GSK J5

Product Name: GSK J5
CAS No.: 1394854-51-3
Chemical Name: GSK J5
Synonyms: GSK-J5;GSK J5;CS-2752;GSK-J5|||GSKJ5;Ethyl N-[2-(3-pyridinyl)-6-(1,2,4,5-tetrahydro-3h-3-benzazepin-3- Yl)-4-pyrimidinyl]-β-alaninate;N-[2-(3-Pyridinyl)-6-(1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-4-pyrimidinyl]-β-alanine ethyl ester;β-Alanine, N-[2-(3-pyridinyl)-6-(1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-4-pyrimidinyl]-, ethyl ester;N-[2-(3-Pyridinyl)-6-(1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-4-pyrimidinyl]-beta-alanine ethyl ester
CBNumber: CB22668284
Molecular Formula: C24H27N5O2
Formula Weight: 417.50348
MOL File: 1394854-51-3.mol

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GSK J5 Property

Boiling point:: 581.2±50.0 °C(Predicted)
Density: 1.216±0.06 g/cm3(Predicted)
storage temp.: Store at RT
solubility: insoluble in H2O; ≥17.3 mg/mL in EtOH with ultrasonic; ≥19.5 mg/mL in DMSO
form: solid
pka: 5.87±0.10(Predicted)
color: Off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: G797560
Product name: GSKJ5
Packaging: 10mg
Price: $205
Updated: 2021/12/16

ApexBio Technology

Product number: A8792
Product name: GSKJ5HCl
Packaging: 5mg
Price: $146
Updated: 2021/12/16

Chemenu

Product number: CM161409
Product name: ethyl3-((2-(pyridin-3-yl)-6-(1,2,4,5-tetrahydro-3H-benzo[d]azepin-3-yl)pyrimidin-4-yl)amino)propanoate
Purity: 95%
Packaging: 10mg
Price: $611
Updated: 2021/12/16

Crysdot

Product number: CD11265845
Product name: GSKJ5
Purity: 95+%
Packaging: 10mg
Price: $654
Updated: 2021/12/16

Crysdot

Product number: CD11265845
Product name: GSKJ5
Purity: 95+%
Packaging: 50mg
Price: $1962
Updated: 2021/12/16

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GSK J5 Chemical Properties,Usage,Production

Uses

GSK J5 is a inactive isomer of GSK J4 (G797555), which is a cell permeable inhibitor of the histone demethylase JMJD3/UTX.

Biological Activity

gsk j5 is an inactive isomer of gsk j4 and a cell-permeable ester derivative of inactive control gsk j2. lysine-specific demethylase 6b (kdm6b), also known as jumonji domain-containing protein d3 (jmjd3), was overexpressed in patients with aml and these patients have a poor prognosis. kdm6b-specific pharmacological inhibitor gsk-j4 had a significant anti-proliferative effect in aml cell lines and freshly isolated bm monocytes (mncs) from aml patients, while h3k27me3 levels were also increasing. gsk-j4 also caused apoptosis and cell cycle arrest in vitro, and reduced tumor burden in vivo in aml xenograft mouse models. it is worth noting that injection of gsk-j4 attenuated disease progression in a human aml xenograft mouse model. treatment with gsk-j4 mainly resulted in downregulation of dna replication and cell cycle-related pathways, and prevents the expression of hox, a key cancer gene. chip-qpcr verified the increased h3k27me3 enrichment in the hox gene transcription initiation site [1].[1]. li y, zhang m, sheng m, zhang p, chen z, xing w, bai j, cheng t, yang fc, zhou y. therapeutic potential of gsk-j4, a histone demethylase kdm6b/jmjd3 inhibitor, for acute myeloid leukemia. j cancer res clin oncol. 2018 jun;144(6):1065-1077. doi: 10.1007/s00432-018-2631-7. epub 2018 mar 28. pubmed pmid: 29594337; pubmed central pmcid: pmc5948279.

GSK J5 Preparation Products And Raw materials

Raw materials

Preparation Products

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GSK J5 Suppliers

China 16 United Kingdom 1 United States 4 Global 21

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1394854-51-3, GSK J5Related Search:

GSK J1 GSK J4 HCl GSK J2

GSK J5

GSK-J5

N-[2-(3-Pyridinyl)-6-(1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-4-pyrimidinyl]-beta-alanine ethyl ester

Ethyl N-[2-(3-pyridinyl)-6-(1,2,4,5-tetrahydro-3h-3-benzazepin-3- Yl)-4-pyrimidinyl]-β-alaninate

N-[2-(3-Pyridinyl)-6-(1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-4-pyrimidinyl]-β-alanine ethyl ester

CS-2752

β-Alanine, N-[2-(3-pyridinyl)-6-(1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-4-pyrimidinyl]-, ethyl ester

GSK-J5|||GSKJ5

1394854-51-3