- Product name
- MUT-056399
- Packaging
- 50mg
- Price
- $1802
- Updated
- 2021/12/16
- Product number
- orb611779
- Product name
- MUT-056399
- Packaging
- 100mg
- Price
- $2512.6
- Updated
- 2021/12/16
BenzaMide, 4-(4-ethyl-5-fluoro-2-hydroxyphenoxy)-3-fluoro- Chemical Properties,Usage,Production
Uses
MUT056399 (Fab-001) is a highly potent inhibitor of the FabI enzyme of both S. aureus and E. coli with 50% inhibitory concentration IC50s of 12 nM and 58 nM, respectively.
in vivo
MUT056399 (Fab-001), administered subcutaneously, protected mice from a lethal systemic infection induced by MSSA, MRSA, and vancomycin-intermediate S. aureus strains (50% effective doses ranging from 19.3 mg/kg/day to 49.6 mg/kg/day). In the nonneutropenic murine thigh infection model, the same treatment with MUT056399 reduced the bacterial multiplication of MSSA and MRSA in the thighs of immunocompetent mice.
References
[1] Escaich S, et al. The MUT056399 inhibitor of FabI is a new antistaphylococcal compound. Antimicrob Agents Chemother. 2011 Oct;55(10):4692-7. DOI:10.1128/AAC.01248-10
[2] Schiebel J, et al. An ordered water channel in Staphylococcus aureus FabI: unraveling the mechanism of substrate recognitionand reduction. Biochemistry. 2015 Mar 17;54(10):1943-55. DOI:10.1021/bi5014358
BenzaMide, 4-(4-ethyl-5-fluoro-2-hydroxyphenoxy)-3-fluoro- Preparation Products And Raw materials
Raw materials
Preparation Products
BenzaMide, 4-(4-ethyl-5-fluoro-2-hydroxyphenoxy)-3-fluoro- Suppliers
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