KX1-004

ChemicalBook > CAS DataBase List > KX1-004

Product Name: KX1-004
CAS No.: 518058-84-9
Chemical Name: KX1-004
Synonyms: KX1-004;CS-1235;KX1-004, >=98%;KX1-004, 518058-84-9;5-fluoro-N-(3-hydroxybenzyl)-1H-indole-2-carboxaMide;5-Fluoro-N-[(3-hydroxyphenyl)methyl]-1H-indole-2-carboxamide;1H-Indole-2-carboxamide, 5-fluoro-N-[(3-hydroxyphenyl)methyl]-;noise,cells,inhibit,Src,hearing,exposure,KX1-004,Inhibitor,loss,KX-1-004,hair;5-Fluoro-N-[(3-hydroxyphenyl)methyl]-1H-indole-2-carboxamide KX1-004;KX1-004 5-Fluoro-N-[(3-hydroxyphenyl)methyl]-1H-indole-2-carboxamide
CBNumber: CB22668299
Molecular Formula: C16H13FN2O2
Formula Weight: 284.29
MOL File: 518058-84-9.mol

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KX1-004 Property

Boiling point:: 628.2±50.0 °C(Predicted)
Density: 1.382±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: insoluble in H2O; ≥10.1 mg/mL in DMSO; ≥3.55 mg/mL in EtOH with gentle warming and ultrasonic
form: solid
pka: 9.77±0.10(Predicted)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 22198
Product name: KX1-004
Purity: ≥98%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 22198
Product name: KX1-004
Purity: ≥98%
Packaging: 5mg
Price: $139
Updated: 2024/03/01

Cayman Chemical

Product number: 22198
Product name: KX1-004
Purity: ≥98%
Packaging: 10mg
Price: $243
Updated: 2024/03/01

Cayman Chemical

Product number: 22198
Product name: KX1-004
Purity: ≥98%
Packaging: 25mg
Price: $533
Updated: 2024/03/01

ChemScene

Product number: CS-3165
Product name: KX1-004
Purity: 99.68%
Packaging: 50mg
Price: $600
Updated: 2021/12/16

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KX1-004 Chemical Properties,Usage,Production

Biological Activity

kx1-004 is a non-atp competitive inhibitor of pp60c-src with ic50 value of 40 μm [1].kx1-004 is a close analog of the indole-based src-ptk inhibitors reported previously. it has a 5-fluoro group and showed potent inhibition activity in isolated src-ptk assay. kx1-004 was found to have protective effect in noise-induced hearing loss. the chinchillas treated with 30 μm kx1-004 were exposed to continuous noise. and the results showed that treated ears exhibited up to 40 db less threshold shift (tts) and up to 25 db less permanent threshold shift (pts) than control ears. kx1-004 treatment also significantly reduced outer hair cell (ohc) loss than control. besides that, kx1-004 was proved to reduce the hearing loss and hair cell loss associated with impulse noise exposure markedly [1, 2].

References

[1] harris k c, hu b, hangauer d, et al. prevention of noise-induced hearing loss with src-ptk inhibitors. hearing research, 2005, 208(1): 14-25.
[2] milkiewicz k l, marsilje t h, woodworth jr r p, et al. the design, synthesis and activity of non-atp competitive inhibitors of pp60 c-src tyrosine kinase. part 2: hydroxyindole derivatives. bioorganic & medicinal chemistry letters, 2000, 10(5): 483-486.

KX1-004 Preparation Products And Raw materials

Raw materials

Preparation Products

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518058-84-9, KX1-004Related Search:

5-Fluoro-N-[(3-hydroxyphenyl)methyl]-1H-indole-2-carboxamide KX1-004

KX1-004 5-Fluoro-N-[(3-hydroxyphenyl)methyl]-1H-indole-2-carboxamide

KX1-004

5-fluoro-N-(3-hydroxybenzyl)-1H-indole-2-carboxaMide

5-Fluoro-N-[(3-hydroxyphenyl)methyl]-1H-indole-2-carboxamide

KX1-004, >=98%

KX1-004, 518058-84-9

CS-1235

1H-Indole-2-carboxamide, 5-fluoro-N-[(3-hydroxyphenyl)methyl]-

noise,cells,inhibit,Src,hearing,exposure,KX1-004,Inhibitor,loss,KX-1-004,hair

518058-84-9

Inhibitors